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Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.

Abstract：

:Opening of high conductance permeability transition pores in mitochondria initiates onset of the mitochondrial permeability transition (MPT). The MPT is a causative event, leading to necrosis and apoptosis in hepatocytes after oxidative stress, Ca(2+) toxicity, and ischemia/reperfusion. CsA blocks opening of permeability transition pores and protects cell death after these stresses. In contrast to necrotic cell death which is a consequence of ATP depletion, ATP is required for the development of apoptosis. Reperfusion and the return of normal pH after ischemia initiate the MPT, but the balance between ATP depletion after the MPT and ATP generation by glycolysis determines whether the fate of cells will be apoptotic or necrotic death. Thus, the MPT is a common pathway leading to both necrotic and apoptotic cell death after ischemia/reperfusion.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kim JS,He L,Lemasters JJ

doi

10.1016/s0006-291x(03)00618-1

subject

Has Abstract

pub_date

2003-05-09 00:00:00

pages

463-70

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03006181

journal_volume

304

pub_type

杂志文章,评审

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