当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Insight into the structural organization of the omega leader of TMV RNA: the role of various regions of the sequence in the formation of a compact structure of the omega RNA.

Insight into the structural organization of the omega leader of TMV RNA: the role of various regions of the sequence in the formation of a compact structure of the omega RNA.

Abstract：

:The 5'-untranslated sequence of tobacco mosaic virus RNA--the so called omega leader--is a well-known translational enhancer. The structure of the omega RNA has unusual features. Despite the absence of extensive secondary structure of the Watson-Crick type, the omega RNA possesses a stable compact conformation. The central part of the omega sequence contains many CAA repeats and is flanked by U-rich regions. In this work we synthesized the polyribonucleotides containing modified omega sequences, and studied them using analytical ultracentrifugation and thermal melting techniques. It was demonstrated that changes made in both the central and the 3'-proximal part of the sequence led to a strong destabilization of the omega RNA structure. We conclude that the regular (CAA)(n) core region and the 3'-proximal AU-rich region of the omega RNA interact with each other and contribute together to the formation of a stable tertiary structure.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Agalarov SC,Sogorin EA,Shirokikh NE,Spirin AS

doi

10.1016/j.bbrc.2010.11.102

subject

Has Abstract

pub_date

2011-01-07 00:00:00

pages

250-3

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)02177-7

journal_volume

404

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Construction of preferential cDNA microarray specialized for human colorectal carcinoma: molecular sketch of colorectal cancer.

    abstract：:cDNA microarray analyses can be used to identify candidate genes that play important roles in human carcinogenesis. To gain insight into the molecular sketch of colorectal cancer, we have constructed cDNA microarrays specialized for colorectal cancer, which we named "Colonochip" by selecting genes that are expressed i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5277

    authors： Takemasa I,Higuchi H,Yamamoto H,Sekimoto M,Tomita N,Nakamori S,Matoba R,Monden M,Matsubara K

    更新日期：2001-08-03 00:00:00

  • Dissecting phenotypic variation among AIS patients.

    abstract：:We have created genital skin fibroblast cell lines directly from three patients in a Chinese family affected by androgen insensitivity syndrome (AIS). All patients in the family share an identical AR Arg840Cys mutant but show different disease phenotypes. By using the cell lines, we find that the mutation has not infl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.077

    authors： Wang M,Wang J,Zhang Z,Zhao Z,Zhang R,Hu X,Tan T,Luo S,Luo Z

    更新日期：2005-09-23 00:00:00

  • Light-induced conformational changes in the extradiscal regions of bovine rhodopsin.

    abstract：:Light-induced conformational changes occurring at the cytosolic surface of rhodopsin were investigated by performing limited digestions of native and illuminated visual pigment with thermolysin, Arg-C endoproteinase, papain and proteinase K. A higher susceptibility of the extradiscal regions of the bleached pigment to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(85)80016-4

    authors： Pellicone C,Nullans G,Cook NJ,Virmaux N

    更新日期：1985-03-29 00:00:00

  • Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines.

    abstract：:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.114

    authors： Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

    更新日期：2007-01-26 00:00:00

  • Binding of deoxyadenylate and deoxycytidylate antibodies to double-stranded DNA.

    abstract：:Antibodies raised against deoxyadenylate and deoxycytidylate were found to react with double stranded DNA as assessed by highly sensitive avidin-biotin microELISA. The binding was specific as it was completely inhibited by the homologous hapten. The antibodies did not react with tRNA and rRNA. These antibodies were al...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90658-4

    authors： Vaishnav YN,Antony A

    更新日期：1988-07-15 00:00:00

  • Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor.

    abstract：:The Mr approximately equal to 90,000 heat shock protein, hsp90, readily interacts with the glucocorticoid receptor to form the 9 S, non-DNA-binding receptor complex. This receptor is stabilized in cytosolic preparations by sodium molybdate. In analogy, sodium molybdate stabilizes a 9 S form of the dioxin receptor. Pol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80566-7

    authors： Denis M,Cuthill S,Wikström AC,Poellinger L,Gustafsson JA

    更新日期：1988-09-15 00:00:00

  • Human kallikrein 13 involvement in extracellular matrix degradation.

    abstract：:The human kallikrein family is a group of 15 serine protease genes clustered on chromosome 19q13.4 and shares a high degree of homology. These proteolytic enzymes have diverse physiological functions in many different tissues. Growing evidence suggests that many kallikreins are differentially expressed in cancer and m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.206

    authors： Kapadia C,Ghosh MC,Grass L,Diamandis EP

    更新日期：2004-10-22 00:00:00

  • Neural precursor cells differentiated from mouse embryonic stem cells relieve symptomatic motor behavior in a rat model of Parkinson's disease.

    abstract：:Pluripotent embryonic stem (ES) cells are the most versatile cells, with the potential to differentiate into all types of cell lineages including neural precursor cells (NPCs), which can be expanded in large numbers for significant periods of time to provide a reliable cell source for transplantation in neurodegenerat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.210

    authors： Xu H,Fan X,Wu X,Tang J,Yang H

    更新日期：2005-01-07 00:00:00

  • Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein.

    abstract：:SEZ-12 is one of the seizure-related cDNAs which was isolated by differential hybridization from primary cultured neurons from the mouse cerebral cortex with or without pentylenetetrazol (PTZ). SEZ-12 expression is transiently down-regulated in the mouse brain by injection of PTZ. To characterize SEZ-12, isolation of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0712

    authors： Kajiwara K,Nagasawa H,Shimizu-Nishikawa K,Ookura T,Kimura M,Sugaya E

    更新日期：1996-05-06 00:00:00

  • Sulfate transport in brush border membrane vesicles prepared from human placental syncytiotrophoblast.

    abstract：:Isolated brush-border membrane vesicles prepared from human placenta are known to transport amino acids via a Na+-dependent mechanism akin to that found in gut and kidney vesicle preparations. We studied sulfate transport in placental vesicles and failed to identify any Na+-dependent uptake mechanism. Rather, uptake i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90402-9

    authors： Cole DE

    更新日期：1984-08-30 00:00:00

  • Oxygen resistant strain of N2-fixing Escherichia coli.

    abstract：:Oxygen resistant N2-fixing Escherichia coli, which can grow at a high oxygen concentration in a nitrogen-free medium, were produced by several times of cultivation under a condition of 0.03% oxygen. Six isolated resistant strains could grow at an oxygen concentration ten times that of the parent strain. The nif-genes ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91706-x

    authors： Iwahashi H,Someya J

    更新日期：1990-04-16 00:00:00

  • IGF-1 prevents oxidative stress induced-apoptosis in induced pluripotent stem cells which is mediated by microRNA-1.

    abstract：:Oxidative stress contributes to tissue injury and cell death during the development of various diseases. The present study aims at investigating whether oxidative stress triggered by the exposure to hydrogen peroxide (H(2)O(2)) can induce apoptosis of induced pluripotent stem cells (iPS cells) in a mechanism mediated ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.08.139

    authors： Li Y,Shelat H,Geng YJ

    更新日期：2012-10-05 00:00:00

  • MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells.

    abstract：:MicroRNAs are involved in cancer-related processes. The microRNA-21(miR-21) has been identified as the only miRNA over-expressed in a wide variety of cancers, including cervical cancer. However, the function of miR-21 is unknown in cervical carcinomas. In this study, we found that the inhibition of miR-21 in HeLa cerv...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.044

    authors： Yao Q,Xu H,Zhang QQ,Zhou H,Qu LH

    更新日期：2009-10-23 00:00:00

  • Nuclear localization signals in the core protein of hepatitis C virus.

    abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2804

    authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

    更新日期：1994-12-15 00:00:00

  • The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.

    abstract：:The mRNA for the novel aldehyde dehydrogenase 5 (ALDH5) gene was detected in HuH7 hepatoma cells. The cells also expressed cytosolic aldehyde dehydrogenase (ALDH1) mRNA, but no mitochondrial aldehyde dehydrogenase (ALDH2) mRNA. Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point si...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1789

    authors： Stewart MJ,Malek K,Xiao Q,Dipple KM,Crabb DW

    更新日期：1995-06-06 00:00:00

  • Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium.

    abstract：:Chloride channels in the ocular ciliary epithelium are believed to play a key role in aqueous humor formation. We isolated a cDNA clone from a lambda Uni-ZAP cDNA library of human nonpigmented ciliary epithelial (NPE) cells encoding the swelling-induced chloride channel/channel regulator pICln. The human clone contain...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1309

    authors： Anguita J,Chalfant ML,Civan MM,Coca-Prados M

    更新日期：1995-03-08 00:00:00

  • On the physiological role of neurocuprein: aponeurocuprein is an inhibitor of dopamine beta-monooxygenase.

    abstract：:The apoform of neurocuprein, the copper protein from brain and chromaffin granules, was found to be a potent inhibitor of the hydroxylating activity of dopamine beta-monooxygenase, whereas the holoform of neurocuprein has no effect on the activity of the enzyme. The inhibiting capacity of neurocuprein may be due to th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90238-x

    authors： Markossian KA,Paitian NA,Mikaelyan MV,Nalbandyan RM

    更新日期：1986-07-16 00:00:00

  • Induction of IL-12 gene expression in the brain in septic shock.

    abstract：:Mental status changes are usually associated with septic shock. However, the molecular mechanisms underlying physiological changes of the central nervous system (CNS) remain speculative. We have investigated the expression of interleukin (IL)-12, one of the central cytokines in inflammatory and immune responses, in th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1038

    authors： Park JH,Shin SH

    更新日期：1996-07-16 00:00:00

  • Vanadate stimulates Na+/H+ exchange activity in A431 cells.

    abstract：:Recent studies have established that polypeptide growth factors cause an elevation of the cytoplasmic pH (pHi) in cultured mammalian cells by stimulating Na+/H+ exchange. We show that vanadate, previously found to act as a mitogen for a number of cells, reversibly activates Na+/H+ exchange at micromolar concentrations...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91356-1

    authors： Cassel D,Zhuang YX,Glaser L

    更新日期：1984-01-30 00:00:00

  • PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain.

    abstract：:PQBP-1 was identified as a binding protein to the polyglutamine tract present in various transcription-related factors and causative genes for neurodegenerative disorders. This novel gene contains at least two functional domains, WW domain and carboxyl-terminal domain (CTD), strictly conserved beyond species. Although...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2992

    authors： Waragai M,Junn E,Kajikawa M,Takeuchi S,Kanazawa I,Shibata M,Mouradian MM,Okazawa H

    更新日期：2000-07-05 00:00:00

  • Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.

    abstract：:Mutations in the preproinsulin protein that affect processing of preproinsulin to proinsulin or lead to misfolding of proinsulin are associated with diabetes. We examined the subcellular localization and secretion of 13 neonatal diabetes-associated human proinsulin proteins (A24D, G32R, G32S, L35P, C43G, G47V, F48C, G...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.090

    authors： Park SY,Ye H,Steiner DF,Bell GI

    更新日期：2010-01-15 00:00:00

  • Effects of phorone (diisopropylidene acetone), a glutathione (GSH) depletor, on hepatic enzymes involved in drug and heme metabolism in rats: evidence that phorone is a potent inducer of heme oxygenase.

    abstract：:Concomitant with the depletion of glutathione content, phorone (250 mg/kg, ip.) produced a marked increase in heme oxygenase activity, biphasic effect on delta-aminolevulinic acid synthetase activity, and slight decreases in cytochrome P-450 content and aminopyrine demethylase activity in the liver of rats. The increa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91349-0

    authors： Yoshida T,Oguro T,Numazawa S,Kuroiwa Y

    更新日期：1987-05-29 00:00:00

  • ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line.

    abstract：:Endemic Alkanna cappadocica was used to isolate novel antitumor molecules from Turkish landscapes in our previous studies. In this study, deoxyalkannin (ALCAP1), β,β-dimethylacrylalkannin (ALCAP2), acetylalkannin (ALCAP3), and alkannin (ALCAP4) as well as the novel isolated compounds 5-methoxydeoxyalkannin (ALCAP5), 8...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.078

    authors： Bogurcu N,Sevimli-Gur C,Ozmen B,Bedir E,Korkmaz KS

    更新日期：2011-06-17 00:00:00

  • Investigation of antidiabetic potential of Phyllanthus niruri L. using assays for α-glucosidase, muscle glucose transport, liver glucose production, and adipogenesis.

    abstract：:Phyllanthus niruri is used in herbal medicine for treatment of diabetes. The objective of this study was to investigate the antidiabetic potential of P. niruri, using assays for α-glucosidase, muscle glucose transport, liver glucose production and adipogenesis. α-Glucosidase inhibitory activity was performed on aqueou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.09.080

    authors： Najari Beidokhti M,Andersen MV,Eid HM,Sanchez Villavicencio ML,Staerk D,Haddad PS,Jäger AK

    更新日期：2017-11-04 00:00:00

  • Phosphorylation and DNA binding of the octamer binding transcription factor Oct-3.

    abstract：:Phosphorylation influences DNA binding and transactivator capabilities of multiple transcription factors. In this study, we demonstrate that the POU-domain transcription factor, Oct-3, can be phosphorylated in vivo. In addition, we show that in COS-1 cells Oct-3 is phosphorylated exclusively on serine residues. Lastly...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2046

    authors： Rosfjord E,Scholtz B,Lewis R,Rizzino A

    更新日期：1995-07-26 00:00:00

  • Crystal structure of wild-type and mutant human Ap4A hydrolase.

    abstract：:Ap4A hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17), an enzyme involved in a number of biological processes, is characterized as cleaving the polyphosphate chain at the fourth phosphate from the bound adenosine moiety. This paper presents the crystal structure of wild-type and E58A mutant h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.01.095

    authors： Ge H,Chen X,Yang W,Niu L,Teng M

    更新日期：2013-03-01 00:00:00

  • Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5.

    abstract：:Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect. Initially we found that triglyceride turnover was faster in hAPOA5 transgenic mice compared to controls, and this strongly correlated w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.003

    authors： Fruchart-Najib J,Baugé E,Niculescu LS,Pham T,Thomas B,Rommens C,Majd Z,Brewer B,Pennacchio LA,Fruchart JC

    更新日期：2004-06-25 00:00:00

  • Regulation of aryl hydrocarbon receptor-mediated transcription in human retinal pigmented epithelial cells.

    abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with pleiotropic effects in normal physiology or vascular development, xenobiotic metabolism, and cancer. A previous study has reported that BRG1, a component of the SWI/SNF complex, is a coactivator for AHR and is recruited to the promoter...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.03.006

    authors： Jin HL,Jeong KW

    更新日期：2016-04-01 00:00:00

  • RhoE enhances multidrug resistance of gastric cancer cells by suppressing Bax.

    abstract：:We have previously reported that RhoE is overexpressed in the SGC7901/VCR cell line. However, the potential role of RhoE in the development of multidrug resistance of gastric cancer is unknown. In the present study, RhoE enhanced the resistance of SGC7901 cells to several kinds of antitumor drugs. RhoE overexpression ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.044

    authors： Li K,Lu Y,Liang J,Luo G,Ren G,Wang X,Fan D

    更新日期：2009-02-06 00:00:00

  • Transcriptional regulation of mouse MARCKS promoter in immortalized hippocampal cells.

    abstract：:Mouse MARCKS is a prominent myristoylated alanine-rich C kinase substrate implicated in brain development, calcium/calmodulin signaling, and membrane cytoskeletal restructuring, and is developmentally regulated in a cell- and tissue-specific fashion. In this study, transcriptional regulation of mouse MARCKS promoter i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6655

    authors： Wang L,Liu X,Lenox RH

    更新日期：2002-04-12 00:00:00