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Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death.

Abstract：

:In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action of this hormone during ischemia. Rat hearts were perfused ex vivo with an ischemia/reperfusion Langendorff model in absence or presence of insulin. Additionally, cultured rat cardiomyocytes were exposed to simulated ischemia in the absence or presence of insulin. Cytoprotective effects were measured by myocardial infarct size, trypan blue exclusion, released LDH and DNA fragmentation by flow cytometry. We found that insulin protected against cardiac ischemia ex vivo and in vitro. Moreover, insulin protected cardiomyocytes from simulated ischemia by reducing necrotic cell death. Protective effects of insulin were dependent of Akt and NFκB. These novel results show that insulin reduces ischemia-induced cardiomyocyte necrosis through an Akt/NF-κB dependent mechanism. These novel findings clarify the role of insulin during ischemia and further support its use in early GIK perfusion to treat myocardial infarction.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Díaz A,Humeres C,González V,Gómez MT,Montt N,Sanchez G,Chiong M,García L

doi

10.1016/j.bbrc.2015.09.171

subject

Has Abstract

pub_date

2015-11-13 00:00:00

pages

451-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)30697-5

journal_volume

467

pub_type

杂志文章

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