Is there methylmalonyl CoA mutase in Aspergillus nidulans?

Abstract:

:In most animal species and many prokaryotes, methylmalonyl CoA mutase catalyzes isomerization between methylmalonyl CoA and succinyl CoA using adenosylcobalamin as a cofactor. We describe the absence of this enzyme in Aspergillus nidulans based on the absence of enzyme activity in vitro and the failure to metabolize methylmalonate or grow in media containing this organic acid as the sole carbon source. These data contrast previous assumptions that propionate may be metabolized through propionyl CoA and methylmalonyl CoA to the TCA cycle in this organism. This is consistent with the separate evolution of these pathways in animals and lower eukaryotes due to the distinct endosymbiotic origin of their mitochondria.

authors

Ledley FD,Crane AM,Klish KT,May GS

doi

10.1016/0006-291x(91)90648-q

subject

Has Abstract

pub_date

1991-06-28 00:00:00

pages

1076-81

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90648-Q

journal_volume

177

pub_type

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