The stimulation of prostaglandin production by transforming growth factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic.

abstract：:It has been suggested that the positive inotropic effect of the vasoactive peptide hormone, endothelin-1 (ET-1), involves inhibition of cardiac K(+) currents. In order to identify the K(+) currents modulated by ET-1, the outward K(+) currents of isolated rat ventricular myocytes were investigated using whole-cell patc...

journal_title：Biochemical and biophysical research communications

authors： James AF,Ramsey JE,Reynolds AM,Hendry BM,Shattock MJ

更新日期：2001-06-22 00:00:00

abstract：:The ATP-sensitive potassium channel of insulin-secreting pancreatic beta-cells is a complex of Kir6.2, a member of the inwardly rectifying potassium channel superfamily, and the sulfonylurea receptor. We have isolated cDNA clones encoding rat Kir6.2. Co-expression of rat Kir6.2 and sulfonylurea receptor in human embry...

journal_title：Biochemical and biophysical research communications

authors： Tokuyama Y,Fan Z,Furuta H,Makielski JC,Polonsky KS,Bell GI,Yano H

更新日期：1996-03-27 00:00:00

abstract：:The synthesis and in vitro biological activity of a hybrid protein composed of intact human chorionic gonadotropin and fragment A of diphtheria toxin in a disulfide conjugate is reported. This hybrid retained greater than 90% of the binding ability of uncoupled hCG and was shown to be specifically toxic to a mouse Ley...

journal_title：Biochemical and biophysical research communications

authors： Oeltmann TN

更新日期：1985-12-17 00:00:00

abstract：:During embryonic development of Musca domestica inactive ornithine decarboxylase protein appears in the embryos at 6 h postoviposition, increases in concentration and reaches a maximum level at 9 h postoviposition. The inactive enzyme is associated with the plasma membrane and appears to be the precursor for active or...

journal_title：Biochemical and biophysical research communications

authors： Lilleberg SL,Killilea SD,Vaske DA,Leopold RA,Sparks RB Jr

更新日期：1991-01-31 00:00:00

abstract：:Atmospheric oxygen is important for the epidermis, as the skin epidermis is not greatly affected by blood circulation. Therefore, it is necessary to understand the effect of hypoxic signals on the epidermis as some environmental stimuli can induce skin hypoxia. Here, we investigated how hypoxia (1% O2) affected skin e...

journal_title：Biochemical and biophysical research communications

authors： Park JY,Jung JY,Kim HJ,Bae IH,Kim DY,Lee TR,Shin DW

更新日期：2016-01-08 00:00:00

abstract：:Information about histone sequences and histone gene organization from invertebrate chordates is completely lacking. A genomic clone containing linked H3 and H4 histone genes from the urochordate Styela plicata was analyzed. The nucleotide sequence indicates that the two genes are transcribed in opposite directions an...

journal_title：Biochemical and biophysical research communications

authors： Ishaq AI,Rizvi SB,Wells DE,Tomlinson CR

更新日期：1993-07-30 00:00:00

abstract：:L-arginine may aid in the liver detoxification and may benefit in the treatment of liver disorders such as liver injury. The present study was to investigate the possible protective and curative effects of L-arginine on carbon tetrachloride (CCl(4)) induced hepatotoxicity. Mice received a single dose of CCl(4). L-argi...

journal_title：Biochemical and biophysical research communications

authors： Saad EA

更新日期：2012-06-22 00:00:00

abstract：:Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflam...

journal_title：Biochemical and biophysical research communications

authors： Chen WY,Chang YJ,Su CH,Tsai TH,Chen SD,Hsing CH,Yang JL

更新日期：2016-05-13 00:00:00

abstract：:Molecular chaperones prevent the aggregation of partially folded or misfolded forms of protein. alpha-crystallin performs such a function in the ocular lens. To gain insight into the mechanism of the anti-aggregation activity of alpha-crystallin, we performed dynamic light scattering (DLS) measurements investigating i...

journal_title：Biochemical and biophysical research communications

authors： Bettelheim FA,Ansari R,Cheng QF,Zigler JS Jr

更新日期：1999-08-02 00:00:00

abstract：:Sequences coding for the cytoplasmic and transmembrane domains were removed from the cDNA of the human Golgi resident membrane protein beta 1,4 galactosyltransferase (gal-T). The remaining sequences coding for the stem and catalytical domains of this glycosyltransferase were fused to sequences coding for the yeast inv...

journal_title：Biochemical and biophysical research communications

authors： Kleene R,Krezdorn CH,Watzele G,Meyhack B,Herrmann GF,Wandrey C,Berger EG

更新日期：1994-05-30 00:00:00

abstract：:The crystal structure of the mu and kappa opioid receptors has revealed dimeric structural arrangements. Mu-delta receptors heteromers also exist and we have identified discrete cytoplasmic regions in each receptor required for oligomer formation. In the carboxyl tail of the delta receptor we identified three glycine ...

journal_title：Biochemical and biophysical research communications

authors： O'Dowd BF,Ji X,O'Dowd PB,Nguyen T,George SR

更新日期：2012-06-15 00:00:00

abstract：:From a lambda UNI-ZAP XR cDNA library derived from poly(A)+RNA of human ovarian granulosa cells a cDNA clone pHG51 was isolated. Sequence analysis showed significant homology to the C-terminal region of rat ribosomal protein L8 cDNA. The 5'-end of the cDNA was completed by PCR with cloned total cDNA. Aligning of DNA s...

journal_title：Biochemical and biophysical research communications

authors： Hanes J,Klaudiny J,von der Kammer H,Scheit KH

更新日期：1993-12-30 00:00:00

abstract：:Interleukin-17 is a T-cell-derived pro-inflammatory cytokine, exhibiting multiple biological activities in a variety of cells and believed to fine tune all general phases of hematopoietic response. However, the signaling mechanism of this novel cytokine remains unknown. Here, we report for the first time that the earl...

journal_title：Biochemical and biophysical research communications

authors： Subramaniam SV,Cooper RS,Adunyah SE

更新日期：1999-08-19 00:00:00

abstract：:The helix-loop-helix protein Id-1 regulates growth and differentiation in many mammalian cells. In human fibroblasts, Id1 and Id1', a putative splicing variant, are cell cycle regulated, essential for proliferation, repressed by senescence, and overexpressed by some tumor cells. To better understand Id1, we determined...

journal_title：Biochemical and biophysical research communications

authors： Nehlin JO,Hara E,Kuo WL,Collins C,Campisi J

更新日期：1997-02-24 00:00:00

abstract：:Defects in neurogenesis and neuronal differentiation in the fetal brain of Down syndrome (DS) patients lead to the apparent neuropathological abnormalities and contribute to the phenotypic characters of mental retardation, and premature development of Alzheimer's disease, those being the most common phenotype in DS. I...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Kadota M,Nishigaki R,Kazuki Y,Shirayoshi Y,Rogers MS,Gojobori T,Ikeo K,Oshimura M

更新日期：2004-02-06 00:00:00

abstract：:This article investigated the effects of pramipexole on myocardial ischemia reperfusion (I/R) injury and its underlying mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in vitro H9c2 cell model of hypoxia/reoxygenation (H/R) injury. Pramipexole pretreatment in male C57BL/6 mice significan...

journal_title：Biochemical and biophysical research communications

authors： Mo Y,Tang L,Ma Y,Wu S

更新日期：2016-05-13 00:00:00

abstract：:JMJD2A-D belong to the JmjC domain-containing family of histone demethylases. JMJD2D is the most structurally divergent JMJD2 protein as it lacks the PHD and Tudor domains present in JMJD2A-C. Here, we systematically analyzed the histone demethylase specificity of JMJD2 proteins in vivo. We found that JMJD2A and C dem...

journal_title：Biochemical and biophysical research communications

authors： Shin S,Janknecht R

更新日期：2007-02-23 00:00:00

abstract：:The influence of various porphyrins (deuteroporphyrin IX, mesoporphyrin IX, protoporphyrin IX, hematoporphyrin) and two related compounds (hemin, biliverdin) on the spontaneous proliferation of mouse spleen lymphocytes has been estimated in vitro by the 3H-thymidine uptake assay. It has been found that porphyrins (end...

journal_title：Biochemical and biophysical research communications

authors： Stepien H,Kunert-Radek J,Stanisz A,Zerek-Melen G,Pawlikowski M

更新日期：1991-01-15 00:00:00

abstract：:We have previously demonstrated that homeodomain proteins, MEIS1 and PBXs, transactivate the PF4 gene through the novel regulatory element termed TME. This study focuses on Pbx regulating protein 1 (PREP1), a MEIS1 homolog protein, for its transcriptional activity in the PF4 promoter. PREP1 binds to the TME in HEL cel...

journal_title：Biochemical and biophysical research communications

authors： Okada Y,Matsuura E,Nagai R,Sato T,Watanabe A,Morita I,Doi T

更新日期：2003-05-23 00:00:00

abstract：:Nitric oxide (NO) produced by macrophages plays an important role in host defense and inflammation. We found that two agrochemicals, alachlor and carbaryl, inhibit lipopolysaccharide (LPS)-induced NO production by macrophages. In the present study, we investigated this inhibitory mechanism in RAW 264 cells. Both chemi...

journal_title：Biochemical and biophysical research communications

authors： Shimomura-Shimizu M,Sugiyama K,Muroi M,Tanamoto K

更新日期：2005-07-08 00:00:00

abstract：:It has been found that post-radiation mouse embryonic fibroblasts can well maintain the pluripotency in human embryonic stem cells. However, the molecular mechanism remains unclear. In the present study, the new protein expression profile of post-radiation mouse embryonic fibroblasts was analyzed by immobilized pH gra...

journal_title：Biochemical and biophysical research communications

authors： Xie CQ,Lin G,Luo KL,Luo SW,Lu GX

更新日期：2004-03-12 00:00:00

abstract：:Lactate dehydrogenase (LDH) is a glycolytic enzyme that catalyzes the final step of glycolysis and produces NAD+. In somatic cells, LDH forms homotetramers and heterotetramers that are encoded by two different genes: LDHA (skeletal muscle type, M) and LDHB (heart type, H). Analysis of LDH isozymes is important for und...

journal_title：Biochemical and biophysical research communications

authors： Goto T,Sugawara K,Nakamura S,Kidokoro SI,Wakui H,Nunomura W

更新日期：2016-10-28 00:00:00

abstract：:The precise assemblage of several types of cardiac precursors controls heart organogenesis. The cardiac precursors show dynamic movement during early development and then form the complicated heart structure. However, cardiomyocyte movements inside the newly organized mammalian heart remain unclear. We previously esta...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Yuasa S,Tabata H,Tohyama S,Seki T,Egashira T,Hayashiji N,Hattori F,Kusumoto D,Kunitomi A,Takei M,Kashimura S,Yozu G,Shimojima M,Motoda C,Muraoka N,Nakajima K,Sakaue-Sawano A,Miyawaki A,Fukuda K

更新日期：2015-09-04 00:00:00

abstract：:Temperature is one of the primary environmental factors that affect aging, in which protein phosphorylation is an important regulator. Currently, the understanding of phosphorylation events in regulatory networks during aging has remained rather limited. Herein, the phosphoproteomes of C.elegans of different age group...

journal_title：Biochemical and biophysical research communications

authors： Huang J,Wu Z,Wang J,Zhang X

更新日期：2018-09-10 00:00:00

abstract：:Gallbladder carcinoma (GBC), an aggressive and mostly lethal malignancy, is known to be resistant to a number of drug stimuli. Here, we demonstrated that arsenic trioxide inhibited the proliferation of gallbladder carcinoma in vivo and in vitro as well as the transcription of cell cycle-related protein Cyclin D1. And,...

journal_title：Biochemical and biophysical research communications

authors： Ai Z,Lu W,Ton S,Liu H,Sou T,Shen Z,Qin X

更新日期：2007-08-31 00:00:00

abstract：:Leber hereditary optic neuropathy (LHON) was the first disease to be linked to the presence of a mitochondrial DNA (mtDNA) mutation. Nowadays over 95% of LHON cases are known to be caused by one of three primary mutations (m.11778G>A, m.14484T>C, and m.3460G>A). Reports for other (rare) primary mutations in LHON patie...

journal_title：Biochemical and biophysical research communications

authors： Zhang AM,Zou Y,Guo X,Jia X,Zhang Q,Yao YG

更新日期：2009-08-21 00:00:00

abstract：:A prolyl isomerase Pin1 deficient (Pin1-/-) male mice had severe testicular atrophy. We investigated the function of Pin1 in spermatogenesis by analyzing the Pin1-/- mice at reproductive age. Pin1-/- mice had lessαPLZF positive spermatogonia (undifferentiated spermatogonia) than wild type (WT). Nevertheless, the Pin1-...

journal_title：Biochemical and biophysical research communications

authors： Kurita-Suzuki A,Kamo Y,Uchida C,Tanemura K,Hara K,Uchida T

更新日期：2018-02-26 00:00:00

abstract：:We report the modulatory effects of estrogen on release of endothelium-derived relaxing factors (EDRFs) in a human endothelial cell line, EA.hy926. Using bioassay, we showed that EA.hy926 released EDRF including nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) measured by relaxation of pre-contr...

journal_title：Biochemical and biophysical research communications

authors： Rahimian R,Chan L,Goel A,Poburko D,van Breemen C

更新日期：2004-09-17 00:00:00

abstract：:The Wnt/β-catenin signaling pathway, also known as the canonical Wnt pathway, plays a role in cell proliferation and differentiation in several tissues/organs. It has been recently described in humans a relationship between type 2 diabetes (T2DM) and mutation in the gene encoding the transcription factor TCF7L2 associ...

journal_title：Biochemical and biophysical research communications

authors： Maschio DA,Oliveira RB,Santos MR,Carvalho CP,Barbosa-Sampaio HC,Collares-Buzato CB

更新日期：2016-09-30 00:00:00

abstract：:The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcr...

journal_title：Biochemical and biophysical research communications

authors： Rockel B,Schmaler T,Huang X,Dubiel W

更新日期：2014-07-25 00:00:00