A novel nucleic acid analogue shows strong angiogenic activity.

abstract：:Mitogen-activated protein kinases (MPKs) are involved in a number of signaling pathways that control plant development and stress tolerance via the phosphorylation of target molecules. However, so far only a limited number of target molecules have been identified. Here, we provide evidence that MYB41 represents a new ...

journal_title：Biochemical and biophysical research communications

authors： Hoang MH,Nguyen XC,Lee K,Kwon YS,Pham HT,Park HC,Yun DJ,Lim CO,Chung WS

更新日期：2012-05-25 00:00:00

abstract：:In hematopoietic cells, Ras has been implicated in signaling pathways that prevent apoptosis triggered by deprivation of cytokines, such as interleukin-3 (IL-3). However, the mechanism whereby Ras suppresses cell death remains incompletely understood. We have investigated the role of Ras in IL-3 signal transduction by...

journal_title：Biochemical and biophysical research communications

authors： Terada K,Kaziro Y,Satoh T

更新日期：2000-01-07 00:00:00

abstract：:We have determined the nucleotide sequence of a bovine lens alpha A2-crystallin cDNA clone, designated pBL alpha A2-1. The 793 bp cDNA insert contains coding information for the entire 173 amino acid alpha A2-crystallin polypeptide, as well as non-translated sequences located both upstream and downstream from the codi...

journal_title：Biochemical and biophysical research communications

authors： Hay RE,Petrash JM

更新日期：1987-10-14 00:00:00

abstract：:The genome of a novel foot-and-mouth disease virus, HKN/2002, was 8104 nucleotides (nt) in length (excluding the poly(C) tract and poly(A) tail) and was composed of a 1042-nt 5'-untranslated region (UTR), a 6966-nt open reading frame, and a 93-nt 3'-UTR. Genome sequences of HKN/2002 and other known FMDV strains were c...

journal_title：Biochemical and biophysical research communications

authors： Feng Q,Yu H,Liu Y,He C,Hu J,Sang H,Ding N,Ding M,Fung YW,Lau LT,Yu AC,Chen J

更新日期：2004-10-08 00:00:00

abstract：:Alzheimer's disease is a growing concern in the context of the increasing lifespan of the populations. The work presented here is part of the fight against this threat. It supports a therapeutic approach to reduce the incidence of Alzheimer's disease, taking advantage of the specific binding of several domains of Netr...

journal_title：Biochemical and biophysical research communications

authors： Borel F,Marzocca F,Delcros JG,Rama N,Mehlen P,Ferrer JL

更新日期：2017-07-01 00:00:00

abstract：:The production of 1 alpha,25-dihydroxyvitamin D3 is known to be down regulated by 1 alpha,25-dihydroxyvitamin D3 itself. It was recently shown that liver mitochondrial sterol 27-hydroxylase CYP27, present also in kidney, catalyzes 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Treatment of vitamin D-deficient rats wit...

journal_title：Biochemical and biophysical research communications

authors： Axén E,Postlind H,Wikvall K

更新日期：1995-10-04 00:00:00

abstract：:Considering the number of cytosolic proteins associated with many diseases, development of cytosol-penetrating molecules from outside of living cells is highly in demand. To gain access to the cytosol after cellular uptake, cell-penetrating molecules should be released from intermediate endosomes prior to the lysosoma...

journal_title：Biochemical and biophysical research communications

authors： Kim JS,Choi DK,Park SW,Shin SM,Bae J,Kim DM,Yoo TH,Kim YS

更新日期：2015-11-27 00:00:00

abstract：:Anchoring protein alphaKAP targets calmodulin kinase II (CaMKII) to the sarcoplasmic reticulum (SR), and in the rabbit is a substrate of CaMKII itself in fast-twitch, but not in slow-twitch muscle. This work was aimed at elucidating the molecular basis for differential phosphorylation of alphaKAP. Here we show that tw...

journal_title：Biochemical and biophysical research communications

authors： Damiani E,Sacchetto R,Salviati L,Margreth A

更新日期：2003-02-28 00:00:00

abstract：:The most widely used rate expression for single-substrate enzyme catalyzed reactions, namely the Michaelis-Menten kinetics is based upon the assumption that enzyme concentration is in excess of the substrate in the medium and the rate is mainly limited by the substrate concentration according to saturation kinetics. H...

journal_title：Biochemical and biophysical research communications

authors： Kargi F

更新日期：2009-04-24 00:00:00

abstract：:Hydrogenovibrio marinus strain MH-110, an obligately lithoautotrophic hydrogen-oxidizing bacterium, possesses three sets of the genes for ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO): namely, two form I type (cbbLS-1 and cbbLS-2) and one form II type (cbbM) enzymes. The cbbQ-m gene was located downstream ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi NR,Arai H,Kodama T,Igarashi Y

更新日期：1999-11-01 00:00:00

abstract：:Leber's hereditary optic neuropathy (LHON) has been associated with "primary" and "secondary" mtDNA missense point mutations, and a synergistic role has been proposed for secondary mutations. No previous study has investigated the effects of LHON primary or primary plus secondary mutations on the respiratory competenc...

journal_title：Biochemical and biophysical research communications

authors： Vergani L,Martinuzzi A,Carelli V,Cortelli P,Montagna P,Schievano G,Carrozzo R,Angelini C,Lugaresi E

更新日期：1995-05-25 00:00:00

abstract：:The trans-translation system in bacteria promotes recycling of stalled ribosomes and targets incomplete peptides for proteolysis. In Escherichia coli, loss of trans-translation function has little effect on growth under normal laboratory conditions. Among the subtle phenotypes of tmRNA-deficient mutants is the inabili...

journal_title：Biochemical and biophysical research communications

authors： O'Connor M

更新日期：2007-05-25 00:00:00

abstract：:Hsa-microRNA-187-3p (miR-187-3p) has recently been discovered having anticancer efficacy in different organs. However, the role of miR-187-3p on non-small cell lung cancer (NSCLC) is still ambiguous. In this study, we investigated the role of miR-187-3p on the development of NSCLC. The results indicated that miR-187-3...

journal_title：Biochemical and biophysical research communications

authors： Sun C,Li S,Yang C,Xi Y,Wang L,Zhang F,Li D

更新日期：2016-02-26 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:Orally ingested botulinum toxin enters the circulatory system and eventually reaches the peripheral nerves, where it elicits a response of neurological dysfunction. In this study, we report the important findings concerning the mechanism of Clostridium botulinum type C progenitor toxin (C16S) endocytic mechanism. C16S...

journal_title：Biochemical and biophysical research communications

authors： Nishikawa A,Uotsu N,Arimitsu H,Lee JC,Miura Y,Fujinaga Y,Nakada H,Watanabe T,Ohyama T,Sakano Y,Oguma K

更新日期：2004-06-25 00:00:00

abstract：:Glycosylation mutants of chinese hamster ovary cells were used to analyse the role played by surface-exposed carbohydrates on the process of interaction of Trypanosoma cruzi with the host cell. Adhesion and invasion of the parasites were markedly reduced in cells which express very few sialic acid residues. Infection ...

journal_title：Biochemical and biophysical research communications

authors： Ciavaglia Mdo C,de Carvalho TU,de Souza W

更新日期：1993-06-15 00:00:00

abstract：:A prolyl isomerase Pin1 deficient (Pin1-/-) male mice had severe testicular atrophy. We investigated the function of Pin1 in spermatogenesis by analyzing the Pin1-/- mice at reproductive age. Pin1-/- mice had lessαPLZF positive spermatogonia (undifferentiated spermatogonia) than wild type (WT). Nevertheless, the Pin1-...

journal_title：Biochemical and biophysical research communications

authors： Kurita-Suzuki A,Kamo Y,Uchida C,Tanemura K,Hara K,Uchida T

更新日期：2018-02-26 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) belongs to the Nkx family of homeodomain-containing proteins and regulates expression of several important genes in the brain. Our previous studies showed that TTF-1 plays an important role in water homeostasis in the subfornical organ of rats and is involved in cerebrospinal flu...

journal_title：Biochemical and biophysical research communications

authors： Kim JG,Bae KD,Yun CH,Im HL,Park JW,Nam-Goong IS,Kim YI,Lee BJ

更新日期：2008-06-06 00:00:00

abstract：:Human PTK7 is a defective receptor protein tyrosine kinase and its expression is upregulated in various cancers including colorectal carcinomas. To determine whether PTK7 functions in angiogenesis, we have expressed and purified the extracellular domain of PTK7 (soluble PTK7; sPTK7) as a decoy receptor to counteract t...

journal_title：Biochemical and biophysical research communications

authors： Shin WS,Maeng YS,Jung JW,Min JK,Kwon YG,Lee ST

更新日期：2008-07-11 00:00:00

abstract：:We report that N-oleoylethanolamine (NOE), widely employed as a ceramidase inhibitor, also inhibits glucosylation of naturally occurring ceramides. When CHP-100 neuroepithelioma cells were exposed for 18h to non-toxic NOE concentrations (i.e. up to 70 microM), basal incorporation of labelled hexose into glucosylcerami...

journal_title：Biochemical and biophysical research communications

authors： Spinedi A,Di Bartolomeo S,Piacentini M

更新日期：1999-02-16 00:00:00

abstract：:The growth of DU-145 human prostate carcinoma cells is reduced to 50% of control by 1 X 10(-6) M to 2 X 10(-6) M selenium and to 2% of control at 10(-4)M selenium. These cells show greater sensitivity to inhibition of growth or DNA synthesis by selenium than human W1-38 and HeLa cells and mouse mammary tumor cells. It...

journal_title：Biochemical and biophysical research communications

authors： Webber MM,Perez-Ripoll EA,James GT

更新日期：1985-07-31 00:00:00

abstract：:The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

journal_title：Biochemical and biophysical research communications

authors： Tiong TS,Herington AC

更新日期：1991-10-31 00:00:00

abstract：:It has been proposed that the members of the hsp70 major heat shock protein family in non-stressed cells participate in the intracellular transport of newly synthesized proteins and in maintaining such proteins in an unfolded state. Specific binding of other cellular proteins to hsp70 may play a role in hsp70 function...

journal_title：Biochemical and biophysical research communications

authors： Margulis BA,Welsh M

更新日期：1991-07-15 00:00:00

abstract：:The binding properties of Bacillus thuringiensis toxins to brush border membrane vesicles of Dipel-resistant and -susceptible Ostrinia nubilalis larvae were compared using ligand-toxin immunoblot analysis, surface plasmon resonance (SPR), and radiolabeled toxin binding assays. In ligand-toxin immunoblot analysis, the ...

journal_title：Biochemical and biophysical research communications

authors： Li H,González-Cabrera J,Oppert B,Ferré J,Higgins RA,Buschman LL,Radke GA,Zhu KY,Huang F

更新日期：2004-10-08 00:00:00

abstract：:Sphingolipids have been reported to regulate the growth and death of mammalian and yeast cells, but their precise mechanisms are unknown. In this paper, it was shown that the deletion of the oxysterol binding protein homologue 3 (OSH3) gene confers hyper resistance against ISP-1, an inhibitor of sphingolipid biosynthe...

journal_title：Biochemical and biophysical research communications

authors： Yano T,Inukai M,Isono F

更新日期：2004-02-27 00:00:00

abstract：:We have reported previously that X-irradiated MOLT-4 cells during their rapid cell death exhibited dose and time dependently a new protein named p41 detected by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). An antibody, AM-1, raised against partial peptide of p41 stained two spots, p41 and p42, unexpe...

journal_title：Biochemical and biophysical research communications

authors： Morita A,Suzuki N,Matsumoto Y,Hirano K,Enomoto A,Zhu J,Sakai K

更新日期：2000-11-30 00:00:00

abstract：:Growing evidences show that functionally relevant polymorphisms in various promoters alter both transcriptional activity and affinities of existing protein-DNA interactions, and thus influence disease progression in humans. We previously reported the -94G>T CFTR promoter variant in a female CF patient in whom any know...

journal_title：Biochemical and biophysical research communications

authors： Taulan M,Lopez E,Guittard C,René C,Baux D,Altieri JP,DesGeorges M,Claustres M,Romey MC

更新日期：2007-09-28 00:00:00

abstract：:Jasmonates are plant lipid-derived oxylipins that act as key signaling compounds in plant immunity, germination, and development. Although some physiological activities of natural jasmonates in mammalian cells have been investigated, their anti-inflammatory actions in mammalian cells remain unclear. Here, we investiga...

journal_title：Biochemical and biophysical research communications

authors： Taki-Nakano N,Kotera J,Ohta H

更新日期：2016-05-13 00:00:00

abstract：:The acyclic nucleotide analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] is a potent and selective inhibitor of African swine fever virus (ASFV) replication. Using the DNA-DNA hybridization technique with plasmid pRPEL-2 as probe, we have shown that (S)-HPMPA exerts a specific, dose-dependent, in...

journal_title：Biochemical and biophysical research communications

authors： Arzuza O,García-Villalón D,Tabarés E,Gil-Fernández C,De Clercq E

更新日期：1988-07-15 00:00:00

abstract：:Ammonia-forming cytochrome c nitrite reductase from Sulfurospirillum deleyianum contains four covalently bound heme c groups/55 kDa subunit as determined by atomic absorption spectroscopy and the pyridine Fe(II)-hemochrome technique. Nitrite reductase was isolated from the membrane fraction as a monomer (M(r) 55 +/- 2...

journal_title：Biochemical and biophysical research communications

authors： Schumacher W,Hole U,Kroneck PM

更新日期：1994-11-30 00:00:00