Abstract:
:Mental status changes are usually associated with septic shock. However, the molecular mechanisms underlying physiological changes of the central nervous system (CNS) remain speculative. We have investigated the expression of interleukin (IL)-12, one of the central cytokines in inflammatory and immune responses, in the brain from mice intraperitoneally (i.p.) injected with lipopolysaccharide (LPS). Transcripts of the IL-12 p40 gene are markedly induced in the brain, reaching its maximum level 6 h after LPS injection. Microglia-like cells are the primary producers of the p40 transcripts. In contrast, the IL-12 p35 gene is constitutively expressed in the brain at a very low level.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Park JH,Shin SHdoi
10.1006/bbrc.1996.1038subject
Has Abstractpub_date
1996-07-16 00:00:00pages
391-6issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(96)91038-4journal_volume
224pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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