Abstract:
:Functional role of CD44, a principal receptor of hyaluronan, and glycated albumin for differentiation of resting human monocytes isolated by counterflow centrifugal elutriation was investigated. Flow cytometric analysis revealed that amadori-modified glycated albumin induced expression of CD44 as well as macrophage scavenger receptors (MSRs) such as CD36 and CD68 on resting monocytes. Crosslinking of CD44 on monocytes also induced MSR expression. Furthermore, CD44 crosslinking and/or glycated albumin enhanced the uptake of oxidized-low density lipoprotein in monocytes and foam cell formation. Taken together, engagement of CD44 (e.g., hyaluronan) and glycated albumin induced the differentiation of resting monocytes into foam macrophages through the induction of MSRs, implying that CD44 could be involved in atherosclerotic lesions of those such as diabetic patients.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kishikawa H,Mine S,Kawahara C,Tabata T,Hirose A,Okada Y,Tanaka Ydoi
10.1016/j.bbrc.2005.11.091subject
Has Abstractpub_date
2006-01-20 00:00:00pages
846-51issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(05)02576-3journal_volume
339pub_type
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journal_title:Biochemical and biophysical research communications
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