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Determination of the molecular size of the hepatic H1-receptor by target size analysis.

Abstract：

:The molecular sizes of histamine H1-receptors of rat, rabbit, human, pig, guinea-pig, chicken, dog, and bovine liver were investigated by radiation inactivation and determined to be 100,000 to 160,000 daltons in all the animals examined. Statistical analysis showed that the hepatic H1-receptors have a common size of 128,000 +/- 63,000 daltons. Saturation analysis showed that the [3H]mepyramine binding constant was not changed by irradiation, while the binding capacity decreased with increase in the radiation dose.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang NP,Fukui H,Matsuoka H,Wada H

doi

10.1016/0006-291x(86)91119-8

subject

Has Abstract

pub_date

1986-06-13 00:00:00

pages

593-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)91119-8

journal_volume

137

pub_type

杂志文章

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