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Interaction of Trypanosoma cruzi with cells with altered glycosylation patterns.

Abstract：

:Glycosylation mutants of chinese hamster ovary cells were used to analyse the role played by surface-exposed carbohydrates on the process of interaction of Trypanosoma cruzi with the host cell. Adhesion and invasion of the parasites were markedly reduced in cells which express very few sialic acid residues. Infection levels similar to those obtained with the parental cell could be obtained after sialylation of the mutant cell using exogenous fetuin as sialic acid donor and T. cruzi trans-sialidase. The results obtained show that host cell sialic acid residues are involved in the process of attachment to and penetration of T. cruzi into the host cell.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ciavaglia Mdo C,de Carvalho TU,de Souza W

doi

10.1006/bbrc.1993.1684

subject

Has Abstract

pub_date

1993-06-15 00:00:00

pages

718-21

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X83716840

journal_volume

193

pub_type

杂志文章

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