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Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.

Abstract：

:A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50 = 4.1 to < 0.5 nM) were synthesized. Aqueous solubilities of this series of compounds were improved by incorporating polar functional groups at the P1' P2 and P2' positions. These compounds also possess good anti-viral activity by inhibition of the cytopathic effect of HIV-13B in MT-4 cells in vitro.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sham HL,Zhao C,Marsh KC,Betebenner DA,Lin S,Rosenbrook W Jr,Herrin T,Li L,Madigan D,Vasavanonda S,Molla A,Saldivar A,McDonald E,Wideburg NE,Kempf D,Norbeck DW,Plattner JJ

doi

10.1006/bbrc.1996.1191

subject

Has Abstract

pub_date

1996-08-14 00:00:00

pages

436-40

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X96911912

journal_volume

225

pub_type

杂志文章

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