Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer.

abstract：:The NUCKS gene is located on human chromosome 1q32.1 and consists of seven exons and six introns. The gene lacks a TATA box but contains two Inr elements, two GC boxes, and one consensus-binding site for E2F-1. NUCKS is expressed in all human adult and foetal tissues investigated, and has all the features of being a h...

journal_title：Biochemical and biophysical research communications

authors： Grundt K,Haga IV,Aleporou-Marinou V,Drosos Y,Wanvik B,Østvold AC

更新日期：2004-10-22 00:00:00

abstract：:In the present study, we demonstrated that Ang II provokes a transitory enhancement of focal adhesion kinase (FAK) and paxillin phosphorylation in human umbilical endothelial cells (HUVEC). Moreover, Ang II induces a time- and dose-dependent augmentation in cell migration, but does not affect HUVEC proliferation. The ...

journal_title：Biochemical and biophysical research communications

authors： Montiel M,de la Blanca EP,Jiménez E

更新日期：2005-02-25 00:00:00

abstract：:Major blood stage antimalarial drugs like chloroquine and artemisinin target the heme detoxification process of the malaria parasite. Hemozoin formation reactions in vitro using the Plasmodium falciparum histidine-rich protein-2 (Pfhrp-2), lipids, and auto-catalysis are slow and could not explain the speed of detoxifi...

journal_title：Biochemical and biophysical research communications

authors： Pandey AV,Babbarwal VK,Okoyeh JN,Joshi RM,Puri SK,Singh RL,Chauhan VS

更新日期：2003-09-05 00:00:00

abstract：:We have previously described the patterns of stress kinase activation in rat kidney and heart in response to ischemia/reperfusion (Yin et al., 1997, J. Biol. Chem. 272, 19943-19950). During the course of these studies, we observed the activation of a novel kinase capable of phosphorylating c-Jun on serines 63 and 73. ...

journal_title：Biochemical and biophysical research communications

authors： De Silva H,Cioffi C,Yin T,Sandhu G,Webb RL,Whelan J

更新日期：1998-09-29 00:00:00

abstract：:To characterize genes involved in megakaryocytic commitment, we compared expression profiles of bipotent cells (UT-7/c-mpl) with those of the same cells induced to differentiate towards megakaryopoiesis in the presence of TPO. Using cDNA arrays, we showed that 12 out of 2260 genes changed their expression level after ...

journal_title：Biochemical and biophysical research communications

authors： Decraene C,Garçon L,Lacout C,Sabri S,Auffray C,Vainchenker W,Duménil D,Piétu G,Svinartchuk F

更新日期：2004-05-28 00:00:00

abstract：:Locally applied radiation to the tumor is reported to stimulate systemic immune response. During radiotherapy to the abdominal cancer, spleen often receives certain dose, though as an important immune organ, little is known about the impact of splenic irradiation (SI) on systemic immune and local tumor control. Throug...

journal_title：Biochemical and biophysical research communications

authors： Chen HY,Xie HY,Liu XX,Li LF,Bai YR,Gao JX

更新日期：2019-02-26 00:00:00

abstract：:Using an oligonucleotide hybridization assay to gain insight into the folding of delta ribozymes, we demonstrate a correlation between their folding and catalytic behavior. Together with recent structural information on the crystal structure of self-cleaved genomic delta ribozyme, in which the L3 loop interacts with J...

journal_title：Biochemical and biophysical research communications

authors： Ananvoranich S,Perreault JP

更新日期：2000-04-13 00:00:00

abstract：:Hepatocytes isolated from normal adult rats were maintained at sub-confluent density in a defined medium in primary culture. In control cultures with added epidermal growth factor and low concentrations of dexamethasone, the rate of DNA synthesis was initially low but increased after about 30 hours in culture. Additio...

journal_title：Biochemical and biophysical research communications

authors： Edwards AM,Lucas CM

更新日期：1985-08-30 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation t(15;17), which results in the fusion of the promyelocytic leukemia gene (PML) and retinoic acid receptor alpha gene (RARalpha). APL can be effectively treated with the cell differentiation inducer all-trans retinoic acid (ATRA)...

journal_title：Biochemical and biophysical research communications

authors： Lee KH,Chang MY,Ahn JI,Yu DH,Jung SS,Choi JH,Noh YH,Lee YS,Ahn MJ

更新日期：2002-09-06 00:00:00

abstract：:Calcium is found a strong stimulator of sulfite reduction from hydrogen. A coupling protein of molecular weight 65,000 can be isolated from Desulfovibrio gigas. It functions in a reconstituted electron transfer chain between hydrogenase and sulfite reductase. Its N-terminal sequence shows high homologies with calcium ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Liu MY,Le Gall J

更新日期：1991-10-15 00:00:00

abstract：:cDNAs encoding the long-chain acyl-CoA hydrolases (ACHs) from rat brain and liver, referred to as rBACH and rLACH1, respectively, were isolated and sequenced. The rBACH cDNA contained an open reading frame encoding a 338-amino acid polypeptide with a calculated molecular weight of 37,559, of which the deduced amino ac...

journal_title：Biochemical and biophysical research communications

authors： Yamada J,Furihata T,Iida N,Watanabe T,Hosokawa M,Satoh T,Someya A,Nagaoka I,Suga T

更新日期：1997-03-06 00:00:00

abstract：:In the brains of Alzheimer's disease patients, the tau protein abnormally aggregates to form an insoluble paired helical filament (PHF). Since the third repeat structure (R3) of the tau microtubule-binding domain plays an essential role in PHF formation and self-aggregates most significantly in an aqueous solution of ...

journal_title：Biochemical and biophysical research communications

authors： Minoura K,Mizushima F,Tokimasa M,Hiraoka S,Tomoo K,Sumida M,Taniguchi T,Ishida T

更新日期：2005-02-25 00:00:00

abstract：:Myostatin belongs to the transforming growth factor (TGF)-beta superfamily and is a potent negative regulator of skeletal muscle development and growth. We utilized microinjection of an antisense RNA-expressing vector to establish a hereditarily stable myostatin gene knockdown zebrafish strain with a double-muscle phe...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Hu SY,Gong HY,Chen MH,Lu JK,Wu JL

更新日期：2009-10-02 00:00:00

abstract：:Linoleic acid, an omega-6 unsaturated fatty acid, stimulated growth of the MDA-MB-231 and MCF-7 human breast cancer cell lines in culture. Responses of the estrogen-independent MDA-MB-231 cells both in serum-free medium and with 1% fetal bovine serum added were positively correlated with linoleic acid concentration ov...

journal_title：Biochemical and biophysical research communications

authors： Rose DP,Connolly JM

更新日期：1989-10-16 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the pancreatic carcinogenesis and progression. In the present study, we found that miR-9-5p was significantly downregulated in pancreatic cancer tissues and cell lines. The expression levels of miR-9-5p were negatively correlated with tumor stage and vessel invasion. Log-rank t...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Wang B,Ren H,Chen W

更新日期：2019-01-29 00:00:00

abstract：:Multidrug resistance protein 1 (MRP1/ABCC1) is a 190kDa member of the ATP-binding cassette (ABC) superfamily of transmembrane transporters that is clinically relevant for its ability to confer multidrug resistance by actively effluxing anticancer drugs. Knowledge of the atomic structure of MRP1 is needed to elucidate ...

journal_title：Biochemical and biophysical research communications

authors： DeGorter MK,Conseil G,Deeley RG,Campbell RL,Cole SP

更新日期：2008-01-04 00:00:00

abstract：:The molecular sizes of histamine H1-receptors of rat, rabbit, human, pig, guinea-pig, chicken, dog, and bovine liver were investigated by radiation inactivation and determined to be 100,000 to 160,000 daltons in all the animals examined. Statistical analysis showed that the hepatic H1-receptors have a common size of 1...

journal_title：Biochemical and biophysical research communications

authors： Wang NP,Fukui H,Matsuoka H,Wada H

更新日期：1986-06-13 00:00:00

abstract：:Purified bovine adrenal P-45011 beta has been shown to catalyze conversions of cortisol to cortisone (11-oxidase activity), and 19-hydroxyandrostenedione to 19-oxoandrostenedione (19-oxidase activity), in the reconstituted system consisting of NADPH, NADPH:adrenodoxin reductase, and adrenodoxin. The turnover numbers (...

journal_title：Biochemical and biophysical research communications

authors： Suhara K,Takeda K,Katagiri M

更新日期：1986-04-14 00:00:00

abstract：:In cells, there exists a delicate balance between accumulation of charged metal cations and abundant anionic complexes such as phosphate. When phosphate metabolism is disrupted, cell-wide spread disturbances in metal homeostasis may ensue. The best example is a yeast pho80 mutant that hyperaccumulates phosphate and as...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld L,Culotta VC

更新日期：2012-02-10 00:00:00

abstract：:We have recently shown that optimal growth temperature (T(opt)) is one of the factors that influence genomic GC in prokaryotes. Our results have been disputed by Marashi and Ghalanbor, who claim that the correlations we show are not "robust" because the elimination of some points (arbitrarily chosen) leads, in some fa...

journal_title：Biochemical and biophysical research communications

authors： Musto H,Naya H,Zavala A,Romero H,Alvarez-Valin F,Bernardi G

更新日期：2005-05-06 00:00:00

abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

journal_title：Biochemical and biophysical research communications

authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

更新日期：2007-06-29 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively regulates G(0/1) progression and plays a major role in controlling the cell cycle. The screening of the p27(Kip1) sequence identified many potential phosphorylation sites. Although Ser(10) and Thr...

journal_title：Biochemical and biophysical research communications

authors： Guan X,Chen L,Wang J,Geng H,Chu X,Zhang Q,Du L,De W

更新日期：2006-09-01 00:00:00

abstract：:Isolated Agrobacterium tumefaciens was exposed to different extremely low frequencies of square amplitude modulated waves (QAMW) from two generators to determine the resonance frequency that causes growth inhibition. The carrier was 10 MHz sine wave with amplitude ±10 Vpp which was modulated by a second wave generator...

journal_title：Biochemical and biophysical research communications

authors： Fadel MA,El-Gebaly RH,Mohamed SA,Abdelbacki AMM

更新日期：2017-12-09 00:00:00

abstract：:We report on a system to improve expression of mature c-type cytochromes in Escherichia coli. It is based on the use of plasmid pEC86 that expresses the E. coli cytochrome c maturation genes ccmABCDEFGH constitutively, whereby the production of both endogenous and foreign c-type cytochromes was increased substantially...

journal_title：Biochemical and biophysical research communications

authors： Arslan E,Schulz H,Zufferey R,Künzler P,Thöny-Meyer L

更新日期：1998-10-29 00:00:00

abstract：:Cell motility and cell stiffness are closely related to metastatic activity of cancer cells. (-)-Epigallocatechin gallate (EGCG) has been shown to inhibit spontaneous metastasis of melanoma cell line into the lungs of mice, so we studied the effects of EGCG on cell motility, cell stiffness, and expression of vimentin ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi A,Watanabe T,Mondal A,Suzuki K,Kurusu-Kanno M,Li Z,Yamazaki T,Fujiki H,Suganuma M

更新日期：2014-01-03 00:00:00

abstract：:It is noteworthy that the formation of the DNA G-quadruplex is induced by factors other than stabilizing cations because this event probably occurs in living cells. Previous studies have shown that thrombin-binding DNA aptamer (TBA) forms a chair-type intramolecular G-quadruplex structure that binds with thrombin prot...

journal_title：Biochemical and biophysical research communications

authors： Nagatoishi S,Tanaka Y,Tsumoto K

更新日期：2007-01-19 00:00:00

abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

journal_title：Biochemical and biophysical research communications

authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

更新日期：2011-10-28 00:00:00

abstract：:The isolation of the genes located in chromosome 21 and the characterisation of their function are essential steps towards the understanding of the physiopathological mechanisms involved in Down syndrome. We have used two complementary approaches to characterise the function of the novel gene DSCR2 (Down Syndrome Crit...

journal_title：Biochemical and biophysical research communications

authors： Vidal-Taboada JM,Lu A,Pique M,Pons G,Gil J,Oliva R

更新日期：2000-05-27 00:00:00

abstract：:PP2Cgamma is a splicing factor that dephosphorylates specific substrates required for the formation of the spliceosome. In a previous study, we reported that the degradation of p21(Cip1/WAF1)was affected by PP2Cgamma, causing an accumulation of cells in S phase. Here, we demonstrate that the PP2Cgamma-induced degradat...

journal_title：Biochemical and biophysical research communications

authors： Suh EJ,Kim YJ,Kim SH

更新日期：2009-08-28 00:00:00