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Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450.

Abstract：

:Oxygen inhibition of CCl4 metabolism by different isoenzymes of cytochrome P-450 was assessed by studying liver microsomes isolated from control rats and rats treated with phenobarbital or isoniazid. Rates of CCl4 metabolism were similar for all microsomes under a nitrogen atmosphere. An air atmosphere inhibited metabolism by microsomes from control rats to 12% of the value under nitrogen and metabolism by microsomes from rats treated with phenobarbital to 5%. It inhibited metabolism by microsomes from rats treated with isoniazid only to 32%. Rats treated with phenobarbital, which increases hepatic cytochrome P-450 content, or isoniazid, which does not increase hepatic cytochrome P-450 content, both metabolized more CCl4 than control rats as indicated by exhalation of greater quantities of CCl4 metabolites and by an increase in CCl4 toxicity. These results indicate that some isoenzymes of cytochrome P-450 are more effective than others in metabolizing CCl4 when oxygen is present.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Burk RF,Hill KE,Lane JM

doi

10.1016/s0006-291x(88)80450-9

subject

Has Abstract

pub_date

1988-05-16 00:00:00

pages

1463-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80450-9

journal_volume

152

pub_type

杂志文章

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