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Tissue transglutaminase-induced down-regulation of matrix metalloproteinase-9.

Abstract：

:Tissue transglutaminase (TGase 2) has been reported to have multiple functions in addition to its function as a biological adhesive. To identify its roles, we investigated the effects of TGase 2 on gelatinase activity. The MMP-9 activity of certain cell lines was significantly inhibited with retinoic acid treatment, and this effect was reversed in the presence of a TGase 2 inhibitor. Furthermore, TGase 2 overexpression reduced the MMP-9 protein expression levels and inhibited its activity in both culture media and cell lysate. The decreased mRNA levels of MMP-9 and the results of a promoter assay revealed that TGase 2 may be involved in MMP-9 transcription. Further, data obtained in an immunoprecipitation assay and an electrophoretic mobility shift assay demonstrated that TGase 2 binds to c-Jun and suppresses its binding activity toward AP-1. These results suggest that TGase 2 inhibits MMP-9 via downregulation of MMP-9 transcription activity by blocking the binding of the Jun-fos complex to an AP-1 site.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ahn JS,Kim MK,Hahn JH,Park JH,Park KH,Cho BR,Park SB,Kim DJ

doi

10.1016/j.bbrc.2008.09.048

subject

Has Abstract

pub_date

2008-11-28 00:00:00

pages

743-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01825-1

journal_volume

376

pub_type

杂志文章

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