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PREP1, MEIS1 homolog protein, regulates PF4 gene expression.

Abstract：

:We have previously demonstrated that homeodomain proteins, MEIS1 and PBXs, transactivate the PF4 gene through the novel regulatory element termed TME. This study focuses on Pbx regulating protein 1 (PREP1), a MEIS1 homolog protein, for its transcriptional activity in the PF4 promoter. PREP1 binds to the TME in HEL cells. PREP1 was expressed in human megakaryocytes that differentiated from CD34(+) cells. EMSA shows that either PREP1 by itself or PREP1/PBX complexes bind to the two TGACAG motifs in the TME and activate the PF4 promoter. Furthermore, PREP1 and PREP1/PBX complexes synergistically activate the PF4 promoter with GATA-1 and ETS-1. These data demonstrate that PREP1 is also an important transcription factor that regulates PF4 gene expression such as MEIS1. Additionally, these data imply functional similarities and differences between PREP1 and MEIS1 in the regulation of PF4 gene expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Okada Y,Matsuura E,Nagai R,Sato T,Watanabe A,Morita I,Doi T

doi

10.1016/s0006-291x(03)00718-6

subject

Has Abstract

pub_date

2003-05-23 00:00:00

pages

155-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X03007186

journal_volume

305

pub_type

杂志文章

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