Relationship between the uptake and cytotoxicity of celiptium in wild type and resistant mutants of the bacterium Streptococcus pneumoniae.

abstract：:Transforming growth factor-beta (TGF-beta) is crucially virulent in the progression of fibrotic disorders. TAK1 (TGF-beta activated kinase 1) is one of the mitogen-activated kinase kinase kinase (MAPKKK) that is involved in TGF-beta signal transduction. To elucidate the importance of TAK1 in TGF-beta-induced fibrotic ...

journal_title：Biochemical and biophysical research communications

authors： Ono K,Ohtomo T,Ninomiya-Tsuji J,Tsuchiya M

更新日期：2003-07-25 00:00:00

abstract：:Reactive oxygen species (ROS) are important factors mediating aging according to the free radical theory of aging. Few studies have systematically measured ROS levels in relationship to aging, partly due to the lack of tools for detection of specific ROS in live animals. By using the H₂O₂-specific fluorescence probe P...

journal_title：Biochemical and biophysical research communications

authors： Fu X,Tang Y,Dickinson BC,Chang CJ,Chang Z

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Numerous previous studies have revealed that many long non-coding RNAs (lncRNAs) are upregulated in gastric cancer (GC) and are associated with tumor onset and progression in GC. ADPGK-AS1, a novel lncRNA, has been discovered as an oncogenic lncRNA in pancreatic cancer while its function in GC remains unclea...

journal_title：Biochemical and biophysical research communications

authors： Huang Z,Yang H

更新日期：2019-05-21 00:00:00

abstract：:The apicomplexan Toxoplasma gondii, an obligate intracellular parasite, can infect humans and a wide range of vertebrates. Following oral infection, the parasite invades tissues by crossing non-permissive biological barriers such as the placenta or the blood-brain barrier. But the molecular mechanisms underlying migra...

journal_title：Biochemical and biophysical research communications

authors： Buache E,Garnotel R,Aubert D,Gillery P,Villena I

更新日期：2007-07-27 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Liver X receptor (LXR) alpha is known to be involved in the control of cholesterol homeostasis. Thus, the purpose of this study was to investigate the effects of 3-methlycholanthrene (MC), one of the PAHs, on LXRalp...

journal_title：Biochemical and biophysical research communications

authors： Iwano S,Nukaya M,Saito T,Asanuma F,Kamataki T

更新日期：2005-09-16 00:00:00

abstract：:Fractionation of rat uterine cells incubated at 22 degrees C with 0.2 nM [3H]-estradiol-17 beta (E2 beta) was performed to analyze the subcellular distribution of internalized hormone. The postnuclear supernatant of homogenates was resolved in Percoll density gradients into six major fractions defined by enzyme marker...

journal_title：Biochemical and biophysical research communications

authors： Pietras RJ,Szego CM

更新日期：1984-08-30 00:00:00

abstract：:A newly identified human peptide, adrenomedullin (AM) increased cAMP levels with dose and time dependencies in a manner similar to that of human calcitonin gene-related peptide (CGRP) in rat vascular smooth muscle cells (VSMC). The EC50 value of human AM is 2 x 10(-8) M which is slightly higher than that of CGRP (8.5 ...

journal_title：Biochemical and biophysical research communications

authors： Ishizaka Y,Ishizaka Y,Tanaka M,Kitamura K,Kangawa K,Minamino N,Matsuo H,Eto T

更新日期：1994-04-15 00:00:00

abstract：:The effects of insulin on the steady-state level of human insulin receptor (hIR) mRNA were examined in the HepG2 human liver cell line using Northern blot analysis of either total cellular or poly(A)+ RNA. In control cells, up to six (4.5, 5.2, 7.4, 8.5, 9.4 and 10.8 kb) hybridizable species of hIR mRNA were identifie...

journal_title：Biochemical and biophysical research communications

authors： Rohilla AM,Anderson C,Wood WM,Berhanu P

更新日期：1991-03-15 00:00:00

abstract：:SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangol...

journal_title：Biochemical and biophysical research communications

authors： Luan J,Lu Y,Jin X,Zhang L

更新日期：2020-05-21 00:00:00

abstract：:Transcription factors belonging to the CCAAT-enhancer binding protein (C/EBP) family have been implicated in the regulation of gene expression during growth, differentiation, apoptosis, and inflammation. Autoregulation is relatively common in the modulation of C/EBP gene expression and, for the human and murine C/EBPa...

journal_title：Biochemical and biophysical research communications

authors： Davies GE,Sabatakos G,Cryer A,Ramji DP

更新日期：2000-05-10 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) produced by hepatocellular carcinoma (HCC) cells are responsible for the growth of HCC cells. Accumulating evidence shows that insulin-like growth factor-binding protein-3 (IGFBP-3) suppresses HCC cell proliferation in both IGF-dependent a...

journal_title：Biochemical and biophysical research communications

authors： Ma Y,Han CC,Li Y,Wang Y,Wei W

更新日期：2016-09-16 00:00:00

abstract：:The oral mucosa is susceptible to tissue injury from many causes, including infection, autoimmune disorders, surgical and accidental trauma, and gingival and periodontal inflammation; however, little is known about the events that influence wound healing in the mouth. Recent studies in non-oral tissues have implicated...

journal_title：Biochemical and biophysical research communications

authors： McGrory K,Flaitz CM,Klein JR

更新日期：2004-11-05 00:00:00

abstract：:In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in the brain reward system. Using a conditional place preference test, the rewarding effect was clearly evoked by scratching under both acute and chronic itch stimuli. The induc...

journal_title：Biochemical and biophysical research communications

authors： Setsu T,Hamada Y,Oikawa D,Mori T,Ishiuji Y,Sato D,Narita M,Miyazaki S,Furuta E,Suda Y,Sakai H,Ochiya T,Tezuka H,Iseki M,Inada E,Yamanaka A,Kuzumaki N,Narita M

更新日期：2021-01-01 00:00:00

abstract：:After proliferative activation of rat liver cells in vivo by a partial hepatectomy a decrease of the calmodulin content in the three plasma membrane domains (blood sinusoidal, canalicular and lateral) was observed. At 24 hours after partial hepatectomy calmodulin was found to be 3 fold lower in the sinusoidal and late...

journal_title：Biochemical and biophysical research communications

authors： Pujades C,Bastos R,Enrich C,Bachs O

更新日期：1990-12-31 00:00:00

abstract：:The inactivation of human factor X by incubation with a reagent known to chemically modify gamma-carboxyglutamic acid to gamma-methylene glutamic acid was studied. Incubation of factor X at pH 5.0 with a preincubated formaldehyde/morpholine mixture (0.9 M/1.0 M) resulted in a progressive decrease in factor X coagulant...

journal_title：Biochemical and biophysical research communications

authors： Sherrill GB,Straight DL,Hiskey RG,Roberts HR,Griffith MJ

更新日期：1984-10-15 00:00:00

abstract：:Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it. We observed that curcumin activated MST1-dependent apoptosis in cultured melanoma cells. MST1 silencing by RNA interference (RNAi) suppressed curcumin-i...

journal_title：Biochemical and biophysical research communications

authors： Yu T,Ji J,Guo YL

更新日期：2013-11-08 00:00:00

abstract：:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common ...

journal_title：Biochemical and biophysical research communications

authors： Vlasuk GP,Miller J,Bencen GH,Lewicki JA

更新日期：1986-04-14 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Wang H,Duan Y,Yang H

更新日期：2020-11-21 00:00:00

abstract：:Actin depolymerization through Rho GTPases or exogenous mechanical tension has been suggested as a key determinant for the formation of astrocyte stellation. Rho GTPases function as switching molecules to converge both extracellular and intracellular signals in regulation of cytoskeletal organization. Their involvemen...

journal_title：Biochemical and biophysical research communications

authors： Chen CJ,Liao SL,Huang YS,Chiang AN

更新日期：2005-01-28 00:00:00

abstract：:1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) increases the binding of transforming growth factor beta1(TGF beta1) via TGF beta receptors to the surface of human osteoblasts. The increase in TGF beta receptors induced by 1alpha,25(OH)2D3 is dependent on increases in TGF beta secretion induced by 1alpha,25(OH)2D3, s...

journal_title：Biochemical and biophysical research communications

authors： Nagel D,Kumar R

更新日期：2002-02-08 00:00:00

abstract：:Transcriptional factors (TFs) are key regulators in orchestrating gene transcription during cancer development. However, their roles in glioma remain elusive. Here, we analyzed the differential expression of TFs and identified ZNF436 is upregulated in glioblastoma and Lower Grade Glioma patients. High expression of ZN...

journal_title：Biochemical and biophysical research communications

authors： Shang Y,Li Y,Zhang Y,Wang J

更新日期：2019-08-06 00:00:00

abstract：:A new cleavage site, which is a post-translational modification, was found between residues His-154 and Ala-155 in alpha A-crystallin from the aged human lens. After trypsin digestion of alpha A-crystallin two peptides that include Asp-151 were obtained and have remarkable differences. That is, the stereo-configuratio...

journal_title：Biochemical and biophysical research communications

authors： Fujii N,Momose Y,Yamasaki M,Yamagaki T,Nakanishi H,Uemura T,Takita M,Ishii N

更新日期：1997-10-29 00:00:00

abstract：:We generated a set of GFP-tagged chimeras between protein kinase D2 (PKD2) and protein kinase D3 (PKD3) to examine in live cells the contribution of their C-terminal region to their intracellular localization. We found that the catalytic domain of PKD2 and PKD3 can localize to the nucleus when expressed without other ...

journal_title：Biochemical and biophysical research communications

authors： Papazyan R,Rozengurt E,Rey O

更新日期：2006-04-14 00:00:00

abstract：:The homeodomain transcription factor Pdx1 is essential for pancreas formation and functions in pancreatic islets cells to regulate genes involved in maintenance of glucose homeostasis. In order to investigate a role for Pdx1 in intestinal cells, we analyzed the functions and networks associated with genes differential...

journal_title：Biochemical and biophysical research communications

authors： Chen C,Leavitt T,Sibley E

更新日期：2012-08-03 00:00:00

abstract：:MicroRNA (miRNA)-mediated gene silencing has recently emerged as a major mechanism of gene expression regulation during development in a variety of species. Little is known, however, about the presence of components of miRNA machinery in mammalian organogenesis. In this study, we report that members of the Argonaute (...

journal_title：Biochemical and biophysical research communications

authors： Lü J,Qian J,Chen F,Tang X,Li C,Cardoso WV

更新日期：2005-08-26 00:00:00

abstract：:We report the usefulness of an impedance-based label-free whole cell assay to identify new ligands for G protein-coupled receptors (GPCRs) involved in microglial cell migration. Authentic GPCR ligands were subjected to the impedance-based cell assay in order to examine the responses of ligands for MG5 mouse microglial...

journal_title：Biochemical and biophysical research communications

authors： Fukano Y,Okino N,Furuya S,Ito M

更新日期：2016-09-16 00:00:00

abstract：:We have isolated, in guinea-pig endometrial cells, an estrogen-induced 1.8 kb RNA called gec1. Screening of a guinea-pig genomic library led to identification of gec1 gene consisting of 4 exons and 3 introns. Exon 1 contains the 5'UTR and the ATG initiation codon. A guinea-pig gec1 cDNA was obtained by 5'-RACE. The 35...

journal_title：Biochemical and biophysical research communications

authors： Vernier-Magnin S,Muller S,Sallot M,Radom J,Musard JF,Adami P,Dulieu P,Rémy-Martin JP,Jouvenot M,Fraichard A

更新日期：2001-06-01 00:00:00

abstract：:The conversion of the endogenous cellular prion protein to an abnormally folded isoform is a hallmark of transmissible spongiform encephalopathies. It occurs when a misfolded prion protein contacts the cellular PrP. Among the molecular partners suggested to be involved in the misfolding process, the glycosaminoglycans...

journal_title：Biochemical and biophysical research communications

authors： Martin R,Chantepie S,Chapuis J,Le-Duc A,Maftah A,Papy-Garcia D,Laude H,Petit JM,Gallet PF

更新日期：2011-10-28 00:00:00

abstract：:Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a multifunctional transcription factor and an essential master gene controlling osteoblast differentiation. We previously demonstrated the in vivo functions of Runx2 in mesoderm-derived cells. However, no studies have been con...

journal_title：Biochemical and biophysical research communications

authors： Shirai Y,Kawabe K,Tosa I,Tsukamoto S,Yamada D,Takarada T

更新日期：2019-02-19 00:00:00

abstract：:Signaling by TNF-family receptor CD40 involves TRAF-family adaptor proteins, leading to activation of protein kinases that induce NFkappaB-family transcription factors. We report here that mitogen activated protein kinase kinase kinase-8 (MAP3K8), Tpl2/COT1, is recruited to the CD40 complex via a mechanism dependent o...

journal_title：Biochemical and biophysical research communications

authors： Chan H,Reed JC

更新日期：2005-03-04 00:00:00