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Subcellular localization of the Schlafen protein family.

Abstract：

:Although the first members of the Schlafen gene family were first described almost 10 years ago, the precise molecular/biochemical functions of the proteins they encode still remain largely unknown. Roles in cell growth, haematopoietic cell differentiation, and T cell development/maturation have, with some experimental support, been postulated, but none have been conclusively verified. Here, we have determined the subcellular localization of Schlafens 1, 2, 4, 5, 8, and 9, representing all three of the murine subgroups. We show that the proteins from subgroups I and II localize to the cytoplasm, while the longer forms in subgroup III localize exclusively to the nuclear compartment. We also demonstrate upregulation of Schlafen2 upon differentiation of haematopoietic cells and show this endogenous protein localizes to the cytoplasm. Thus, we propose the different subgroups of Schlafen proteins are likely to have functionally distinct roles, reflecting their differing localizations within the cell.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Neumann B,Zhao L,Murphy K,Gonda TJ

doi

10.1016/j.bbrc.2008.03.032

subject

Has Abstract

pub_date

2008-05-23 00:00:00

pages

62-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00474-9

journal_volume

370

pub_type

杂志文章

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