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A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7.

Abstract：

:Din7 is a DNA damage-inducible mitochondrial nuclease that modulates the stability of mitochondrial DNA (mtDNA) in Saccharomyces cerevisiae. How DIN7 gene expression is regulated, however, has remained largely unclear. Using promoter sequence alignment, we found a highly conserved 19-bp sequence in the promoter regions of DIN7 and NTG1, which encodes an oxidative stress-inducible base-excision-repair enzyme. Deletion of the 19-bp sequence markedly reduced the hydroxyurea (HU)-enhanced DIN7 promoter activity. In addition, nuclear fractions prepared from HU-treated cells were used in in vitro band shift assays to reveal the presence of currently unidentified trans-acting factor(s) that preferentially bound to the 19-bp region. These results suggest that the 19-bp sequence is a novel cis-acting element that is required for the regulation of DIN7 expression in response to HU-induced DNA damage.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yoshitani A,Yoshida M,Ling F

doi

10.1016/j.bbrc.2007.10.177

subject

Has Abstract

pub_date

2008-01-04 00:00:00

pages

183-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)02354-6

journal_volume

365

pub_type

杂志文章

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