Wheat germ phosphoglycerate mutase: evidence for a metalloenzyme.

abstract：:Cyclin D1 (CCND1) is a key regulatory protein at the G1/S checkpoint of the cell cycle. The purpose of our study was to assess the role of CCND1 genotypes influencing the age of onset of oncogenic virus-associated neoplasia. We conducted a hospital-based case-control study of 581 individuals, including 247 controls an...

journal_title：Biochemical and biophysical research communications

authors： Catarino R,Pereira D,Breda E,Coelho A,Matos A,Lopes C,Medeiros R

更新日期：2008-05-23 00:00:00

abstract：:Drug-induced hepatotoxicity causes significant morbidity and mortality and is a major concern in drug development. This is due, in large part, to insufficient knowledge of the mechanism(s) of drug-induced liver injury. In order to address this problem, we have evaluated the modulation of gene expression within the liv...

journal_title：Biochemical and biophysical research communications

authors： Reilly TP,Bourdi M,Brady JN,Pise-Masison CA,Radonovich MF,George JW,Pohl LR

更新日期：2001-03-23 00:00:00

abstract：:Butyrate, a short-chain fatty acid produced in the colon, as well as its prodrug tributyrin, reduce proliferation and increase differentiation of colon cancer cells. p21(Waf1/Cip1) and p27(Kip1) are negative regulators of cell cycle and are thought to have a key function in the differentiation of various cell lines. W...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Wächtershäuser A,Steinhilber D,Stein J

更新日期：2001-04-27 00:00:00

abstract：:The murine 3T3-L1 preadipocyte cell line is well characterized for its capacity to undergo differentiation into adipocytes under appropriate hormonal stimulation. p107, a member of the retinoblastoma tumor suppressor gene family has been shown to be dramatically upregulated during the early requisite clonal expansion ...

journal_title：Biochemical and biophysical research communications

authors： May JS,Prince AM,Lyle RE,McGehee RE Jr

更新日期：2001-05-18 00:00:00

abstract：:Salmon calcitonin potently competes for amylin binding sites in rat brain and has amylin-like actions upon glucose metabolism in rat muscle. We report here that [125I]-salmon calcitonin binds to rat hindlimb muscle membranes with high affinity (Kd = 0.47 pM). Binding was inhibited by rat amylin (Ki = 2 nM), rat alpha ...

journal_title：Biochemical and biophysical research communications

authors： Kenney MA,Moore CX,Pittner R,Beaumont K

更新日期：1993-11-30 00:00:00

abstract：:(6R)5,6,7,8 tetrahydrobiopterin (6-BH4) is an important cofactor in the regulation of melanogenesis in melanocytes, where it controls: (a) the supply of L-tyrosine from L-phenylalanine via phenylalanine hydroxylase, and (b) regulates directly dopaquinone formation from L-tyrosine via tyrosinase. 6-BH4 undergoes redox-...

journal_title：Biochemical and biophysical research communications

authors： Schallreuter KU,Büttner G,Pittelkow MR,Wood JM,Swanson NN,Körner C

更新日期：1994-10-14 00:00:00

abstract：:v-Src activates gene expression mediated by serum response elements (SREs) and TPA response elements (TREs). v-Src-induced SRE- and TRE-mediated gene expressions are both dependent upon HaRas. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that has been implicated in v-Src-initiated signals. We report...

journal_title：Biochemical and biophysical research communications

authors： Gupta R,Foster DA

更新日期：1994-12-15 00:00:00

abstract：:The effect of thyroid-stimulating hormone receptor (TSHR) on hepatic lipid accumulation in vivo is not fully understood. Further, while TSHR in the thyroid has been studied extensively, whether and how the absence of TSHR in the liver affects systemic energy metabolism has not yet been reported. To examine these effec...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Wu K,Zhang L,Gao L,Chen S

更新日期：2018-02-26 00:00:00

abstract：:Planar cell polarity (PCP) signaling controls polarized behaviors in diverse tissues, including the collective cell movements of gastrulation and the planar polarized beating of motile cilia. A major question in PCP signaling concerns the mechanisms linking this signaling cascade with more general cytoskeletal element...

journal_title：Biochemical and biophysical research communications

authors： Park TJ,Kim SK,Wallingford JB

更新日期：2015-01-09 00:00:00

abstract：:Licorice is a popular medicinal plant, and it has been used to treat various diseases, including liver diseases. Glycycoumarin (GCM) is a major coumarin compound isolated from licorice with favorable bioavailability property. Our previous studies have shown that GCM is capable of inhibiting lipoapoptosis in both cell ...

journal_title：Biochemical and biophysical research communications

authors： Zhang E,Yin S,Zhao C,Fan L,Hu H

更新日期：2020-07-12 00:00:00

abstract：:Cot/Tpl2, a member of MAP kinase kinase kinase (MAPKKK), is indispensable for the ERK activation, as well as the production of TNF-α, IL-1β, IL-23, and PGE(2) in lipopolysaccharide (LPS)-stimulated macrophages. However, the expression and the functional roles of Cot/Tpl2 in mast cells have not been elucidated. The adm...

journal_title：Biochemical and biophysical research communications

authors： Chiba N,Kakimoto K,Masuda A,Matsuguchi T

更新日期：2010-11-05 00:00:00

abstract：:Catalytic activities of cytochrome P450 2B4 lacking NH2-terminal amino acids 2-27 (wt Delta2B4) and that of truncated 2B4 containing a Pro to Ser mutation at position 221 were examined in a system supported by cumene hydroperoxide. Demethylation activities of either truncated 2B4 with N-methylaniline, N,N-dimethylanil...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Pernecky SJ

更新日期：1999-04-29 00:00:00

abstract：:Functional role of CD44, a principal receptor of hyaluronan, and glycated albumin for differentiation of resting human monocytes isolated by counterflow centrifugal elutriation was investigated. Flow cytometric analysis revealed that amadori-modified glycated albumin induced expression of CD44 as well as macrophage sc...

journal_title：Biochemical and biophysical research communications

authors： Kishikawa H,Mine S,Kawahara C,Tabata T,Hirose A,Okada Y,Tanaka Y

更新日期：2006-01-20 00:00:00

abstract：:Filamin increases and tropomyosin decreases the susceptibility of F-actin to form bundles of filaments in the presence of polyethylene glycol 6000. The two proteins, which are located in the leading edge and in the internal part of the cell, respectively, are thus likely to display divergent effects on the microfilame...

journal_title：Biochemical and biophysical research communications

authors： Grazi E,Trombetta G,Guidoboni M

更新日期：1990-03-30 00:00:00

abstract：:The effects of thyroid hormone on cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, apo A-I and farnesyl pyrophosphate synthetase hepatic mRNA levels were investigated in hypophysectomized rats. Of these mRNAs cholesterol 7 alpha hydroxylase responded the most rapidly and required the lowest dose of T3...

journal_title：Biochemical and biophysical research communications

authors： Ness GC,Pendleton LC,Li YC,Chiang JY

更新日期：1990-11-15 00:00:00

abstract：:Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the me...

journal_title：Biochemical and biophysical research communications

authors： Kang B,Kim Y,Park TJ,Kang HY

更新日期：2020-03-19 00:00:00

abstract：:A guinea pig adrenal hydroxysteroid sulfotransferase (gpHST2) has been cloned that is distinct from guinea pig hydroxysteroid sulfotransferase that stereoselectively acts on 3 alpha-hydroxylated neutral steroids (gp3 alpha HST, redesignated gpHST1). The deduced amino acid sequences for gpHST1 and gpHST2 are 86% identi...

journal_title：Biochemical and biophysical research communications

authors： Luu NX,Driscoll WJ,Martin BM,Strott CA

更新日期：1995-12-26 00:00:00

abstract：:The risk of terrorist attacks utilizing either nuclear or radiological weapons has raised concerns about the current lack of effective radioprotectants. Here it is demonstrated that the BH4 peptide domain of the anti-apoptotic protein Bcl-xL can be delivered to cells by covalent attachment to the TAT peptide transduct...

journal_title：Biochemical and biophysical research communications

authors： McConnell KW,Muenzer JT,Chang KC,Davis CG,McDunn JE,Coopersmith CM,Hilliard CA,Hotchkiss RS,Grigsby PW,Hunt CR

更新日期：2007-04-06 00:00:00

abstract：:A mathematical model that includes biochemical interactions among the PTS system, phosphofructokinase (PFK), and pyruvate kinase (PK) is used to evaluate the dynamic behavior of the glycolytic pathway of Escherichia coli under steady-state conditions. The influence of ADP, phosphoenolpyruvate (PEP), and fructose-6-pho...

journal_title：Biochemical and biophysical research communications

authors： Diaz Ricci JC

更新日期：2000-04-29 00:00:00

abstract：:The apicomplexan Toxoplasma gondii, an obligate intracellular parasite, can infect humans and a wide range of vertebrates. Following oral infection, the parasite invades tissues by crossing non-permissive biological barriers such as the placenta or the blood-brain barrier. But the molecular mechanisms underlying migra...

journal_title：Biochemical and biophysical research communications

authors： Buache E,Garnotel R,Aubert D,Gillery P,Villena I

更新日期：2007-07-27 00:00:00

abstract：:Cathepsin E is a major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway. In the present review some of the known features of cathepsin E such as tissue distribution, subcellular localization, enz...

journal_title：Biochemical and biophysical research communications

authors： Zaidi N,Kalbacher H

更新日期：2008-03-14 00:00:00

abstract：:Mutation in DJ-1 gene is the cause of autosomal recessive Parkinson's disease, however, its physiological function remains unclear. The isoelectric point of DJ-1 shows an acidic shift after cells are treated with hydrogen peroxide. This suggests that DJ-1 is modified in response to oxidative stress. Here we report the...

journal_title：Biochemical and biophysical research communications

authors： Kinumi T,Kimata J,Taira T,Ariga H,Niki E

更新日期：2004-05-07 00:00:00

abstract：:Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity. H9c2 cardiomyoblast cells were treated with differe...

journal_title：Biochemical and biophysical research communications

authors： Gyongyosi A,Szoke K,Fenyvesi F,Fejes Z,Debreceni IB,Nagy B Jr,Tosaki A,Lekli I

更新日期：2019-04-16 00:00:00

abstract：:Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

更新日期：2016-09-23 00:00:00

abstract：:We previously reported that fucoidan, a dietary fiber purified from seaweed, inhibited IgE production by B cells in vitro. In this study, we examined the effect of fucoidan on IgE production in vivo. The OVA-induced increase of plasma IgE was significantly suppressed when fucoidan was intraperitoneally, but not orally...

journal_title：Biochemical and biophysical research communications

authors： Yanase Y,Hiragun T,Uchida K,Ishii K,Oomizu S,Suzuki H,Mihara S,Iwamoto K,Matsuo H,Onishi N,Kameyoshi Y,Hide M

更新日期：2009-09-25 00:00:00

abstract：:We linked a 3.3 kb fragment containing the human gamma-globin gene together with a 5.5 kb fragment containing the human beta-globin gene. This construct was introduced into the germ line of mice. Analysis of the resulting transgenic mice showed that expression of the human gamma- and beta-globin genes were regulated a...

journal_title：Biochemical and biophysical research communications

authors： Katsube T,Tojo H,Sakaguchi T,Fukumaki Y

更新日期：1993-07-15 00:00:00

abstract：:Aggregated β-amyloid peptides (Aβ) are neurotoxic and responsible for neuronal death both in vitro and in vivo. From the structural point of view, Aβ self-aggregation involves a conformational change in the peptide. Here, we investigated the relationship between conformational changes and amino acid residues of Aβ(40)...

journal_title：Biochemical and biophysical research communications

authors： Chen YR,Huang HB,Lo CJ,Wang CC,Su CL,Liu HT,Shiao MS,Lin TH,Chen YC

更新日期：2011-02-04 00:00:00

abstract：:The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min (APC(Min/+)) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups (N=10) of six-week-old female C57BL/6J APC(Min/+) and the co...

journal_title：Biochemical and biophysical research communications

authors： Williams JL,Kashfi K,Ouyang N,del Soldato P,Kopelovich L,Rigas B

更新日期：2004-01-16 00:00:00

abstract：:Regulation of gene expression in cells is mediated by protein-protein, DNA-protein and receptor-ligand interactions. PDZ (PSD-95/Discs-large/ZO-1) domains are protein-protein interaction modules. PDZ-containing proteins function in the organization of multi-protein complexes controlling spatial and temporal fidelity o...

journal_title：Biochemical and biophysical research communications

authors： Zencir S,Banerjee M,Dobson MJ,Ayaydin F,Fodor EA,Topcu Z,Mohanty S

更新日期：2013-03-01 00:00:00

abstract：:Hepatocyte growth factor (HGF), originally identified as a potent mitogen for mature parenchymal hepatocytes, is a hepatotrophic factor involved in liver regeneration and is even essential for development of the liver. We report here that human recombinant HGF at a very low concentration and given intraportaly stimula...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi Y,Hamanoue M,Ueno S,Aikou T,Tanabe G,Mitsue S,Matsumoto K,Nakamura T

更新日期：1996-03-07 00:00:00