Pramipexole pretreatment attenuates myocardial ischemia/reperfusion injury through upregulation of autophagy.

Abstract:

:This article investigated the effects of pramipexole on myocardial ischemia reperfusion (I/R) injury and its underlying mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in vitro H9c2 cell model of hypoxia/reoxygenation (H/R) injury. Pramipexole pretreatment in male C57BL/6 mice significantly reduced the myocardial infarction size, decreased the CK and LDH activities at the serum level and enhanced autophagy. In the in vitro study, the pramipexole treatment significantly elevated the survival rate, decreased the LDH activity, reduced ROS generation and restored the ΔΨm in H9C2 cells during H/R. Additionally, its use could increase the autophagy flux level in H9c2 cells. The underlying mechanisms were determined by measuring the expression of the autophagic protein levels. These results further indicated that pramipexole treatment modulated H/R-induced autophagy via an AMPK-dependent pathway. All of these data indicate that pramipexole exerted protective effects against myocardial I/R injury and enhanced autophagy in part through the AMPK-mediated pathway.

authors

Mo Y,Tang L,Ma Y,Wu S

doi

10.1016/j.bbrc.2016.04.026

subject

Has Abstract

pub_date

2016-05-13 00:00:00

pages

1119-1124

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)30521-6

journal_volume

473

pub_type

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