Abstract:
:Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promoter region, another is located on TRIM39 coding exon. In this study, in order to identify the molecular function of TRIM39, we established gain-of-function of TRIM39 related genes and thus, performed microarray analysis. Our results indicate that TRIM39R, but not TRIM39B, regulates type I interferon response.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kurata R,Tajima A,Yonezawa T,Inoko Hdoi
10.1016/j.bbrc.2013.05.064subject
Has Abstractpub_date
2013-06-21 00:00:00pages
90-5issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(13)00860-7journal_volume
436pub_type
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