Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity.

abstract：:SHPS-1 (SHP substrate-1) is a glycosylated receptor-like protein with three immunoglobulin-like domains in its extracellular region and four YXX(L/V/I) motifs, potential tyrosine phosphorylation and SRC homology 2 (SH2) domain binding sites, in its cytoplasmic region. Various mitogens and cell adhesion induce tyrosine...

journal_title：Biochemical and biophysical research communications

authors： Yamao T,Matozaki T,Amano K,Matsuda Y,Takahashi N,Ochi F,Fujioka Y,Kasuga M

更新日期：1997-02-03 00:00:00

abstract：:Transcription factors belonging to the CCAAT-enhancer binding protein (C/EBP) family have been implicated in the regulation of gene expression during growth, differentiation, apoptosis, and inflammation. Autoregulation is relatively common in the modulation of C/EBP gene expression and, for the human and murine C/EBPa...

journal_title：Biochemical and biophysical research communications

authors： Davies GE,Sabatakos G,Cryer A,Ramji DP

更新日期：2000-05-10 00:00:00

abstract：:Dexamethasone (DEX), a glucocorticoid which induces cleft palate, causes marked alterations in the synthesis and degradation of phosphatidylinositol (PI) but not phosphatidylcholine in an established fibroblastic cell line derived from a human embryonic palate. Incorporation of radiolabeled inositol into phosphatidyli...

journal_title：Biochemical and biophysical research communications

authors： Grove RI,Willis WD,Pratt RM

更新日期：1983-01-14 00:00:00

abstract：:Heterogeneity in transmissible spongiform encephalopathy is thought to have derived from conformational variation in an abnormal isoform of the prion protein (PrPSc). To characterize PrPSc in bovine spongiform encephalopathy (BSE) and scrapie, we analyzed the newly generated N-terminus of PrPSc isoforms by digestion w...

journal_title：Biochemical and biophysical research communications

authors： Hayashi HK,Yokoyama T,Takata M,Iwamaru Y,Imamura M,Ushiki YK,Shinagawa M

更新日期：2005-03-25 00:00:00

abstract：:Non-lethal hyperthermia is used clinically as adjuvant treatment to radiation, with mixed results. Denaturation of protein during hyperthermia treatment is expected to synergize with radiation damage to cause cell cycle arrest and apoptosis. Alternatively, hyperthermia is known to cause tissue level changes in blood f...

journal_title：Biochemical and biophysical research communications

authors： Kim YS,Lee TH,O'Neill BE

更新日期：2015-08-14 00:00:00

abstract：:Phospholipase D has been implicated as an important enzyme in a range of cellular responses, including regulated secretion and the formation of secretory vesicles, cell proliferation and control of cell morphology. As insulin treatment of adipocytes has been shown to stimulate a phosphatidylcholine-specific phospholip...

journal_title：Biochemical and biophysical research communications

authors： Millar CA,Jess TJ,Saqib KM,Wakelam MJ,Gould GW

更新日期：1999-01-27 00:00:00

abstract：:Modulation of autophagy is a new paradigm in cancer therapeutics. Recently a novel function of chloroquine (CLQ) in inhibiting degradation of autophagic vesicles has been revealed, which raises the question whether CLQ can be used as an adjuvant in targeting autophagic pro-survival mechanism in prostate cancer (PCa). ...

journal_title：Biochemical and biophysical research communications

authors： Kaini RR,Hu CA

更新日期：2012-08-24 00:00:00

abstract：:Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ...

journal_title：Biochemical and biophysical research communications

authors： Wictome M,Holub M,East JM,Lee AG

更新日期：1994-03-15 00:00:00

abstract：:The 3(')-->5(')-exonucleolytic activity of human apurinic/apyrimidinic endonuclease 1 (APE1) on mispaired DNA at the 3(')-termini of recessed, nicked or gapped DNA molecules was analyzed and compared with the primary endonucleolytic activity. We found that under reaction conditions optimal for AP endonuclease activity...

journal_title：Biochemical and biophysical research communications

authors： Lebedeva NA,Khodyreva SN,Favre A,Lavrik OI

更新日期：2003-01-03 00:00:00

abstract：:Oxidosqualene:protostadienol cyclase (OSPC) from the fungus Aspergillus fumigatus, catalyzes the cyclization of (3S)-2,3-oxidosqualene into protosta-17(20)Z,24-dien-3beta-ol which is the precursor of the steroidal antibiotic helvolic acid. To shed light on the structure-function relationship between OSPC and oxidosqua...

journal_title：Biochemical and biophysical research communications

authors： Kimura M,Kushiro T,Shibuya M,Ebizuka Y,Abe I

更新日期：2010-01-01 00:00:00

abstract：:Baculovirus p35 belongs to the early class of genes of AcMNPV and requires viral factors like Immediate Early protein-1 for its transcription. To investigate the role of host factors in regulating p35 gene expression, the putative transcription factor binding sites were examined in silico and the role of these factors...

journal_title：Biochemical and biophysical research communications

authors： Mohareer K,Sahdev S,Hasnain SE

更新日期：2011-11-04 00:00:00

abstract：:Erythroid progenitor cells synthesize 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) when stimulated by erythropoietin (Ep). Maximal stimulation of 12-HETE production occurred at one hour, whereas 15-HETE activity remained constant in response to Ep for 24 hours. Lipoxygenase-s...

journal_title：Biochemical and biophysical research communications

authors： Beckman BS,Mason-Garcia M,Nystuen L,King L,Fisher JW

更新日期：1987-08-31 00:00:00

abstract：:Human Cla-1 is the likely homologue of the murine scavenger receptor class B type I (SR-BI). SR-BI mediates selective transfer of cholesterol to high-density lipoprotein (HDL) and the efflux of endogenously synthesized and plasma membrane sterols to HDL. HDL protects against atherosclerosis but also reduces endotoxic ...

journal_title：Biochemical and biophysical research communications

authors： Buechler C,Ritter M,Quoc CD,Agildere A,Schmitz G

更新日期：1999-08-19 00:00:00

abstract：:Secreted by tumor and stromal cells, S100 proteins exert their biological functions via the interaction with surface receptors. The most described receptor is the receptor for advanced glycation end-products (RAGE), thereby participating in the S100-dependent cell migration, invasion, tumor growth, angiogenesis and me...

journal_title：Biochemical and biophysical research communications

authors： Padilla L,Dakhel S,Hernández JL

更新日期：2014-03-28 00:00:00

abstract：:We report the cloning and characterization of both the cDNA (tufA) and genomic clones encoding for a chloroplast translation elongation factor (EF-Tu) from pea. The analysis of the deduced amino acids of the cDNA clone reveals the presence of putative transit peptide sequence and four GTP binding domains and two EF-Tu...

journal_title：Biochemical and biophysical research communications

authors： Singh BN,Mishra RN,Agarwal PK,Goswami M,Nair S,Sopory SK,Reddy MK

更新日期：2004-07-23 00:00:00

abstract：:To identify novel roles of SMALL RUBBER PARTICLE PROTEIN Homolog in the non-rubber-producing plant Arabidopsis (AtSRP1), we isolated a T-DNA-insertion knock-out mutant (FLAG_543A05) and investigated its functional characteristics. AtSRP1 is predominantly expressed in reproductive organs and is localized to lipid dropl...

journal_title：Biochemical and biophysical research communications

authors： Chi YH,Kim SY,Lee ES,Jung YJ,Park JH,Paeng SK,Oh HT,Melencion SM,Alinapon CV,Lee SY

更新日期：2016-06-24 00:00:00

abstract：:We have obtained two new mAbs to the carboxy-terminal region of fibronectin, namely P3D4 and P1F11, and have studied their binding sites and their ability to block lymphocyte adhesion to fibronectin. ELISA and Western blot analyses showed that P3D4 reacts with both fibronectin chains and both Hep II-containing fragmen...

journal_title：Biochemical and biophysical research communications

authors： Garcia-Pardo A,Sánchez-Aparicio P,Wayner EA

更新日期：1992-07-15 00:00:00

abstract：:We report the isolation of a gene encoding a novel member of the family of melanocortin receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an increase in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) concentrations. Stimulation of the mMC5R by the melanocortins revealed a h...

journal_title：Biochemical and biophysical research communications

authors： Gantz I,Shimoto Y,Konda Y,Miwa H,Dickinson CJ,Yamada T

更新日期：1994-05-16 00:00:00

abstract：:The causative agent of Lyme disease, Borrelia burgdorferi, requires shifts in gene expression to undergo its natural enzootic cycle between tick and vertebrate hosts. mRNA decay mechanisms play significant roles in governing gene expression in other bacteria, but are not yet characterized in B. burgdorferi. RNase III ...

journal_title：Biochemical and biophysical research communications

authors： Snow S,Bacon E,Bergeron J,Katzman D,Wilhelm A,Lewis O,Syangtan D,Calkins A,Archambault L,Anacker ML,Schlax PJ

更新日期：2020-08-20 00:00:00

abstract：:CHFR ubiquitin ligase acts as a checkpoint upon DNA damage and its functional inactivation is one of key characteristics of tumor development and metastasis. Despite the crucial role in maintaining genome integrity and cell cycle progression, little is known how CHFR stability is regulated. Here, we showed that CHFR i...

journal_title：Biochemical and biophysical research communications

authors： Kwon YE,Bae SJ,Kim M,Seol JH

更新日期：2013-01-04 00:00:00

abstract：:A hitherto unknown synergism exerted by retinol (vitamin A) and L-ascorbic acid (vitamin C) was discovered using endothelial cells. Retinol stimulated the extracellular and intracellular activities of plasminogen activator up to approximately 8- and 4-fold from the control values, respectively. L-Ascorbic acid enhance...

journal_title：Biochemical and biophysical research communications

authors： Inada Y,Hagiwara H,Kojima S,Shimonaka M,Saito Y

更新日期：1985-07-16 00:00:00

abstract：:C57BL/6 mice were orally infected with different doses of cysts of ME49 strain of Toxoplasma gondii to produce groups of acutely and chronically infected mice. Sera were obtained at different periods post-infection. SDS-PAGE was ran with excretory/secretory antigens of ME49 and RH strains of T. gondii, followed by Wes...

journal_title：Biochemical and biophysical research communications

authors： Rahmah N,Anuar AK

更新日期：1992-08-31 00:00:00

abstract：:We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet p...

journal_title：Biochemical and biophysical research communications

authors： Noda S,Mashima Y,Obazawa M,Kubota R,Oguchi Y,Kudoh J,Minoshima S,Shimizu N

更新日期：2000-10-05 00:00:00

abstract：:Photoinactivation is a common phenomenon in bioluminescence ctenophore photoproteins (e.g mnemiopsin, berovin and BfosPP) with still unknown mechanism. The activity of coelenterate photoproteins (e.g aequorin), which has high structural similarity with ctenophore photoproteins, is not affected by light. Recently, we h...

journal_title：Biochemical and biophysical research communications

authors： Pashandi Z,Molakarimi M,Mohseni A,Sajedi RH,Taghdir M,Naderi-Manesh H

更新日期：2017-08-19 00:00:00

abstract：:Novel conformation-specific antibodies were raised against a cyclic chimeric dodecapeptidyl multiple antigen peptide (cCD-MAP) constructed with a spacer-armed Gly-Asp dipeptide and two pentapeptides (S(169)-Q(170)-K(171)-E(172)-G(173) of CCR5 and E(179)-A(180)-D(181)-D(182)-R(183) of CXCR4) which are components of the...

journal_title：Biochemical and biophysical research communications

authors： Misumi S,Takamune N,Ido Y,Hayashi S,Endo M,Mukai R,Tachibana K,Umeda M,Shoji S

更新日期：2001-08-03 00:00:00

abstract：:Signaling via the type 1 insulin-like growth factor receptor (IGF1R) confers resistance to EGF receptor (EGFR) inhibitors. It is plausible that reciprocal EGFR compensation could mediate resistance to IGF1R inhibition, prompting us to investigate effects of IGF1R depletion on EGFR signaling in breast cancer cells expr...

journal_title：Biochemical and biophysical research communications

authors： Riedemann J,Sohail M,Macaulay VM

更新日期：2007-04-13 00:00:00

abstract：:In most animal species and many prokaryotes, methylmalonyl CoA mutase catalyzes isomerization between methylmalonyl CoA and succinyl CoA using adenosylcobalamin as a cofactor. We describe the absence of this enzyme in Aspergillus nidulans based on the absence of enzyme activity in vitro and the failure to metabolize m...

journal_title：Biochemical and biophysical research communications

authors： Ledley FD,Crane AM,Klish KT,May GS

更新日期：1991-06-28 00:00:00

abstract：:Ceramide kinase (CERK) and its product, ceramide-1-phosphate (Cer-1-P), are implicated in signaling processes, but the action mechanisms are not fully elucidated. When checking for intracellular effects of Cer-1-P by exposing CERK-expressing CHO cells to truncated ceramides, an unexpected decrease in CERK activity and...

journal_title：Biochemical and biophysical research communications

authors： Van Overloop H,Van Veldhoven PP

更新日期：2007-12-07 00:00:00

abstract：:Genetic predisposition is necessary for polycystic kidney disease (PKD) initiation, although there are other, incompletely identified downstream processes that are required for cyst growth. Their characterization may provide a unique opportunity for clinical interventions. One of the poorly studied phenomena in PKD is...

journal_title：Biochemical and biophysical research communications

authors： Arkhipov SN,Pavlov TS

更新日期：2019-05-21 00:00:00

abstract：:Autophagy is a mechanism to digest cells' own components, and its importance in many physiological and pathological processes is being recognized. But the molecular mechanism that regulates autophagy is not understood in detail. In the present study, we found that cholesterol depletion induces macroautophagy. The cell...

journal_title：Biochemical and biophysical research communications

authors： Cheng J,Ohsaki Y,Tauchi-Sato K,Fujita A,Fujimoto T

更新日期：2006-12-08 00:00:00