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Insight into the structural organization of the omega leader of TMV RNA: the role of various regions of the sequence in the formation of a compact structure of the omega RNA.

Abstract：

:The 5'-untranslated sequence of tobacco mosaic virus RNA--the so called omega leader--is a well-known translational enhancer. The structure of the omega RNA has unusual features. Despite the absence of extensive secondary structure of the Watson-Crick type, the omega RNA possesses a stable compact conformation. The central part of the omega sequence contains many CAA repeats and is flanked by U-rich regions. In this work we synthesized the polyribonucleotides containing modified omega sequences, and studied them using analytical ultracentrifugation and thermal melting techniques. It was demonstrated that changes made in both the central and the 3'-proximal part of the sequence led to a strong destabilization of the omega RNA structure. We conclude that the regular (CAA)(n) core region and the 3'-proximal AU-rich region of the omega RNA interact with each other and contribute together to the formation of a stable tertiary structure.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Agalarov SC,Sogorin EA,Shirokikh NE,Spirin AS

doi

10.1016/j.bbrc.2010.11.102

subject

Has Abstract

pub_date

2011-01-07 00:00:00

pages

250-3

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)02177-7

journal_volume

404

pub_type

杂志文章

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