Inhibitory effect of porphyrins on the proliferation of mouse spleen lymphocytes in vitro.

abstract：:Replacement of leucine in the chemotactic peptide For-Met-Leu-Phe by the sterically constrained amino acids alpha-aminoisobutyric acid and aminocyclohexanecarboxylic acid affords compounds of equal or greater activity than the parent. NMR studies indicate that the parent compound is present as a beta-sheet in solution...

journal_title：Biochemical and biophysical research communications

authors： Semus SF,Becker EL,Toniolo C,Freer RJ

更新日期：1988-12-15 00:00:00

abstract：:Escherichia coli H+-ATPase (ECF1) was inactivated in a time- and concentration-dependent manner by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), a selective carboxyl group reagent. Among the subunits of ECF1, only the beta subunit was modified by EEDQ. The reaction of 1 mol of EEDQ per mol of ECF1 resulted in...

journal_title：Biochemical and biophysical research communications

authors： Satre M,Dupuis A,Bof M,Vignais PV

更新日期：1983-07-29 00:00:00

abstract：:Northern hybridization studies showed that the level of ovalbumin mRNA decreases in the oviduct of the Japanese quail after adulthood. In order to find out if this is due to changes in the conformation of the chromatin containing the promoter region of the gene, nuclei of the oviduct of young, adult and old birds were...

journal_title：Biochemical and biophysical research communications

authors： Upadhyay R,Gupta S,Kanungo MS

更新日期：1996-09-13 00:00:00

abstract：:Expression of the MHC class I chain related molecules A and B (MICA/B) on tumor cell surface can signal the immune receptor NKG2D for tumor immune destruction. However, MIC was found to be shed by tumors in cancer patients, which negatively regulates host immunity and promotes tumor immune evasion and progression. The...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Lundgren AD,Singh P,Goodlett DR,Plymate SR,Wu JD

更新日期：2009-09-25 00:00:00

abstract：:Pierisin-2 is a cytotoxic and apoptosis-inducing protein present in Pieris brassicae with a 91% homology in the deduced amino acid sequences to pierisin-1 from Pieris rapae. We earlier showed pierisin-1 to catalyze mono(ADP-ribosyl)ation of 2'-deoxyguanosine (dG) in DNA to form N2-(ADP-ribos-1-yl)-2'-deoxyguanosine, t...

journal_title：Biochemical and biophysical research communications

authors： Takamura-Enya T,Watanabe M,Koyama K,Sugimura T,Wakabayashi K

更新日期：2004-10-15 00:00:00

abstract：:Hepatic fibrosis can be considered as wound healing process in response to hepatocellular injury. Activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis since activated HSCs are the cellular source of enhanced extracellular matrix deposition, and reversion of liver fibrosis is accompanied by cl...

journal_title：Biochemical and biophysical research communications

authors： Valletta D,Czech B,Thasler WE,Müller M,Bosserhoff AK,Hellerbrand C

更新日期：2012-09-28 00:00:00

abstract：:The involvement of vitamin D in prostate carcinogenesis was investigated using the human prostatic LNCaP cells. Incubation of the LNCaP with 100 nM 1 alpha,25-dihydroxyvitamin D3 for 2 days resulted in a 30-40% suppression of cell growth, which was accompanied by a greater than 70% down-regulated expression of the pro...

journal_title：Biochemical and biophysical research communications

authors： Hsieh TY,Ng CY,Mallouh C,Tazaki H,Wu JM

更新日期：1996-06-05 00:00:00

abstract：:Renal homeostasis is regulated by the interplay among different cell types in the kidneys including endothelial cells. In the present study we investigated the phenotypic regulation of endothelial cells by BRG1, a chromatin remodeling protein, in a mouse model of obstructive nephropathy (ON). We report that endothelia...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Mao L,Xu Y,Wu X

更新日期：2019-09-17 00:00:00

abstract：:Polyclonal antibodies (pAbs) to riboflavin carrier protein (RCP) purified from human amniotic fluid were raised in two rabbits. These pAbs apart from recognizing the parent antigen, reacted significantly with chicken RCP as well. When all the 212 octapeptides overlapping by one amino acid residue and covering the enti...

journal_title：Biochemical and biophysical research communications

authors： Subramanian S,Adiga PR

更新日期：1999-08-27 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is involved in DNA repair and activated by DNA damage. When activated, PARP-1 consumes NAD(+) to form ADP-ribose polymers on acceptor proteins. Extensive activation of PARP-1 leads to glycolytic blockade, energy failure, and cell death. These events have ...

journal_title：Biochemical and biophysical research communications

authors： Ying W,Garnier P,Swanson RA

更新日期：2003-09-05 00:00:00

abstract：:The murine C-5 cytosine DNA methyltransferase (MTase, E.C.2.1.1.37) containing a hexahistidine affinity leader peptide has been expressed at levels which are at least 50-fold higher than previously reported. The recombinant enzyme has activity levels similar to the wild-type enzyme. The recombinant polypeptide binds t...

journal_title：Biochemical and biophysical research communications

authors： Glickman JF,Reich NO

更新日期：1994-11-15 00:00:00

abstract：:A P1 phage clone containing the near complete protein coding region of the human histo-blood group ABO gene locus was isolated and characterized. The insert was estimated at approximately 41 kp, and an approximately 20 kbp BamHI fragment contained the near complete coding region as evaluated by Southern blot analysis....

journal_title：Biochemical and biophysical research communications

authors： Bennett EP,Steffensen R,Clausen H,Weghuis DO,van Kessel AG

更新日期：1995-01-05 00:00:00

abstract：:Mutations in the human TCOF1 gene have been identified in patients with Treacher Collins Syndrome (Mandibulofacial Dysostosis), an autosomal dominant condition affecting the craniofacial region. We report the isolation of the entire mouse Tcof1 coding sequence (3960 bp) by performing a computer-based search for mouse ...

journal_title：Biochemical and biophysical research communications

authors： Paznekas WA,Zhang N,Gridley T,Jabs EW

更新日期：1997-09-08 00:00:00

abstract：:Human hepatocarcinoma Hep G2 cells were grown in culture medium containing [45Ca2+]. The secreted lipoproteins of d less than 1.063 g/ml and d 1.063-1.21 g/ml were isolated from the culture media and analyzed by 3.3% and 7% SDS-polyacrylamide gel electrophoresis. Radioactivity profiles of [45Ca] from the gels showed t...

journal_title：Biochemical and biophysical research communications

authors： Dashti N,Lee DM,Mok T

更新日期：1986-05-29 00:00:00

abstract：:Using red cells as an experimental model, we previously showed that a limited degradation of certain membrane proteins by calpain (Ca2+-activated thiol protease) was a necessary prerequisite for cell fusion and that fusibility depended on the ratio of calpain to its endogenous inhibitor calpastatin. Here we show that ...

journal_title：Biochemical and biophysical research communications

authors： Barnoy S,Glasner T,Kosower NS

更新日期：1996-03-27 00:00:00

abstract：:Acrosomal protease activation is regarded as an important event triggered by acrosomal reaction and leading to sperm passage through zona pellucida. Mammalian acrosome has an internal acid pH that probably helps to maintain inactive proenzymes that otherwise could be precociously activated and prevent normal fertiliza...

journal_title：Biochemical and biophysical research communications

authors： Codelia VA,Cortes CJ,Moreno RD

更新日期：2005-12-02 00:00:00

abstract：:Tumor necrosis factor (TNF)alpha is considered to play a key pathogenetic role in inflammatory bowel diseases. In this study we analyzed the mechanisms by which TNFalpha induces intestinal epithelial cell apoptosis. TNFalpha alone, and more potently in combination with IFNgamma, induced a high degree of IEC-6 cell apo...

journal_title：Biochemical and biophysical research communications

authors： Ruemmele FM,Dionne S,Levy E,Seidman EG

更新日期：1999-06-24 00:00:00

abstract：:Filamin increases and tropomyosin decreases the susceptibility of F-actin to form bundles of filaments in the presence of polyethylene glycol 6000. The two proteins, which are located in the leading edge and in the internal part of the cell, respectively, are thus likely to display divergent effects on the microfilame...

journal_title：Biochemical and biophysical research communications

authors： Grazi E,Trombetta G,Guidoboni M

更新日期：1990-03-30 00:00:00

abstract：:Most of the ADP-glucose pyrophosphorylases from different sources are stable to a heat treatment. We found that in the potato (Solanum tuberosum L.) tuber enzyme, the intermolecular disulfide bridge located between Cys12 of the small subunits is responsible for the stability at 60 degrees C. When this unique disulfide...

journal_title：Biochemical and biophysical research communications

authors： Ballicora MA,Fu Y,Frueauf JB,Preiss J

更新日期：1999-04-21 00:00:00

abstract：:The existence of cancer stem cells within the tumor could lead to cancer therapy resistance. TGFβ1 is considered as one of the most powerful players in the generation of CSCs through induction of epithelial-mesenchymal transition in different types of cancer including lung cancer, however, the detailed mechanisms by w...

journal_title：Biochemical and biophysical research communications

authors： Zhang F,Li T,Han L,Qin P,Wu Z,Xu B,Gao Q,Song Y

更新日期：2018-02-19 00:00:00

abstract：:Autophagy is a biological recycling process via the self-digestion of organelles, proteins, and lipids for energy-consuming differentiation and homeostasis. The Golgi serves as a donor of the double-membraned phagophore for autophagosome assembly. In addition, recent studies have demonstrated that pulmonary and hepati...

journal_title：Biochemical and biophysical research communications

authors： Park S,Kim S,Kim MJ,Hong Y,Lee AY,Lee H,Tran Q,Kim M,Cho H,Park J,Kim KP,Park J,Cho MH

更新日期：2018-01-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) produced by hepatocellular carcinoma (HCC) cells are responsible for the growth of HCC cells. Accumulating evidence shows that insulin-like growth factor-binding protein-3 (IGFBP-3) suppresses HCC cell proliferation in both IGF-dependent a...

journal_title：Biochemical and biophysical research communications

authors： Ma Y,Han CC,Li Y,Wang Y,Wei W

更新日期：2016-09-16 00:00:00

abstract：:Tissue transglutaminase (TGase 2) has been reported to have multiple functions in addition to its function as a biological adhesive. To identify its roles, we investigated the effects of TGase 2 on gelatinase activity. The MMP-9 activity of certain cell lines was significantly inhibited with retinoic acid treatment, a...

journal_title：Biochemical and biophysical research communications

authors： Ahn JS,Kim MK,Hahn JH,Park JH,Park KH,Cho BR,Park SB,Kim DJ

更新日期：2008-11-28 00:00:00

abstract：:Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes in breast cancer and other solid tumors, however the identity and roles of many of the soluble factors these macrophages produce remains to be elucidated in detail. In addition to producing angiogenic factors (e.g. VEGF), protea...

journal_title：Biochemical and biophysical research communications

authors： Levano KS,Jung EH,Kenny PA

更新日期：2011-07-22 00:00:00

abstract：:The addition of the tumor-promoting phorbol 12-myristate, 13-acetate to rabbit neutrophils greatly potentiates the effect of the calcium ionophore A23187 on [3H]-arachidonic acid release and [32P]-phosphatidic acid generation. At 5 X 10(-8) M A23187, the addition of 20 ng/ml PMA potentiates the action of the ionophore...

journal_title：Biochemical and biophysical research communications

authors： Volpi M,Molski TF,Naccache PH,Feinstein MB,Sha'afi RI

更新日期：1985-04-30 00:00:00

abstract：:To maintain immune homeostasis in the intestine, the intestinal immune system has evolved several tolerogenic mechanisms toward intestinal microflora and food antigens. Although programmed cell death-1 (PD-1) protein has been implicated in immunological tolerance in the intestine and gut-associated lymphoid tissues (G...

journal_title：Biochemical and biophysical research communications

authors： Doi T,Kanai T,Mikami Y,Sujino T,Jun L,Ono Y,Hayashi A,Hibi T

更新日期：2012-09-07 00:00:00

abstract：:A simple in situ model of alamethicin-permeabilized isolated rat liver mitochondria was used to investigate the channeling of NADH between mitochondrial malate dehydrogenase (MDH) and NADH:ubiquinone oxidoreductase (complex I). Alamethicin-induced pores in the mitochondrial inner membrane allow effective transport of ...

journal_title：Biochemical and biophysical research communications

authors： Kotlyar AB,Maklashina E,Cecchini G

更新日期：2004-06-11 00:00:00

abstract：:CAD/DFF40, the nuclease responsible for DNA fragmentation during apoptosis, exists as a heterodimeric complex with DFF45/ICAD. This study determines the molecular mechanisms of regulation of DFF40 via the chaperone and inhibition activities of DFF45. We analyze proteins corresponding to the fragments (D1, D2, and D3) ...

journal_title：Biochemical and biophysical research communications

authors： McCarty JS,Toh SY,Li P

更新日期：1999-10-14 00:00:00

abstract：:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Suzuki N

更新日期：2014-10-03 00:00:00

abstract：:The smallest protein of hepatitis B virus, HBX, has been implicated in the development of liver diseases by interfering with normal cellular processes. Its role in cell proliferation has been unclear as both pro-apoptotic and anti-apoptotic activities have been reported. We showed molecular evidence that HBX induced a...

journal_title：Biochemical and biophysical research communications

authors： Lu YW,Chen WN

更新日期：2005-12-23 00:00:00