Characterization of representative enzymes from a sulfate reducing bacterium implicated in the corrosion of steel.

abstract：:To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice. In this model, distinct tumor growth was observed around 6 days after inoculation. Daily administration of cimetidine (0.12 mg/kg/day) significa...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Tanaka S,Ichikawa A

更新日期：2001-03-01 00:00:00

abstract：:The selectivity filter and adjacent regions in the bacterial KcsA and inwardly rectifying K(+) (Kir) channels reveal significant conformational changes that cause the channel pore to transition from an activated to inactive state (C-type inactivation) once the channel is open. The meshwork of residues stabilizing the ...

journal_title：Biochemical and biophysical research communications

authors： Raja M

更新日期：2011-09-16 00:00:00

abstract：:Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET) was rationally designed as pure delta-probe from proposed models of mu and delta opiate receptors. On peripheral organs, deltakephalin displays a 3000 times higher inhibitory potency on the electrically stimulated mouse vas deferens (IC50 = 0.15 nM) as on the guinea pig...

journal_title：Biochemical and biophysical research communications

authors： Zajac JM,Gacel G,Petit F,Dodey P,Rossignol P,Roques BP

更新日期：1983-03-16 00:00:00

abstract：:Upon N-demethylation of caffeine (CA) by rat and human liver microsomes, theobromine (TB), paraxanthine (PX), and theophylline (TP) are produced. The optimal pHs for the formation of TB, PX, and TP from CA by rat liver microsomes are 7.4 (most), 8.2 (minor) and 8.6 (moderate). At pH 7.4, PX is the primary metabolite f...

journal_title：Biochemical and biophysical research communications

authors： Chung WG,Cha YN

更新日期：1997-06-27 00:00:00

abstract：:Translationally controlled tumor protein (TCTP) is often designated as a stress-related protein because of its highly regulated expression in stress conditions. Following a thermal shock, TCTP expression is highly upregulated in a variety of cells. However, at present it is not known whether this upregulation has any ...

journal_title：Biochemical and biophysical research communications

authors： Gnanasekar M,Dakshinamoorthy G,Ramaswamy K

更新日期：2009-08-21 00:00:00

abstract：:It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the capacity to differentiate into cells of endothelial and hepatocyte lineages. The present study shows that beta-catenin-dependent canon...

journal_title：Biochemical and biophysical research communications

authors： Kordes C,Sawitza I,Häussinger D

更新日期：2008-02-29 00:00:00

abstract：:Ras signaling is often dysregulated and plays essential roles for the maintenance of glioblastoma. The proper function of Ras depends largely on the appropriate post-translational modification termed prenylation. Targeting protein prenylation therefore represents an alternative therapeutic strategy in glioblastoma. In...

journal_title：Biochemical and biophysical research communications

authors： Peng P,Wei W,Long C,Li J

更新日期：2017-07-29 00:00:00

abstract：:Cysteine proteases have been identified in parasitic protozoa including the causative agent of Chagas' disease Trypanosoma cruzi. T. cruzi lysates subjected to substrate-containing SDS-polyacrylamide gel electrophoresis exhibit major bands of proteolytic activity in the 45-55 kDa molecular mass range (cruzipain activi...

journal_title：Biochemical and biophysical research communications

authors： Wiser MF,Lonsdale-Eccles JD,D'Alessandro A,Grab DJ

更新日期：1997-11-26 00:00:00

abstract：:Three-week exercise training decreased the steady state level of beta(2)-adrenergic receptor (beta(2)AR) mRNA in peritoneal macrophages from BALB/c mice. When peritoneal macrophages from both exercise-trained and sedentary control mice were stimulated with lipopolysaccharide (LPS), interleukin (IL)-12 mRNA and protein...

journal_title：Biochemical and biophysical research communications

authors： Itoh CE,Kizaki T,Hitomi Y,Hanawa T,Kamiya S,Ookawara T,Suzuki K,Izawa T,Saitoh D,Haga S,Ohno H

更新日期：2004-09-24 00:00:00

abstract：:Microfilaments play an important role in the formation of apoptotic bodies. This study examined expression patterns of beta-actin, a key component of microfilament, during apoptosis. The data suggest that continuous beta-actin expression is not required for formation of apoptotic bodies. beta-actin mRNA levels rapidly...

journal_title：Biochemical and biophysical research communications

authors： Naora H,Naora H

更新日期：1995-06-15 00:00:00

abstract：:We recently developed the cellular model MVLN-15 in which estrogenic action can be detected by bioluminescence. Using this cellular model, we characterized the inhibitory effect of retinoic acid on the estrogen-dependent induction of luciferase transcription. We present evidence that i) the inhibitory effect of retino...

journal_title：Biochemical and biophysical research communications

authors： Demirpence E,Pons M,Balaguer P,Gagne D

更新日期：1992-02-28 00:00:00

abstract：:Enterovirus 71 (EV71) is a major causative agent for hand, foot and mouth disease (HFMD), and fatal neurological and systemic complications in children. However, there is currently no clinical approved antiviral drug available for the prevention and treatment of the viral infection. Here, we evaluated the antiviral ac...

journal_title：Biochemical and biophysical research communications

authors： Zhang W,Tao J,Yang X,Yang Z,Zhang L,Liu H,Wu K,Wu J

更新日期：2014-07-04 00:00:00

abstract：:Obesity continues to be one of the most prominent public health dilemmas in the world. The complex interaction among the varied causes of obesity makes it a particularly challenging problem to address. While typical high-fat purified diets successfully induce weight gain in rodents, we have described a more robust mod...

journal_title：Biochemical and biophysical research communications

authors： Johnson AR,Wilkerson MD,Sampey BP,Troester MA,Hayes DN,Makowski L

更新日期：2016-04-29 00:00:00

abstract：:Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running ...

journal_title：Biochemical and biophysical research communications

authors： Soya H,Nakamura T,Deocaris CC,Kimpara A,Iimura M,Fujikawa T,Chang H,McEwen BS,Nishijima T

更新日期：2007-07-13 00:00:00

abstract：:D-ribose is cytotoxic for quiescent human lymphocytes and severely inhibits their PHA-induced proliferation at concentrations (25-50 mM) at which other simple sugars are ineffective. In order to explain these effects, DNA repair synthesis was evaluated in PHA-stimulated human lymphocytes treated with hydroxyurea and i...

journal_title：Biochemical and biophysical research communications

authors： Zunica G,Marini M,Brunelli MA,Chiricolo M,Franceschi C

更新日期：1986-07-31 00:00:00

abstract：:Cell division cycle protein 45 (Cdc45) is crucial for the initiation as well as the elongation process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is ubiquitylated and degraded by the proteasome pathway in human cells. Firstly, the fate of Cdc45 protein after induction of terminal diff...

journal_title：Biochemical and biophysical research communications

authors： Pollok S,Grosse F

更新日期：2007-11-03 00:00:00

abstract：:To investigate the role of myotonin-protein kinase (MT-PK) in the pathophysiology of myotonic dystrophy (DM), we developed specific antibodies against synthetic MT-PK peptides. The antibody identified a 53kDa protein in skeletal muscle and recognized decreases in the amount of the protein in both adult and congenital ...

journal_title：Biochemical and biophysical research communications

authors： Koga R,Nakao Y,Kurano Y,Tsukahara T,Nakamura A,Ishiura S,Nonaka I,Arahata K

更新日期：1994-07-15 00:00:00

abstract：:Cardiac fibrosis is one of the primary mechanisms of ventricular remodeling, and there is no effective method for reversal. Activation of calcium sensing receptor (CaSR) has been reported to be involved in the development of myocardial fibrosis, but the molecular mechanism for CaSR activation has not yet been clarifie...

journal_title：Biochemical and biophysical research communications

authors： Chi J,Wang L,Zhang X,Fu Y,Liu Y,Chen W,Liu W,Shi Z,Yin X

更新日期：2018-03-04 00:00:00

abstract：:The activity of ABC294640, a small-molecular sphingosine kinase 2 (SphK2) inhibitor, in human skin squamous cell carcinoma (SCC) cells was tested in this study. SphK2 mRNA and protein are expressed in established (A431 cheilocarcinoma cell line) and primary human skin SCC cells. ABC294640 dose-dependently inhibited su...

journal_title：Biochemical and biophysical research communications

authors： Zhou J,Chen J,Yu H

更新日期：2018-03-04 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD(+). The function of PARP-1 is related to important nuclear processes including DNA repair and transcription. Previous studies demonstrated a specific physical interaction between PARP-1 and the trans...

journal_title：Biochemical and biophysical research communications

authors： Oei SL,Shi Y

更新日期：2001-06-08 00:00:00

abstract：:The objective of the present study is to demonstrate that a newly developed selective c-Fos/activator protein (AP)-1 inhibitor, T-5224, inhibits the expression of matrix metalloproteinases (MMPs) in human articular chondrocytes, and prevents cartilage destruction in an osteoarthritis (OA)-induced mouse model. First, w...

journal_title：Biochemical and biophysical research communications

authors： Motomura H,Seki S,Shiozawa S,Aikawa Y,Nogami M,Kimura T

更新日期：2018-03-04 00:00:00

abstract：:Receptor-mediated regulation of guanylate cyclase is well-studied in intact Dictyostelium discoideum cells, but study of the enzyme in cell-free preparations has hampered. A major obstacle has been that in vitro guanylate cyclase activity could be detected only in the presence of unphysiological concentrations of Mn2+...

journal_title：Biochemical and biophysical research communications

authors： Janssens PM,de Jong CC

更新日期：1988-01-15 00:00:00

abstract：:Insulin and glucagon secretion from the islets of Langerhans is highly regulated. Although an increased plasma glucose level is the major stimulus for insulin exocytosis, roles for glutamine and glutamate have been suggested. Interestingly, the islet cells display elements associated with synaptic transmission. In the...

journal_title：Biochemical and biophysical research communications

authors： Gammelsaeter R,Jenstad M,Bredahl MK,Gundersen V,Chaudhry FA

更新日期：2009-04-10 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson's disease (PD), but its true physiological function remains unknown. In the normal mouse, LRRK2 is expressed in kidney, spleen, and lung at much higher levels than in brain, suggesting that LRRK2 may play an important role in these organ...

journal_title：Biochemical and biophysical research communications

authors： Maekawa T,Kubo M,Yokoyama I,Ohta E,Obata F

更新日期：2010-02-12 00:00:00

abstract：:Preproenkephalin A messenger RNA was detected in hamster heart by Northern blot analysis using a human preproenkephalin A cDNA probe. Ventricular levels of this messenger were one order of magnitude lower than atrial levels, which were equivalent to brain levels. Furthermore, in the heart of cardiomyopathic hamsters, ...

journal_title：Biochemical and biophysical research communications

authors： Ouellette M,Brakier-Gingras L

更新日期：1988-08-30 00:00:00

abstract：:Light-induced conformational changes occurring at the cytosolic surface of rhodopsin were investigated by performing limited digestions of native and illuminated visual pigment with thermolysin, Arg-C endoproteinase, papain and proteinase K. A higher susceptibility of the extradiscal regions of the bleached pigment to...

journal_title：Biochemical and biophysical research communications

authors： Pellicone C,Nullans G,Cook NJ,Virmaux N

更新日期：1985-03-29 00:00:00

abstract：:Pulmonary fibrosis is a progressive disorder whose molecular pathology is poorly understood. Here we developed an in-house cDNA microarray ("lung chip") originating from a lung-normalized cDNA library. By using this lung chip, we analyzed global gene expression in a murine model of bleomycin-induced fibrosis and selec...

journal_title：Biochemical and biophysical research communications

authors： Katsuma S,Nishi K,Tanigawara K,Ikawa H,Shiojima S,Takagaki K,Kaminishi Y,Suzuki Y,Hirasawa A,Ohgi T,Yano J,Murakami Y,Tsujimoto G

更新日期：2001-11-09 00:00:00

abstract：:MK is a gene whose expression increases transiently during retinoic acid-induced differentiation of embryonal carcinoma cells. MK polypeptide was secreted by differentiating HM-1 embryonal carcinoma cells and by L-cells transfected with an MK cDNA under the control of the beta-actin promoter and Rous sarcoma virus enh...

journal_title：Biochemical and biophysical research communications

authors： Tomomura M,Kadomatsu K,Nakamoto M,Muramatsu H,Kondoh H,Imagawa K,Muramatsu T

更新日期：1990-09-14 00:00:00

abstract：:Monoclonal antibodies are essential to the success of molecularly targeted therapies. Recently, numerous therapeutic antibodies have been developed for various diseases, including cancer and autoimmune diseases. Experimental systems to effectively evaluate these candidate antibodies are urgently needed. One of the mec...

journal_title：Biochemical and biophysical research communications

authors： Shiokawa M,Takahashi T,Murakami A,Kita S,Ito M,Sugamura K,Ishii N

更新日期：2010-09-03 00:00:00

abstract：:The effect of eicosapentaenoic acid (EPA) on natural killer (NK) cell activity of human lymphocytes was examined. The addition of an emulsion of trieicosapentaenoyl-glycerol (EPA-TG) emulsified with purified phosphatidylcholine from krill to a cytotoxicity assay system resulted in a marked depression of NK activity. T...

journal_title：Biochemical and biophysical research communications

authors： Yamashita N,Yokoyama A,Hamazaki T,Yano S

更新日期：1986-08-14 00:00:00