Dissect Kif5b in nuclear positioning during myogenesis: the light chain binding domain and the autoinhibitory peptide are both indispensable.

abstract：:In eukaryotes, LAMMER kinases are involved in various cellular events, including the cell cycle. However, no attempt has been made to investigate the mechanisms that underlie the involvement of LAMMER kinase. In this study, we performed a functional analysis of LAMMER kinase using the fission yeast, Schizosaccharomyce...

journal_title：Biochemical and biophysical research communications

authors： Yu EY,Lee JH,Kang WH,Park YH,Kim L,Park HM

更新日期：2013-03-01 00:00:00

abstract：:The wound healing process is initiated as soon as tissue is injured. Herein, we demonstrate that c-fos and c-myc mRNA transcripts are promptly increased in the wounded tissue in vivo and in vitro. A buffer solution from scraped serum-starved quiescent fibroblasts, when added to resting fibroblasts, caused the increase...

journal_title：Biochemical and biophysical research communications

authors： Tsuboi K,Yamaoka S,Maki M,Ohshio G,Tobe T,Hatanaka M

更新日期：1990-05-16 00:00:00

abstract：:The fungal AAL-toxin triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin due to the knockout of a gene involved in sphingolipid metab...

journal_title：Biochemical and biophysical research communications

authors： Gechev TS,Ferwerda MA,Mehterov N,Laloi C,Qureshi MK,Hille J

更新日期：2008-10-31 00:00:00

abstract：:Anchoring protein alphaKAP targets calmodulin kinase II (CaMKII) to the sarcoplasmic reticulum (SR), and in the rabbit is a substrate of CaMKII itself in fast-twitch, but not in slow-twitch muscle. This work was aimed at elucidating the molecular basis for differential phosphorylation of alphaKAP. Here we show that tw...

journal_title：Biochemical and biophysical research communications

authors： Damiani E,Sacchetto R,Salviati L,Margreth A

更新日期：2003-02-28 00:00:00

abstract：:CARMA3 was recently reported to be overexpressed in cancers and associated with the malignant behavior of cancer cells. However, the expression of CARMA3 and its biological roles in colon cancer have not been reported. In the present study, we analyzed the expression pattern of CARMA3 in colon cancer tissues and found...

journal_title：Biochemical and biophysical research communications

authors： Miao Z,Zhao T,Wang Z,Xu Y,Song Y,Wu J,Xu H

更新日期：2012-09-07 00:00:00

abstract：:IRE1α (Inositol-requiring enzyme 1 α), an endoplasmic reticulum (ER)-resident sensor for mammalian unfolded protein response, is a type I transmembrane protein which has a bifunctional enzyme containing kinase and RNase domains. Although the luminal domain and cytosolic domain of IRE1α are thought to play crucial role...

journal_title：Biochemical and biophysical research communications

authors： Cho H,Lamarca R,Chan C

更新日期：2012-11-02 00:00:00

abstract：:The nuclear enzyme poly(ADP-ribosyl) transferase (pADPRT) catalyzes the formation of poly(ADP-ribose) from NAD+. Several nuclear proteins and pADPRT itself are targets for the modification by poly(ADP-ribosyl)ation. It is demonstrated here that poly(ADP-ribose) or pADPRT automodified with poly(ADP-ribose) interacts no...

journal_title：Biochemical and biophysical research communications

authors： Mayer-Kuckuk P,Ullrich O,Ziegler M,Grune T,Schweiger M

更新日期：1999-06-16 00:00:00

abstract：:Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and underlying mechanisms in the development and progression of colorectal carcinoma has not been elucidated clearly. Here, we performed real-time PCR ...

journal_title：Biochemical and biophysical research communications

authors： Sun JY,Huang Y,Li JP,Zhang X,Wang L,Meng YL,Yan B,Bian YQ,Zhao J,Wang WZ,Yang AG,Zhang R

更新日期：2012-04-20 00:00:00

abstract：:Since we recently reported that high density lipoprotein, which contains the bioactive lipid sphingosine-1-phosphate (S1P) [Arterioscler. Thromb. Vasc. Biol. 23 (2003) 802], induced human coronary artery endothelial cell (HCEC) tube formation mediated by a Ras/Raf/ERK (extracellular signal-activated kinase) pathway, w...

journal_title：Biochemical and biophysical research communications

authors： Miura S,Tanigawa H,Matsuo Y,Fujino M,Kawamura A,Saku K

更新日期：2003-07-11 00:00:00

abstract：:Based on a previous finding that fusion of a somatic cell with an embryonic stem (ES) cell reprogrammed the somatic cell, genes for reprogramming transcription factors were selected and induced pluripotent stem (iPS) cell technology was developed. The cell fusion itself produced a tetraploid cell. To avoid nuclear fus...

journal_title：Biochemical and biophysical research communications

authors： Kim SM,Wada KI,Ueki M,Hosokawa K,Maeda M,Sakai Y,Ito Y

更新日期：2019-12-03 00:00:00

abstract：:Fatty Acid Synthase (FASN), a 250-kDa cytosolic multi-enzyme catalyzing eukaryotic de novo FA biogenesis, unexpectedly localizes in cancer cell culture supernatants and in the blood of cancer patients. High levels of "extracellular FASN" have recently been found in supernatants from Hepatitis C Virus-infected liver ce...

journal_title：Biochemical and biophysical research communications

authors： Oliveras-Ferraros C,Vazquez-Martin A,Fernández-Real JM,Menendez JA

更新日期：2009-01-16 00:00:00

abstract：:Antitrypsin was resolved into two pools by ion-exchange chromatography. Pool 2 contained three anodal isoinhibitors and an N-terminal sequence identical with the one found by others. Pool 1 contained, in addition to the anodal ones two cathodal isoinhibitors as well. The sequencing data of Pool 1 indicate that the cat...

journal_title：Biochemical and biophysical research communications

authors： Hercz A

更新日期：1985-04-16 00:00:00

abstract：BACKGROUND/AIMS:Pancreatic islet transplantation is an effective treatment for Type 1 diabetic patients to eliminate insulin injections; however, a shortage of donor organs hinders the widespread use. Although long-term islet storage, such as cryopreservation, is considered one of the key solutions, transplantation of ...

journal_title：Biochemical and biophysical research communications

authors： Komatsu H,Barriga A,Medrano L,Omori K,Kandeel F,Mullen Y

更新日期：2017-05-06 00:00:00

abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

journal_title：Biochemical and biophysical research communications

authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

更新日期：1999-09-07 00:00:00

abstract：:Isoliquiritigenin (ILTG) is a chalcone compound and has valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer, and antiallergic activities. Recently, the anxiolytic effect of ILTG has been reported; however, its action mechanism and hypnotic activity have not yet been demonstrated. The...

journal_title：Biochemical and biophysical research communications

authors： Cho S,Kim S,Jin Z,Yang H,Han D,Baek NI,Jo J,Cho CW,Park JH,Shimizu M,Jin YH

更新日期：2011-10-07 00:00:00

abstract：:Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and generates the second messenger cyclic GMP (cGMP). Recently, purified sGC α1β1 has been shown to additionally generate the cyclic pyrimidine nucleotides cCMP and cUMP. However, since cyclic pyrimidine nucleotide formation occurred only the presence of...

journal_title：Biochemical and biophysical research communications

authors： Bähre H,Danker KY,Stasch JP,Kaever V,Seifert R

更新日期：2014-01-24 00:00:00

abstract：:Brassica campestris Male Fertility 20 (BcMF20) is a typical zinc-finger transcription factor that was previously isolated from flower buds of Chinese cabbage (Brassica campestris ssp. chinensis). By applying expression pattern analysis, it can be known that BcMF20 was specifically and strongly expressed in tapetum and...

journal_title：Biochemical and biophysical research communications

authors： Han YY,Zhou HY,Xu LA,Liu XY,Fan SX,Cao JS

更新日期：2018-09-05 00:00:00

abstract：:We have identified two neuropeptides (F1 and F2) from suboesophageal and thoracic ganglia of Locusta migratoria, which we isolated earlier based on their immunological similarity to arginine vasopressin. The more abundant and hydrophilic factor, F1, has sequence Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2, but its biologi...

journal_title：Biochemical and biophysical research communications

authors： Proux JP,Miller CA,Li JP,Carney RL,Girardie A,Delaage M,Schooley DA

更新日期：1987-11-30 00:00:00

abstract：:Calmodulin is phosphorylated by casein kinase II on Thr-79, Ser-81, Ser-101 and Thr-117. To determine the consensus sequences for casein kinase II in intact calmodulin, we examined casein kinase II-mediated phosphorylation of engineered calmodulins with 1-4 deletions in the central helical region (positions 81-84). To...

journal_title：Biochemical and biophysical research communications

authors： Sacks DB,Davis HW,Crimmins DL,Persechini A,McDonald JM

更新日期：1992-10-30 00:00:00

abstract：:The effect of eicosapentaenoic acid (EPA) on natural killer (NK) cell activity of human lymphocytes was examined. The addition of an emulsion of trieicosapentaenoyl-glycerol (EPA-TG) emulsified with purified phosphatidylcholine from krill to a cytotoxicity assay system resulted in a marked depression of NK activity. T...

journal_title：Biochemical and biophysical research communications

authors： Yamashita N,Yokoyama A,Hamazaki T,Yano S

更新日期：1986-08-14 00:00:00

abstract：:The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential d...

journal_title：Biochemical and biophysical research communications

authors： Zhu Z,Burnett CM,Maksymov G,Stepniak E,Sierra A,Subbotina E,Anderson ME,Coetzee WA,Hodgson-Zingman DM,Zingman LV

更新日期：2011-12-02 00:00:00

abstract：:Endogenous cysteine proteases were given much attention lately, as their role in a variety of pathophysiological disorders became evident. Amongst them cathepsins, which are thought to be implicated in mediation of osteoporosis, cancer progression, atherosclerosis, and many other conditions, are of considerable intere...

journal_title：Biochemical and biophysical research communications

authors： Bratkovic T,Lunder M,Popovic T,Kreft S,Turk B,Strukelj B,Urleb U

更新日期：2005-07-08 00:00:00

abstract：:We isolated mouse CPP32/apopain cDNA, a mammalian homologue most closely related to Ced-3 in C. elegans, and examined the involvement of CPP32 in the apoptosis of nervous system during development. CPP32 is specifically expressed in the trigeminal (V) ganglia, facio-acoustic (VII-VIII) ganglion complex, and dorsal roo...

journal_title：Biochemical and biophysical research communications

authors： Mukasa T,Urase K,Momoi MY,Kimura I,Momoi T

更新日期：1997-02-24 00:00:00

abstract：:Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study hypothesized that this adaptive response is mediated by increased mRNA of key genes central to the regulation of fat oxidati...

journal_title：Biochemical and biophysical research communications

authors： Tunstall RJ,Mehan KA,Hargreaves M,Spriet LL,Cameron-Smith D

更新日期：2002-06-07 00:00:00

abstract：:MicroRNA (miRNA)-mediated gene silencing has recently emerged as a major mechanism of gene expression regulation during development in a variety of species. Little is known, however, about the presence of components of miRNA machinery in mammalian organogenesis. In this study, we report that members of the Argonaute (...

journal_title：Biochemical and biophysical research communications

authors： Lü J,Qian J,Chen F,Tang X,Li C,Cardoso WV

更新日期：2005-08-26 00:00:00

abstract：:Strategies that antagonize growth factor signaling are attractive candidates for the biological therapy of brain tumors. HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of sol...

journal_title：Biochemical and biophysical research communications

authors： Guerin C,Luddy C,Abounader R,Lal B,Laterra J

更新日期：2000-06-24 00:00:00

abstract：:Glycosaminoglycans were prepared as salts of different divalent cations and tested as donors in bovine testicular hyaluronidase catalyzed transglycosylation reactions. All of the metal cations examined had similar binding efficiency of divalent cations to hyaluronan. However, cations bound with different efficiencies ...

journal_title：Biochemical and biophysical research communications

authors： Kakizaki I,Nukatsuka I,Takagaki K,Majima M,Iwafune M,Suto S,Endo M

更新日期：2011-03-11 00:00:00

abstract：:The catalytic C-C bond cleavage of a lignin model compound was investigated by use of tetraphenylporphyrinatoiron(III)chloride as a model for enzymic degradation of lignin. The C-C bond of the lignin model compound 1,2-bis(4-ethoxy-3-methoxyphenyl) propane-1,3-diol was oxidatively cleaved by catalysis of iron-porphyri...

journal_title：Biochemical and biophysical research communications

authors： Shimada M,Habe T,Umezawa T,Higuchi T,Okamoto T

更新日期：1984-08-16 00:00:00

abstract：:Glioma is one of the most common primary brain tumors in adults with a high mortality rate and relapse rate. Thus, finding better effective approaches to treat glioma has become very urgent. Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain can...

journal_title：Biochemical and biophysical research communications

authors： Li B,Wang F,Liu N,Shen W,Huang T

更新日期：2017-09-09 00:00:00

abstract：:We have extracted and purified proteins from calcium containing urinary stones with 4 M guanidine chloride and sequenced the amino acids of the proteins. The protein of approximately 49kDa was defined as human alpha-one antitrypsin (AT, from 23rd to 42nd amino acids of NH2-terminal) by amino acid sequence analysis. Th...

journal_title：Biochemical and biophysical research communications

authors： Umekawa T,Kohri K,Amasaki N,Yamate T,Yoshida K,Yamamoto K,Suzuki Y,Sinohara H,Kurita T

更新日期：1993-06-30 00:00:00