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1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes.

Abstract：

:The effect of 1-bromlalkanes on intracellular glutathione (GSH) was studied in freshly isolated rat hepatocytes. Treatment of cells with bromoalkanes depleted cellular GSH levels without causing cytotoxicity. The extent of GSH depletion was directly proportional to the concentration and increasing chain length of 1-bromoalkanes (C2-C7). Bromoheptane (100 microM) depleted GSH by 87% in 30 mins which remained depleted for the 4 hr study period without causing cytotoxicity. A 30 fold higher concentration of bromoheptane was required before cytotoxicity ensued. Bromoheptane would therefore be particularly useful for studying the role of GSH in modulating xenobiotic cytotoxicity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Khan S,O'Brien PJ

doi

10.1016/0006-291x(91)91389-t

subject

Has Abstract

pub_date

1991-08-30 00:00:00

pages

436-41

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91389-T

journal_volume

179

pub_type

杂志文章

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