Abstract:
:With age human collagen demonstrates, amongst other changes, reductions in solubility, elasticity and permeability. Many of these changes have been attributed to non-enzymic glycosylation (glycation)-a spontaneous addition of sugar molecules to any protein with free amino groups. The resulting formation and accumulation of Advanced Glycation End-products, some of which may be cross-links, has been shown in both long- and short-lived proteins. We have shown that glycation of human corneal and scleral collagen increases with age and that this is accompanied by increases in cross-linking and collagen intermolecular spacing. We have now investigated several compounds that have been used to inhibit glycation, including aspirin, and have shown that all the inhibitors also prevent the increase in intermolecular spacing caused by glycation.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Malik NS,Meek KMdoi
10.1006/bbrc.1994.1282subject
Has Abstractpub_date
1994-03-15 00:00:00pages
683-6issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(84)71282-4journal_volume
199pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2017.12.039
更新日期:2018-01-08 00:00:00
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更新日期:2017-11-25 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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更新日期:2019-08-27 00:00:00
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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更新日期:2020-09-19 00:00:00
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pub_type: 杂志文章
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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更新日期:1999-04-21 00:00:00
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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更新日期:2008-09-26 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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journal_title:Biochemical and biophysical research communications
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更新日期:2018-12-02 00:00:00
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journal_title:Biochemical and biophysical research communications
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更新日期:2020-09-10 00:00:00