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An immunomodulatory protein, Ling Zhi-8, facilitates cellular interaction through modulation of adhesion molecules.

Abstract：

:Ling Zhi-8 (LZ-8), a novel immunomodulatory protein, markedly enhanced the expression of CD11b, but not CD11a, CD13, CD14, CD18, CD33 or HLA-DR, on the U937 cell line in a dose-dependent fashion. It also induced ICAM-1 expression on vascular endothelial cells and significantly augmented gamma - interferon-induced cellular binding between vascular endothelial cells and U937. Furthermore, LZ-8 increased the expression of CD2, but not VLA4, VLA5 or LFA3, on MOLT4 and enhanced rosette formation between human T cells and sheep red blood cells. These data suggest that LZ-8 exerts its pharmacological effect by modulating adhesion molecules on immunocompetent cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Miyasaka N,Inoue H,Totsuka T,Koike R,Kino K,Tsunoo H

doi

10.1016/s0006-291x(05)80819-8

subject

Has Abstract

pub_date

1992-07-15 00:00:00

pages

385-90

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)80819-8

journal_volume

186

pub_type

杂志文章

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