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Beta-35 is a transferrin-derived inhibitor of angiogenesis and tumor growth.

Abstract：

:An angiogenesis inhibitor named Beta-35 has been identified and purified from the conditioned medium of mouse pancreatic β cells tumor cells. Beta-35 has a molecular weight of 35 kDa and inhibits DNA synthesis of bovine capillary endothelial cells at a half-maximal concentration of approximately 5 nM. It shows anti-angiogenic activity in the chick embryo chorioallantoic membrane at a dose of about 1 μg/embryo. Amino acid microsequencing and mass spectrometric analysis of the purified protein demonstrate that Beta-35 contains the first 314 residues of the N-terminal sequence of bovine transferrin. We have cloned and expressed this protein in Escherichia coli using the corresponding gene segment of Beta-35 contained in the cDNA of human transferrin. The recombinant protein of Beta-35 shows significant anti-tumor activity at a dose of 5mg/kg/day against human pancreatic cancer or melanoma implanted subcutaneously in SCID mice.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Liang G,Butterfield C,Liang J,Birsner A,Folkman J,Shing Y

doi

10.1016/j.bbrc.2011.05.045

subject

Has Abstract

pub_date

2011-06-10 00:00:00

pages

562-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)00805-9

journal_volume

409

pub_type

杂志文章

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