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The same nuclear proteins bind the proximal CACCC box of the human beta-globin promoter and a similar sequence in the enhancer.

Abstract：

:Using in vitro assays, we show that nuclear proteins related to the Sp1 and GT-1 factors bind to a CACCC box sequence in the human beta-globin enhancer, adjacent to binding sites for the erythroid-specific factor NFE1 and the ubiquitous factor CP1. The same proteins are known to bind to the proximal, but not to the distal, CACCC, box in the human beta-globin promoter. A C G mutation in the promoter CACCC box, known to cause beta-thalassemia, greatly decreases protein binding to the CACCC box; the same effect is obtained when this mutation is introduced into the enhancer CACCC box.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Giglioni B,Comi P,Ronchi A,Mantovani R,Ottolenghi S

doi

10.1016/0006-291x(89)91695-1

subject

Has Abstract

pub_date

1989-10-16 00:00:00

pages

149-55

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91695-1

journal_volume

164

pub_type

杂志文章

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