TGF-beta1 induced MMP-9 expression in HNSCC cell lines via Smad/MLCK pathway.

abstract：:T Kininogen and High Molecular Weight Kininogen were characterized in the cell culture medium of Fao cells, a highly differentiated cell line derived from the Reuber H35 rat hepatoma. Immunoreactive T Kininogen and High Molecular Weight Kininogen identified by direct and specific RIAs were indistinguishable from stand...

journal_title：Biochemical and biophysical research communications

authors： Baussant T,Michaud A,Bouhnik J,Savoie F,Alhenc-Gelas F,Corvol P

更新日期：1988-08-15 00:00:00

abstract：:The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS, proteins are Ub-labeled for degradation by Ub ligases conferring substrate specificity. The CSN controls a large family of Ub ligases called cullin-RING ligases (CRLs), which ubiquitinate cell cycle regulators, transcr...

journal_title：Biochemical and biophysical research communications

authors： Rockel B,Schmaler T,Huang X,Dubiel W

更新日期：2014-07-25 00:00:00

abstract：:N-Palmitoyl-(S)-seryl-(S)-seryl-(S)-asparaginyl-(S)-alanine (Palmitoyl-tetrapeptide) is an analogue of the N-terminal part of the lipoprotein from the outer membrane of Escherichia coli. It was prepared by chemical synthesis and tested for biological activity in in vitro lymphocyte culture systems. In spleen cells of ...

journal_title：Biochemical and biophysical research communications

authors： Bessler WG,Cox M,Wiesmüller KH,Jung G

更新日期：1984-05-31 00:00:00

abstract：:Pyrrolidine dithiocarbamate (PDTC) is a metal chelating compound that can exert either pro-oxidant or antioxidant effects in different situations. Several studies demonstrate that it can inhibit cyclooxygenase-2 (COX-2) expression, which may be due to its antioxidant activity. Here, we found that PDTC rather increased...

journal_title：Biochemical and biophysical research communications

authors： Lee JE,Kim KM,Cho JW,Suh SI,Suh MH,Kwon TK,Park JW,Bae JH,Song DK,Cho CH,Bae I,Baek WK

更新日期：2002-10-25 00:00:00

abstract：:Several studies have demonstrated that connexin 43 (Cx43) mediates signals important for osteoblast function and osteogenesis. The role of gap junctional communication in bone resorption is less clear. We have investigated the expression of Cx43 mRNA in osteoclasts and bone resorption cultures and furthermore, the fun...

journal_title：Biochemical and biophysical research communications

authors： Ransjö M,Sahli J,Lie A

更新日期：2003-04-18 00:00:00

abstract：:A fusion protein comprising the DNA-binding region of the glucocorticoid receptor and the catalytic domain of poly(ADP-ribose) polymerase was constructed. This chimeric protein was expressed both in E. coli and in eukaryotic cells and was recognized by antibodies to both polymerase and the glucocorticoid receptor. Sim...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal D,Hong T,Cherney B,Zhang S,Shima T,Danielsen M,Smulson M

更新日期：1994-07-29 00:00:00

abstract：:The thiazide-sensitive Na-Cl cotransporter SLC12A3 displays expression restricted to distal convoluted tubule cells where it catalyzes the uptake of sodium and chloride through the apical membrane. We sequenced 1959 bp of the 5' flanking region of human SLC12A3, located the area of transcription initiation, and used d...

journal_title：Biochemical and biophysical research communications

authors： MacKenzie S,Vaitkevicius H,Lockette W

更新日期：2001-04-13 00:00:00

abstract：:Complementation studies, using fused cell lines from patients with peroxisomal disorders, have shown correction of defective plasmalogen synthesis and phytanic acid oxidation as well as an increase in the number of peroxisomes. At least six complementation groups have been reported. We demonstrate here that complement...

journal_title：Biochemical and biophysical research communications

authors： McGuinness MC,Moser AB,Moser HW,Watkins PA

更新日期：1990-10-15 00:00:00

abstract：:Antigen-transporting cells take up pathogens, and then migrate from sites of inflammation to secondary lymphoid tissues to induce an immune response. Among antigen-transporting cells, dendritic cells (DCs) are believed to be the most potent and professional antigen-presenting cells that can stimulate naïve T cells. Ho...

journal_title：Biochemical and biophysical research communications

authors： Terasawa M,Nagata K,Kobayashi Y

更新日期：2008-12-12 00:00:00

abstract：:Ambroxol is often used as a mucolytic agent in various lung diseases. However, it is unclear how ambroxol acts on bronchial epithelial cells. To clarify the action of ambroxol, we studied the effects of ambroxol on the ion transport in human Calu-3 cells, a human submucosal serous cell line, measuring the transepithel...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa I,Niisato N,Iwasaki Y,Marunaka Y

更新日期：2006-05-05 00:00:00

abstract：:Large tumor suppressor kinase 1 (LATS1) is a serine/threonine kinase of the AGC kinase family in mammals and involved in various biological processes, it is a key regulator of cell cycle progression. However, the role of LATS1 in central nervous system trauma is still unknown. In present study, we performed an acute s...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chen M

更新日期：2018-10-20 00:00:00

abstract：:The appearance of Fas receptor at the surface of pancreatic beta-cells affected by progressive insulitis strongly suggests that Fas-mediated beta-cell apoptosis plays an important role in the pathogenesis of type 1 diabetes. In support of this concept, the present study has shown that islet cells from NOD mice and the...

journal_title：Biochemical and biophysical research communications

authors： Augstein P,Dunger A,Salzsieder C,Heinke P,Kubernath R,Bahr J,Fischer U,Rettig R,Salzsieder E

更新日期：2002-01-11 00:00:00

abstract：:Wild type p53 protein requires posttranslational modification within a carboxy-terminal negative regulatory domain to activate DNA binding and transcription. Binding of monoclonal antibody PAb421 to the carboxy-terminal domain reproduces this activation. In the absence of PAb421, we found that wild type p53 bound acti...

journal_title：Biochemical and biophysical research communications

authors： Kaku S,Albor A,Kulesz-Martin M

更新日期：2001-01-12 00:00:00

abstract：:Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2. A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibi...

journal_title：Biochemical and biophysical research communications

authors： Lu G,Xu C,Tang K,Zhang J,Li Q,Peng L,Wang Y,Huang Z,Gao X

更新日期：2017-01-29 00:00:00

abstract：:Serotype conversion (O-antigen glucosylation) in Shigella flexneri is mediated by temperate bacteriophages, which encode a three-gene cluster that contains gtrA, gtrB, and gtr([type]). Sequence analysis has revealed that gtrA and gtrB are conserved and readily interchangeable between serotypes. The gtr([type]) is uniq...

journal_title：Biochemical and biophysical research communications

authors： Korres H,Mavris M,Morona R,Manning PA,Verma NK

更新日期：2005-03-25 00:00:00

abstract：:We determined the cDNA sequence for neurocalcin, a novel calcium-binding protein in bovine brain. This clone (pCalN) has 582 nucleotides in the open reading frame including the termination codon TGA, 11 nucleotides of the 5' leader and 1251 nucleotides of the 3' noncoding region. The deduced amino acid sequence reveal...

journal_title：Biochemical and biophysical research communications

authors： Okazaki K,Watanabe M,Ando Y,Hagiwara M,Terasawa M,Hidaka H

更新日期：1992-05-29 00:00:00

abstract：:Mouse hepatoma Hepa-1c1c7 (Hepa-1) cells were treated with myristicin to assess the role of myristicin in the process of Cyp1a-1 induction. Treatment of Hepa-1 cells with myristicin increased Cyp1a-1 transcription in a dose-dependent manner as shown by analysis of 7-ethoxyresorufin O-deethylase activity, Cyp1a-1 prote...

journal_title：Biochemical and biophysical research communications

authors： Jeong HG,Lee SS,Kim HK,Yang KH

更新日期：1997-04-28 00:00:00

abstract：:Phospholipase D has been implicated as an important enzyme in a range of cellular responses, including regulated secretion and the formation of secretory vesicles, cell proliferation and control of cell morphology. As insulin treatment of adipocytes has been shown to stimulate a phosphatidylcholine-specific phospholip...

journal_title：Biochemical and biophysical research communications

authors： Millar CA,Jess TJ,Saqib KM,Wakelam MJ,Gould GW

更新日期：1999-01-27 00:00:00

abstract：:A voltage-dependent K+ current has been revealed in whole-cell recordings carried out on immortalized cells obtained from the human tracheal epithelium. At positive membrane potentials the current shows a time dependent inactivation which is accelerated by increasing the depolarizing step. Forskolin, a direct activato...

journal_title：Biochemical and biophysical research communications

authors： Galietta LJ,Rasola A,Barone V,Gruenert DC,Romeo G

更新日期：1991-09-30 00:00:00

abstract：:Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide depende...

journal_title：Biochemical and biophysical research communications

authors： Kawauchi K,Shibutani K,Yagisawa H,Kamata H,Nakatsuji S,Anzai H,Yokoyama Y,Ikegami Y,Moriyama Y,Hirata H

更新日期：1997-08-28 00:00:00

abstract：:The purpose of this study was to identify mammalian cell line(s) which possess intrinsic enzymatic activity of beta-carotene 15, 15'-dioxygenase. This enzyme (EC1.13.11.21) converts beta-carotene to retinal (precursor of retinol and retinoic acid). To assess activity, cellular enzyme preparations were incubated with b...

journal_title：Biochemical and biophysical research communications

authors： During A,Albaugh G,Smith JC Jr

更新日期：1998-08-19 00:00:00

abstract：:The cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) is believed to arise as a consequence of its time- and energy-dependent accumulation inside mitochondria, followed by inhibition of electron transport at Complex I of the respiratory chain. Consistent with our proposal that the accumulation of MPP+ represents a pa...

journal_title：Biochemical and biophysical research communications

authors： Sayre LM,Wang F,Hoppel CL

更新日期：1989-06-15 00:00:00

abstract：:HDAC3, one of the class I histone deacetylase modulates epigenetic landscape through histone modification. HDAC3 also interacts with non-histone proteins including p53 for deacetylation. Moreover, HDAC3 serves as a transcriptional repressor, interacting with NCor1/SMRT complex. Although HDAC3 plays a critical role for...

journal_title：Biochemical and biophysical research communications

authors： Choi YM,An S,Bae S,Jung JH

更新日期：2019-09-17 00:00:00

abstract：:Ribosome modulation factor (RMF) is involved in stabilization of ribosomes during the transition from exponential growth to the stationary growth phase in Escherichia coli. A deficiency of RMF is known to reduce cell viability. Overaccumulation of spermidine also leads to a decrease in cell viability and to a decrease...

journal_title：Biochemical and biophysical research communications

authors： Apirakaramwong A,Fukuchi J,Kashiwagi K,Kakinuma Y,Ito E,Ishihama A,Igarashi K

更新日期：1998-10-20 00:00:00

abstract：:Epigenetic modifications such as DNA methylation and histone H3 lysine 27 methylation (H3K27me) are repressive marks that silence gene expression. The M phase phosphoprotein (MPP8) associates with proteins involved in both DNA methylation and histone modifications, and therefore, is a potential candidate to mediate cr...

journal_title：Biochemical and biophysical research communications

authors： Murata K,Sato S,Haruta M,Goshima T,Chiba Y,Takahashi S,Sharif J,Koseki H,Nakanishi M,Shimada M

更新日期：2015-03-13 00:00:00

abstract：:Although D-glucosamine has been reported as an inhibitor of tumor growth both in vivo and in vitro, the mechanism for the anticancer effect of D-glucosamine is still unclear. Since there are several reports suggesting D-glucosamine inhibits protein synthesis, we examined whether D-glucosamine affects p70S6K activity, ...

journal_title：Biochemical and biophysical research communications

authors： Oh HJ,Lee JS,Song DK,Shin DH,Jang BC,Suh SI,Park JW,Suh MH,Baek WK

更新日期：2007-09-07 00:00:00

abstract：:Previous studies have shown that human rhabdomyosarcoma cells are induced to differentiate by TPA, in the absence of appreciable alterations of the muscle regulatory genes and their products (1). The question was addressed whether the tumor suppressor p53 could be a target of TPA action in these cells. Genomic analysi...

journal_title：Biochemical and biophysical research communications

authors： Germani A,Fusco C,Martinotti S,Musarò A,Molinaro M,Zani BM

更新日期：1994-07-15 00:00:00

abstract：:Amidolysis catalysed by nerve growth factor (7S-NGF) and by a glandular kallikrein, unlike that catalysed by thrombin, was not inhibited by antithrombin III, either in the presence or absence of heparin. Inhibition by alpha 1-proteinase inhibitor of thrombin-, but not of 7S-NGF- or kallikrein-catalysed amidolysis was ...

journal_title：Biochemical and biophysical research communications

authors： Long WF,Williamson FB

更新日期：1983-05-31 00:00:00

abstract：:DENN domains are found in a variety of signaling proteins but their exact function remains undefined. Some of the DENN-containing proteins, such as rat Rab3GEP (Rab3 GDP/GTP exchange protein) or mouse Rab6IP1 (Rab6 interacting protein 1) interact with GTPases of the Rab family. Others, such as human MADD (MAP (Mitogen...

journal_title：Biochemical and biophysical research communications

authors： Levivier E,Goud B,Souchet M,Calmels TP,Mornon JP,Callebaut I

更新日期：2001-09-28 00:00:00

abstract：:Bovine heart cytochrome c oxidase, depleted of polypeptide subunits by alkaline detergent treatment, was characterized with respect to metal content, optical spectral properties, and oxidase activity. Treatment with 1.0% Triton X-100 at pH 9.5 followed by anion-exchange chromatography caused removal of subunit III, su...

journal_title：Biochemical and biophysical research communications

authors： Yewey GL,Caughey WS

更新日期：1987-11-13 00:00:00