Inhibition of African swine fever virus DNA synthesis by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.

Abstract:

:The acyclic nucleotide analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] is a potent and selective inhibitor of African swine fever virus (ASFV) replication. Using the DNA-DNA hybridization technique with plasmid pRPEL-2 as probe, we have shown that (S)-HPMPA exerts a specific, dose-dependent, inhibitory effect on viral DNA synthesis. Also, (S)-HPMPA inhibits the production of late viral proteins, especially IP-73, in ASFV-infected MS and Vero cells. When evaluated under the same experimental conditions, phosphonoacetic acid (PAA) also caused an inhibition of viral DNA and late viral protein synthesis but only so at a concentration which was 10- to 20-fold higher than that required for (S)-HPMPA.

authors

Arzuza O,García-Villalón D,Tabarés E,Gil-Fernández C,De Clercq E

doi

10.1016/0006-291x(88)90644-4

subject

Has Abstract

pub_date

1988-07-15 00:00:00

pages

27-32

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90644-4

journal_volume

154

pub_type

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