The conformation formed by the domain after alanine-155 induces inversion of aspartic acid-151 in alpha A-crystallin from aged human lenses.

abstract：:The ouabain-resistant and ouabain-sensitive alpha-subunit cRNAs in various molar ratios were injected into Xenopus oocytes together with cRNA for the beta-subunit. The ouabain-resistant ATPase activity, as well as ouabain-resistant Rb+ uptake, of the injected oocytes increased linearly with increasing the amount of cR...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Kawamura M

更新日期：2001-02-09 00:00:00

abstract：:Brefeldin A (BFA), an endoplasmic reticulum (ER)-Golgi transport inhibitor, has been shown to cause accumulation of proteins in the ER, ER stress, and ultimately apoptosis. In this paper, we demonstrate that the knockdown of mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm), a mitochondrial NADPH-generat...

journal_title：Biochemical and biophysical research communications

authors： Moon JL,Kim SY,Shin SW,Park JW

更新日期：2012-01-13 00:00:00

abstract：:High serum selenium levels have been associated epidemiologically with increased incidence of type 2 diabetes. The major fraction of total selenium in serum is represented by liver-derived selenoprotein P (SeP). This study was undertaken to test for a hypothesized effect of hyperglycemia and the antihyperglycemic drug...

journal_title：Biochemical and biophysical research communications

authors： Speckmann B,Sies H,Steinbrenner H

更新日期：2009-09-11 00:00:00

abstract：:We have demonstrated the existence of two distinct subtypes of the angiotensin II receptor in the rat adrenal gland using radioligand binding and tissue section autoradiography. The identification of the subtypes was made possible by the discovery of two structurally dissimilar, nonpeptide compounds, DuP 753 and EXP65...

journal_title：Biochemical and biophysical research communications

authors： Chiu AT,Herblin WF,McCall DE,Ardecky RJ,Carini DJ,Duncia JV,Pease LJ,Wong PC,Wexler RR,Johnson AL

更新日期：1989-11-30 00:00:00

abstract：:We have constructed two phagemid vectors containing the gene coding for human Prostate Specific Antigen (PSA) translationally fused to a pelB signal sequence and minor coat protein III of phage fd leading to phage particles that carry PSA on their tips. Phages were characterized by Western blotting and by panning, usi...

journal_title：Biochemical and biophysical research communications

authors： Eerola R,Saviranta P,Lilja H,Pettersson K,Lövgren T,Karp M

更新日期：1994-05-16 00:00:00

abstract：:Human Molt3 cDNA library was constructed using pcD vector system which permits the expression of cDNA inserts in mammalian cells. Nearly full-length human terminal deoxynucleotidyltransferase (TdT) cDNA was cloned using a fragment of bovine TdT cDNA as a probe. The human TdT cDNA contains an open reading frame of 1,55...

journal_title：Biochemical and biophysical research communications

authors： Koiwai O,Kaneda T,Morishita R

更新日期：1987-04-14 00:00:00

abstract：:HSV-2 induces the transcription of c-fos gene in both human (diploid) cell strains and mouse (heteroploid) cell lines. HSV-1 is incapable of such induction. The induction of transcription is rapid and transient in both cell types. The product of transcriptional induction of c-fos in mouse cells is mainly a 4.5 kb fos ...

journal_title：Biochemical and biophysical research communications

authors： Goswami BB

更新日期：1987-03-30 00:00:00

abstract：:The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Recombinant human EPO (rhEPO) is therefore used to treat anemia in cancer patients. However, clinical trials have indicated that rhEPO treatment might promote tumor progression and has a negative effect on patient s...

journal_title：Biochemical and biophysical research communications

authors： Reinbothe S,Larsson AM,Vaapil M,Wigerup C,Sun J,Jögi A,Neumann D,Rönnstrand L,Påhlman S

更新日期：2014-02-28 00:00:00

abstract：:Mental status changes are usually associated with septic shock. However, the molecular mechanisms underlying physiological changes of the central nervous system (CNS) remain speculative. We have investigated the expression of interleukin (IL)-12, one of the central cytokines in inflammatory and immune responses, in th...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Shin SH

更新日期：1996-07-16 00:00:00

abstract：:We have investigated the status of the MTS2 gene, encoding the cyclin-dependent kinase (CDK) inhibitor p15, in 32 glioblastomas. Semi-quantitative PCR identified 7 tumors in which the amplified material was 18.6% of controls and 7 in which was 48.0%, suggesting the occurrence of homozygous and hemizygous deletions, re...

journal_title：Biochemical and biophysical research communications

authors： Tenan M,Benedetti S,Finocchiaro G

更新日期：1995-12-05 00:00:00

abstract：:We have selected calcium ionophore (A23187)-resistant cells (AR-7) in a human promyelocytic leukemia cell line, HL-60. AR-7 showed approximately 8.5-fold resistance to A23187 compared with the wild type cells after continuous exposure for 3 days. AR-7 had cross resistance to ionomycin (4.6-fold) and thapsigargin (340-...

journal_title：Biochemical and biophysical research communications

authors： Kubota M,Kataoka A,Okuda A,Bessho R,Lin YW,Wakazono Y,Usami I,Akiyama Y,Furusho K

更新日期：1995-08-15 00:00:00

abstract：:Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-kappaB signaling pathway, and nuclear transcription factor (NF)-kappaB and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific...

journal_title：Biochemical and biophysical research communications

authors： Dai W,Chen H,Jiang J,Kong W,Wang Y

更新日期：2010-01-15 00:00:00

abstract：:Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

更新日期：2016-09-23 00:00:00

abstract：:The Sec23p-Sec24p complex is a component of coat protein II-coated vesicles involved in protein export from the endoplasmic reticulum. We previously identified a novel Sec23p-interacting protein, p125, which consists of 1000 amino acids and comprises a proline-rich region and a phospholipase A(1) homology region. p125...

journal_title：Biochemical and biophysical research communications

authors： Mizoguchi T,Nakajima K,Hatsuzawa K,Nagahama M,Hauri HP,Tagaya M,Tani K

更新日期：2000-12-09 00:00:00

abstract：:The microbial degradative characteristics of butyl benzyl phthalate (BBP) were investigated by the Gordonia sp. strain MTCC 4818 isolated from creosote-contaminated soil. The test organism can utilize a number of phthalate esters as sole sources of carbon and energy, where BBP was totally degraded within 4 days under ...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee S,Dutta TK

更新日期：2003-09-12 00:00:00

abstract：:The cooperation of phosphofructokinase-2 and fructose-2,6-bisphosphatase is investigated. Experimentally derived rate laws of the kinase and bisphosphatase activities introduced into the respective differential equations permitted to describe the time evolution of fructose-2,6-bisphosphate to quasi-stationary levels. ...

journal_title：Biochemical and biophysical research communications

authors： Kretschmer M,Schellenberger W,Hofmann E

更新日期：1985-09-16 00:00:00

abstract：:Lung fibrosis is a common and serious complication of radiation therapy for lung cancer, for which there are no efficient treatments. Emerging evidence indicates that lysophosphatidic acid (LPA) and its receptors (LPARs) are involved in the pathogenesis of fibrosis. Here, we reported that thoracic radiation with 16Gy ...

journal_title：Biochemical and biophysical research communications

authors： Gan L,Xue JX,Li X,Liu DS,Ge Y,Ni PY,Deng L,Lu Y,Jiang W

更新日期：2011-05-27 00:00:00

abstract：:The tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL or Apo2L) and its receptors are members of the tumor necrosis factor superfamily. TRAIL triggers apoptosis by binding to its two proapoptotic receptors DR4 and DR5, a process which is negatively regulated by binding of TRAIL to its two decoy rece...

journal_title：Biochemical and biophysical research communications

authors： Sun SY,Yue P,Zhou JY,Wang Y,Choi Kim HR,Lotan R,Wu GS

更新日期：2001-01-26 00:00:00

abstract：:EcoP1I methyltransferase (M.EcoP1I) belongs to the type III restriction-modification system encoded by prophage P1 that infects Escherichia coli. Binding of M.EcoP1I to double-stranded DNA and single-stranded DNA has been characterized. Binding to both single- and double-stranded DNA could be competed out by unlabeled...

journal_title：Biochemical and biophysical research communications

authors： Sistla S,Krishnamurthy V,Rao DN

更新日期：2004-01-30 00:00:00

abstract：:Endotoxemia is characterized by multiple dysfunctions of the micro-vascular endothelium. Of these, vascular leakage is an initial event that aggravates vascular dysfunction can lead to systemic vascular collapse and organ failure. Thus, prevention of vascular leakage may ameliorate endotoxin-induced dysfunctions of bl...

journal_title：Biochemical and biophysical research communications

authors： Hwang JA,Lee EH,Lee SD,Park JB,Jeon BH,Cho CH

更新日期：2009-04-17 00:00:00

abstract：:S-Adenosyl-l-methionine (SAM) is the biological methyl-group donor for the enzymatic methylation of numerous substrates including proteins. SAM has been reported to activate smooth muscle derived ryanodine receptor calcium release channels. Therefore, we examined the effects of SAM on the cardiac isoform of the ryanod...

journal_title：Biochemical and biophysical research communications

authors： Kampfer AJ,Balog EM

更新日期：2008-07-11 00:00:00

abstract：:Arrhythmogenic right ventricular dysplasia/cardiomyopathy type 2 (ARVD2, OMIM 600996) and stress-induced polymorphic ventricular tachycardia (VTSIP, OMIM 604772) are two cardiac diseases causing juvenile sudden death, both associated with mutations in the RyR2 calcium channel. By using a quantitative yeast two-hybrid ...

journal_title：Biochemical and biophysical research communications

authors： Tiso N,Salamon M,Bagattin A,Danieli GA,Argenton F,Bortolussi M

更新日期：2002-12-13 00:00:00

abstract：:The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. ...

journal_title：Biochemical and biophysical research communications

authors： Khan MH,Hart MJ,Rea SL

更新日期：2012-08-24 00:00:00

abstract：:Galectin-9 exhibited potent and selective eosinophil chemoattractant activity and attracted eosinophils in vitro and in vivo. Nasal polyposis is a chronic inflammatory disease of the upper airway characterized by the marked presence of inflammatory cells, particularly eosinophils. Thus, galectin-9 may be implicated in...

journal_title：Biochemical and biophysical research communications

authors： Park WS,Jung WK,Park SK,Heo KW,Kang MS,Choi YH,Kim GY,Park SG,Seo SK,Yea SS,Liu KH,Shim EB,Kim DJ,Her M,Choi IW

更新日期：2011-07-29 00:00:00

abstract：:Many amplified-chromosome regions in human cancers have been identified, while there are only a limited number of reports for amplified genes in a single amplicon. We recently isolated four cDNA clones, A39, B47, C51, and CAB1, from 500 kilobases of yeast artificial chromosome DNA containing the c-ERBB-2 gene. B47 con...

journal_title：Biochemical and biophysical research communications

authors： Kishi T,Sasaki H,Akiyama N,Ishizuka T,Sakamoto H,Aizawa S,Sugimura T,Terada M

更新日期：1997-03-06 00:00:00

abstract：:Reactive oxygen species (ROS) play a crucial role in various physiological and pathological processes mediated by β-adrenergic receptors (β-ARs) in cardiomyocytes. However, the sources and signaling pathways involved in ROS production induced by acute β-AR activation have not yet been fully defined. In primary neonata...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Xiao H,Shen J,Wang N,Zhang Y

更新日期：2017-08-05 00:00:00

abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

journal_title：Biochemical and biophysical research communications

authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

更新日期：1996-06-05 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Wang H,Duan Y,Yang H

更新日期：2020-11-21 00:00:00

abstract：:The E2F activity plays a critical role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. We describe here molecular cloning and functional characterization of a fifth member of the E2F family of transcription factors. E2F-...

journal_title：Biochemical and biophysical research communications

authors： Vaishnav YN,Vaishnav MY,Pant V

更新日期：1998-01-26 00:00:00

abstract：:It has been suggested that curcumin and other sarcoplasmic/endoplasmic reticulum Ca(2+)-pump inhibitors could correct the defect in the most common mutation (DeltaF508) in cystic fibrosis (CF), and restore normal chloride transport. In the present study, the effect of curcumin was tested on baby hamster kidney (BHK) c...

journal_title：Biochemical and biophysical research communications

authors： Dragomir A,Björstad J,Hjelte L,Roomans GM

更新日期：2004-09-17 00:00:00