Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss.

abstract：:A comparison was made of cytosynalin- and MAPs-induced microtubule formation. Cytosynalin (a 35 kDa cytoskeleton-interacting and calmodulin-binding protein) facilitated more rapid and extensive microtubule formation than MAPs. Electron microscopic examination revealed that the cytosynalin-induced microtubules were 24 ...

journal_title：Biochemical and biophysical research communications

authors： Itoh K,Sobue K

更新日期：1987-07-31 00:00:00

abstract：:Here we enhanced the stability and biophysical properties of mRFP1 through a combination of canonical and non-canonical amino acid mutagenesis. The global replacement of proline residue with (2S, 4R)-4-fluoroproline [(4R)-FP] into mRFP1 led to soluble protein but lost its fluorescence, whereas (2S, 4S)-4-fluoroproline...

journal_title：Biochemical and biophysical research communications

authors： Deepankumar K,Nadarajan SP,Ayyadurai N,Yun H

更新日期：2013-11-01 00:00:00

abstract：:The human ST2 gene has been known to encode three splice variants; namely, a soluble secreted form of ST2, a transmembrane form of ST2L, and ST2V of undetermined localization. Therefore, analysis of tissue distribution and subcellular localization of ST2V is important to elucidate functional relationships among the th...

journal_title：Biochemical and biophysical research communications

authors： Tago K,Noda T,Hayakawa M,Iwahana H,Yanagisawa K,Yashiro T,Tominaga S

更新日期：2001-08-03 00:00:00

abstract：:The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential d...

journal_title：Biochemical and biophysical research communications

authors： Zhu Z,Burnett CM,Maksymov G,Stepniak E,Sierra A,Subbotina E,Anderson ME,Coetzee WA,Hodgson-Zingman DM,Zingman LV

更新日期：2011-12-02 00:00:00

abstract：:The rat Bone/Liver/kidney/Placenta Alkaline Phosphatase (ALP) is transcribed from two alternative promoters spaced over 25 kb apart, resulting in two variant transcripts that are identical in their coding sequence. We investigated the steady-state levels of the two variant transcripts in various rat tissues and cell l...

journal_title：Biochemical and biophysical research communications

authors： Zernik J,Kream B,Twarog K

更新日期：1991-05-15 00:00:00

abstract：:Intestinal epithelial cells participate in an acute phase response (APR) by responding to cytokines and by expressing acute phase protein genes. We hypothesized that butyrate, a fermentation product of the bacterial intestinal flora with deacetylase activity, affects the APR in intestinal epithelial cells. Sodium buty...

journal_title：Biochemical and biophysical research communications

authors： Désilets A,Gheorghiu I,Yu SJ,Seidman EG,Asselin C

更新日期：2000-09-24 00:00:00

abstract：:The NC1 domains from the different α(IV) collagen chains were found to exert anti-tumorigenic and/or anti-angiogenic activities. A limitation to the therapeutic use of these matrikines is the large amount of purified recombinant proteins, in the milligram range in mice that should be administered daily throughout the ...

journal_title：Biochemical and biophysical research communications

authors： Thevenard J,Ramont L,Mir LM,Dupont-Deshorgue A,Maquart FX,Monboisse JC,Brassart-Pasco S

更新日期：2013-03-22 00:00:00

abstract：:Sheep thyroid cells cultured in serum-free medium were used to study the biologic activity, binding, and production of the insulin-like growth factors (IGFs). IGF-I, IGF-II, and insulin stimulated thyroid cell division. Abundant, specific IGF receptors on sheep thyroid cell membranes were identified by binding displac...

journal_title：Biochemical and biophysical research communications

authors： Bachrach LK,Eggo MC,Hintz RL,Burrow GN

更新日期：1988-08-15 00:00:00

abstract：:Oncogenic osteomalacia (OOM), X-linked hypophosphatemia (XLH), and autosomal dominant hypophosphatemic rickets (ADHR) are phenotypically similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum calcitriol concentrations, normal serum concentrations of calcium and...

journal_title：Biochemical and biophysical research communications

authors： Bowe AE,Finnegan R,Jan de Beur SM,Cho J,Levine MA,Kumar R,Schiavi SC

更新日期：2001-06-22 00:00:00

abstract：:Human follitropin receptor (hFSHR) cDNA was inserted into the genome of Autographa californica nuclear polyhedrosis virus under the control of the polyhedrin promoter. Spodoptera frugiperda (Sf9) insect cells expressed the hFSHR at the membrane level, 2-3 days after infection. Ligand binding analysis demonstrated satu...

journal_title：Biochemical and biophysical research communications

authors： Christophe S,Robert P,Maugain S,Bellet D,Koman A,Bidart JM

更新日期：1993-10-15 00:00:00

abstract：:Interleukin-17 is a T-cell-derived pro-inflammatory cytokine, exhibiting multiple biological activities in a variety of cells and believed to fine tune all general phases of hematopoietic response. However, the signaling mechanism of this novel cytokine remains unknown. Here, we report for the first time that the earl...

journal_title：Biochemical and biophysical research communications

authors： Subramaniam SV,Cooper RS,Adunyah SE

更新日期：1999-08-19 00:00:00

abstract：:Expression of facilitative glucose transporters (Glut 1, 2 and 3) was examined by Western blot analyses 10, 20 and 30 days following surgically induced unilateral abdominal cryptorchidism. The cryptorchid testes exhibited marked degenerative changes in the seminiferous tubules and spermatogonia, impaired and incomplet...

journal_title：Biochemical and biophysical research communications

authors： Farooqui SM,Al-Bagdadi F,O'Donnell JM,Stout R

更新日期：1997-07-18 00:00:00

abstract：:We found a novel protein-protein interaction between ubiquitin-specific protease 15 (USP15) and skeletal muscle LIM protein 1 (SLIM1): USP15 and SLIM1 directly bound under cell-free conditions and co-immunoprecipitated from the lysates of the cells, where they were co-expressed; and USP15 deubiquitinated SLIM1, result...

journal_title：Biochemical and biophysical research communications

authors： Isumi Y,Hirata T,Saitoh H,Miyakawa T,Murakami K,Kudoh G,Doi H,Ishibashi K,Nakajima H

更新日期：2011-02-11 00:00:00

abstract：:Yeast cell viability and concentration are the crucial factors affecting product quality in food industry and bio-fuel production, as well as the evaluation basis for environmental toxic compounds. To overcome the drawbacks of existing methods, including high error, false positive and low automation, we propose a high...

journal_title：Biochemical and biophysical research communications

authors： Li G,Wei M,Sun J,Zhang Y,Zhang R

更新日期：2020-05-07 00:00:00

abstract：:A study was undertaken to examine the effects of the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, on pancreatic islet B cell differentiated function and number. Islets from 3-day-old rats were maintained in tissue culture for up to 30 days with or without the addition of the phorbol ester. Chan...

journal_title：Biochemical and biophysical research communications

authors： Schwizer RW

更新日期：1985-05-16 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) is a potent mutagen found in cooked food. MeIQx and its isotopically labelled (13C, 15N2 and 14C) analogues were synthesised and used for metabolic studies in vivo. An equimolar mixture of MeIQx and its 13C, 15N2 stable isotope labelled analogue (containing tracer ...

journal_title：Biochemical and biophysical research communications

authors： Gooderham NJ,Watson D,Rice JC,Murray S,Taylor GW,Davies DS

更新日期：1987-11-13 00:00:00

abstract：:We linked a 3.3 kb fragment containing the human gamma-globin gene together with a 5.5 kb fragment containing the human beta-globin gene. This construct was introduced into the germ line of mice. Analysis of the resulting transgenic mice showed that expression of the human gamma- and beta-globin genes were regulated a...

journal_title：Biochemical and biophysical research communications

authors： Katsube T,Tojo H,Sakaguchi T,Fukumaki Y

更新日期：1993-07-15 00:00:00

abstract：:Previous investigations in our laboratory demonstrated the existence of an intrinsic mechanism, termed membrane modulation, capable of restoring sensitivity to aspirin treated platelets, resulting in irreversible aggregation in response to arachidonic acid (AA). The mechanism underlying correction of aspirin induced i...

journal_title：Biochemical and biophysical research communications

authors： Rao GH,Radha E,White JG

更新日期：1985-08-30 00:00:00

abstract：:Planar bilayer studies are reported on the channel activity of des-L X Val7-D X Val8-Gramicidin A. This analog is designed to provide more long-lived side chain distributions involving the Trp residues than occur with Gramicidin A. The carbonyls of these residues coordinate the permeant cation and the energetics of th...

journal_title：Biochemical and biophysical research communications

authors： Urry DW,Alonso-Romanowski S,Venkatachalam CM,Harris RD,Prasad KU

更新日期：1984-02-14 00:00:00

abstract：:In mammalian cells, the Rab7 protein is a key element of late endocytic membrane traffic. Several results suggest that it is involved in the transport from early to late endosome or from late endosome to lysosome. We have previously characterized a Rab7 gene homologue (TcRAB7) in Trypanosoma cruzi. Now, using an affin...

journal_title：Biochemical and biophysical research communications

authors： Araripe JR,Cunha e Silva NL,Leal ST,de Souza W,Rondinelli E

更新日期：2004-08-20 00:00:00

abstract：:The present study investigates the immunomodulatory activities of buckwheat polysaccharide fraction (BPF) from the seed of Fagopyrum esculentum on RAW 264.7 macrophage cell line and Cyclophosphamide-induced immunosuppressed conditions in mice models. The results of in vitro showed that treatment with 0.5-10 μg/mL of B...

journal_title：Biochemical and biophysical research communications

authors： Oh MJ,Choi HD,Ha SK,Choi I,Park HY

更新日期：2018-02-19 00:00:00

abstract：:Our previous studies demonstrated that intravenous administration of staphylococcal enterotoxin B (SEB) to BALB/c mice resulted in thymocyte apoptosis. In the present study, we evaluated the role of protein kinase C (PKC) in thymocyte apoptosis induced by SEB. Our results showed that the level of protein phosphorylati...

journal_title：Biochemical and biophysical research communications

authors： Lin YS,Kao SF,Jan MS,Cheng ML,Wing LY,Chang WC,Lei HY,Lin MT

更新日期：1995-08-24 00:00:00

abstract：:Metallodaunomycin has been shown to cleave DNA only in the presence of oxygen, a reducing agent and a metal ion under reaction conditions similar to those used for the cuprous-phenanthroline complex. The intermediacy of 02-. and H2O2 has been substantiated by experiments with superoxide dismutase and catalase, respect...

journal_title：Biochemical and biophysical research communications

authors： Mariam YH,Glover GP

更新日期：1986-04-14 00:00:00

abstract：:In order to identify the mechanism by which cyclic AMP stimulates expression of the human renin gene (REN), the effect of forskolin was tested in transient expression analyses of REN 5'-flanking DNA-chloramphenicol acetyltransferase (CAT) reporter gene constructs in secondary cultures of human chorio-decidual cells, a...

journal_title：Biochemical and biophysical research communications

authors： Smith DL,Morris BJ,Do YS,Law RE,Shaw KJ,Hseuh WA

更新日期：1994-04-15 00:00:00

abstract：:Directed cell migration in tissues mediates various physiological processes and is guided by complex cellular factors such as chemoattractant gradients and electric fields. Direct current (DC) electric fields can be generated in physiological settings and the electric field guided migration of various cell types (i.e....

journal_title：Biochemical and biophysical research communications

authors： Wu D,Lin F

更新日期：2011-08-12 00:00:00

abstract：:Here we sought to evaluate the effect of palmitate on cytokine and PPAR activity/expression. We investigated the effect of BSA conjugated palmitate and oleate on PPAR activity, PPAR-α and δ expression, as well as the expression of cytokines and key factors responsible for β-oxidation by qRT-PCR and western blotting in...

journal_title：Biochemical and biophysical research communications

authors： Haffar T,Bérubé-Simard FA,Bousette N

更新日期：2015-03-27 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors belong to G protein-coupled transmembrane receptors (LPA receptors; LPA(1) to LPA(6)). They indicate a variety of cellular response by the interaction with LPA, including cell proliferation, migration and differentiation. Recently, we have reported that constitutive active mutated...

journal_title：Biochemical and biophysical research communications

authors： Kitayoshi M,Kato K,Tanabe E,Yoshikawa K,Fukui R,Fukushima N,Tsujiuchi T

更新日期：2012-06-01 00:00:00

abstract：:ER mRNA was detected as 6.0 kb band by Northern blot analysis in vascular smooth muscle cells (VSMC) derived from rat aorta. The presence of ER mRNA in VSMC was confirmed by reverse transcriptase-polymerase chain reaction using specific primers for rat ER cDNA. In addition, the immunocytochemistry of ER was performed ...

journal_title：Biochemical and biophysical research communications

authors： Orimo A,Inoue S,Ikegami A,Hosoi T,Akishita M,Ouchi Y,Muramatsu M,Orimo H

更新日期：1993-09-15 00:00:00

abstract：:Several chemokines, belonging to both the CXC and CC classes, act as positive or negative regulators of angiogenesis. We sought to investigate the role of CXCL13, B cell-attracting chemokine 1 (BCA-1), also known as B-lymphocyte chemoattractant (BLC), on endothelial cell functions. We tested the effect of CXCL13 on HU...

journal_title：Biochemical and biophysical research communications

authors： Spinetti G,Camarda G,Bernardini G,Romano Di Peppe S,Capogrossi MC,Napolitano M

更新日期：2001-11-23 00:00:00

abstract：:This study examines the influence of insoluble matrix components of glioma (astrocytoma) cells on LPS-mediated inducible nitric oxide (NO)/NO synthase (iNOS) induction in microglia cells. Insoluble matrix components prepared from C6 rat glioma cells strongly suppressed iNOS induction and subsequent NO release induced ...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Hwang SY,Han IO

更新日期：2006-09-01 00:00:00