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Tumor cell retention of antibody Fab fragments is enhanced by an attached HIV TAT protein-derived peptide.

Abstract：

:Two peptide analogs of the 37-62 sequence region of the HIV TAT protein bind tightly to the surface of A431 breast carcinoma cells. After conjugation to either of two poorly internalized anti-tumor antibody Fab fragments, the analogs enhanced the in vitro cell surface retention and internalization of the Fab fragments to the level of the whole antibodies. This was at the expense of some binding specificity in the case of 1.6 peptides/NRLU-10 Fab, but not in the case of 1.1 peptides/Fab. Enhanced retention may occur by enhanced bivalent binding of the Fab fragments. The internalized fraction of free peptide, but not of the Fab conjugates, is enhanced by chloroquine. The conjugates which were less specific for tumor cell binding may be useful for enhanced retention/internalization of specifically acting agents, for use at specific sites of injection, or against pre-separated target cell populations, while the more specific conjugate may be of interest for further development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Anderson DC,Nichols E,Manger R,Woodle D,Barry M,Fritzberg AR

doi

10.1006/bbrc.1993.1903

subject

Has Abstract

pub_date

1993-07-30 00:00:00

pages

876-84

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71903-0

journal_volume

194

pub_type

杂志文章

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