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A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.

Abstract：

:Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Liver X receptor (LXR) alpha is known to be involved in the control of cholesterol homeostasis. Thus, the purpose of this study was to investigate the effects of 3-methlycholanthrene (MC), one of the PAHs, on LXRalpha-mediated signal transductions. We found that expression of mRNAs for ATP binding cassette A1, sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthase, and stearoyl-CoA desaturase was suppressed by treatment of HepG2 cells with MC. A luciferase reporter assay revealed that LXRalpha- and SREBP-1c-mediated transactivations were inhibited by MC via AHR. Based on these lines of evidence, we propose that down-regulation of the LXRalpha-regulated genes by PAHs is one of the causes responsible for atherosclerosis induced by PAHs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Iwano S,Nukaya M,Saito T,Asanuma F,Kamataki T

doi

10.1016/j.bbrc.2005.07.062

subject

Has Abstract

pub_date

2005-09-16 00:00:00

pages

220-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)01541-X

journal_volume

335

pub_type

杂志文章

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