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Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor.

Abstract：

:A cDNA encoding non-selective type (ETB) of endothelin receptor was isolated from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 442 amino acid residues with a relative Mr of 49,643. The deduced amino acid sequence of human ETB receptor was 88% and 64% identical to those of rat lung ETB receptor and bovine lung ET-1-specific (ETA) receptor, respectively, and contained a relatively long and proline-rich extracellular N-terminal region in addition to a significant similarity with the G protein-coupled receptor super-family with seven transmembrane segments.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nakamuta M,Takayanagi R,Sakai Y,Sakamoto S,Hagiwara H,Mizuno T,Saito Y,Hirose S,Yamamoto M,Nawata H

doi

10.1016/0006-291x(91)91944-8

subject

Has Abstract

pub_date

1991-05-31 00:00:00

pages

34-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91944-8

journal_volume

177

pub_type

杂志文章

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