当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > D-glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K.

D-glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K.

Abstract：

:Although D-glucosamine has been reported as an inhibitor of tumor growth both in vivo and in vitro, the mechanism for the anticancer effect of D-glucosamine is still unclear. Since there are several reports suggesting D-glucosamine inhibits protein synthesis, we examined whether D-glucosamine affects p70S6K activity, an important signaling molecule involved in protein translation. In the present study, we found D-glucosamine inhibited the activity of p70S6K and the proliferation of DU145 prostate cancer cells and MDA-MB-231 breast cancer cells. D-glucosamine decreased phosphorylation of p70S6K, and its downstream substrates RPS6, and eIF-4B, but not mTOR and 4EBP1 in DU145 cells, suggesting that D-glucosamine induced inhibition of p70S6K is not through the inhibition of mTOR. In addition, D-glucosamine enhanced the growth inhibitory effects of rapamycin, a specific inhibitor of mTOR. These findings suggest that D-glucosamine can inhibit growth of cancer cells through dephosphorylation of p70S6K.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Oh HJ,Lee JS,Song DK,Shin DH,Jang BC,Suh SI,Park JW,Suh MH,Baek WK

doi

10.1016/j.bbrc.2007.06.137

subject

Has Abstract

pub_date

2007-09-07 00:00:00

pages

840-5

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01406-4

journal_volume

360

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment.

    abstract：:While Wnt and Ras signaling pathways are activated during progression of colorectal cancers, many of their important downstream targets remain to be elucidated. The gastrin gene encodes for a family of peptide growth factors that are commonly upregulated in colorectal neoplasia. Previously, we showed that the Wnt sign...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.061

    authors： Chakladar A,Dubeykovskiy A,Wojtukiewicz LJ,Pratap J,Lei S,Wang TC

    更新日期：2005-10-14 00:00:00

  • Diversity within the JMJD2 histone demethylase family.

    abstract：:JMJD2A-D belong to the JmjC domain-containing family of histone demethylases. JMJD2D is the most structurally divergent JMJD2 protein as it lacks the PHD and Tudor domains present in JMJD2A-C. Here, we systematically analyzed the histone demethylase specificity of JMJD2 proteins in vivo. We found that JMJD2A and C dem...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.147

    authors： Shin S,Janknecht R

    更新日期：2007-02-23 00:00:00

  • Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins.

    abstract：:The murine cell surface antigen ADAM 15 is a transmembrane glycoprotein that is expressed in a variety of cells including monocytic and T cell lines and consists of a metalloprotease domain, a disintegrin domain, a cysteine-rich domain, and an epidermal growth factor (EGF)-like domain in the extracellular region. The ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.070

    authors： Shimizu E,Yasui A,Matsuura K,Hijiya N,Higuchi Y,Yamamoto S

    更新日期：2003-10-03 00:00:00

  • Human and rat amylin have no effects on insulin secretion in isolated rat pancreatic islets.

    abstract：:Amylin, an islet amyloid peptide secreted by the pancreatic beta cell, has been proposed as a humoral regulator of islet insulin secretion. Four separate preparations of amylin were tested for effects on hormone secretion in both freshly isolated and cultured rat islets and in HIT-T15, hamster insulinoma cells. With a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90628-k

    authors： Broderick CL,Brooke GS,DiMarchi RD,Gold G

    更新日期：1991-06-28 00:00:00

  • Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin.

    abstract：:Lupeol, present in fruits and medicinal plants, is a biologically active compound that has been shown to have various pharmacological properties in experimental studies. In the present study, we demonstrated the modulatory effect of lupeol on 7,12-dimethylbenz[a]anthracene (DMBA)-induced alterations on cell proliferat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.02.033

    authors： Nigam N,Prasad S,George J,Shukla Y

    更新日期：2009-04-03 00:00:00

  • Differential regulation of IGF-II-induced IL-8 by extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinases in human keratinocytes.

    abstract：:In order to study the relationship between insulin like growth factor-II (IGF-II) and interleukin-8 (IL-8) that are upregulated in psoriasis, we monitored IL-8 expression in IGF-II-treated human keratinocytes and explored the signaling pathways of IL-8 expression by IGF-II. IGF-II increased the IL-8 mRNA and protein l...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.042

    authors： Kim HJ,Byun SJ,Kim TY

    更新日期：2004-04-23 00:00:00

  • 55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation.

    abstract：:In virus-infected cells, viral RNA with non-self structural pattern is recognized by DExD/Hbox RNA helicase, RIG-I. Once RIG-I senses viral RNA, it triggers a signaling cascade, resulting in the activation of genes including type I interferon, which activates antiviral responses. Overexpression of N-terminal caspase a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.10.015

    authors： Kageyama M,Takahasi K,Narita R,Hirai R,Yoneyama M,Kato H,Fujita T

    更新日期：2011-11-11 00:00:00

  • Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes.

    abstract：:Green tea catechins have been shown to attenuate obesity in animals and humans. The catechins activate adenosine monophosphate-activated protein kinase (AMPK), and thereby increase fatty acid oxidation in liver and skeletal muscles. Green tea catechins have also been shown to reduce body fat in humans. However, the ef...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.03.158

    authors： Chen S,Osaki N,Shimotoyodome A

    更新日期：2015-05-22 00:00:00

  • FoxA1 as a lineage-specific oncogene in luminal type breast cancer.

    abstract：:The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.11.064

    authors： Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

    更新日期：2008-01-25 00:00:00

  • Transcriptional induction of proto-oncogene fos by HSV-2.

    abstract：:HSV-2 induces the transcription of c-fos gene in both human (diploid) cell strains and mouse (heteroploid) cell lines. HSV-1 is incapable of such induction. The induction of transcription is rapid and transient in both cell types. The product of transcriptional induction of c-fos in mouse cells is mainly a 4.5 kb fos ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90359-7

    authors： Goswami BB

    更新日期：1987-03-30 00:00:00

  • Hepatobiliary excretion of biliverdin isomers and C10-substituted biliverdins in Mrp2-deficient (TR(-)) rats.

    abstract：:Multidrug resistance protein 2 (Mrp2) is considered the major mammalian membrane transporter of non-bile salt organic anions from liver to bile. Using Mrp2-deficient rats, we show that the protein is not essential for biliary excretion of biliverdin, its IIIalpha and XIIIalpha isomers, mesobiliverdin XIIIalpha or bili...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00325-X

    authors： McDonagh AF,Lightner DA,Kar AK,Norona WS

    更新日期：2002-05-10 00:00:00

  • Cell surface n-acetylneuraminic acid alpha2,3-galactoside-dependent intercellular adhesion of human colon cancer cells.

    abstract：:Sialoglycans on the cell surface of human colon cancer (HCC) cells have been implicated in cellular adhesion and metastasis. To clarify the role of N-acetylneuraminic acid (NeuAc) linked alpha2,3 to galactose (Gal) on the surface of HCC cells, we studied the intercellular adhesion of HCC cell lines expressing increasi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0388

    authors： Dimitroff CJ,Pera P,Dall'Olio F,Matta KL,Chandrasekaran EV,Lau JT,Bernacki RJ

    更新日期：1999-03-24 00:00:00

  • PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability.

    abstract：:The transcription factor hypoxia-inducible factor-1 (HIF-1) functions as a master regulator of hypoxic response by inducing the transcription of various genes responsible for cellular adaptation to hypoxia. In this study, we investigated the effects of protein inhibitor of activated STAT3 (PIAS3), a small ubiquitin-re...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.12.047

    authors： Nakagawa K,Kohara T,Uehata Y,Miyakawa Y,Sato-Ueshima M,Okubo N,Asaka M,Takeda H,Kobayashi M

    更新日期：2016-01-15 00:00:00

  • Retroviral suicide vector does not inhibit neointimal growth in a porcine coronary model of restenosis.

    abstract：:We attempted to attenuate neointimal formation following vascular injury using a retroviral suicide vector. Epicardial coronary arteries of adult miniature swine were injured by deployment of oversized tantalum stents. One week later, injured segments were exposed to packaged retroviral constructs with or without the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1157

    authors： Barbee RW,Stapleton DD,Madras DE,Ré RN,Murgo JP,Davenport WD,Giardina J,Cook JL

    更新日期：1995-02-06 00:00:00

  • Zinc dependence of zinT (yodA) mutants and binding of zinc, cadmium and mercury by ZinT.

    abstract：:ZinT (B1973), previously known as YodA, was originally characterised as a cadmium-induced periplasmic protein under the regulation of Fur and SoxS. Here we describe a decrease in zinT transcript in response to elevated copper concentrations and the zinc and copper dependent phenotype of a DeltazinT strain. Cadmium sen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.094

    authors： Kershaw CJ,Brown NL,Hobman JL

    更新日期：2007-12-07 00:00:00

  • Caspase-7 mediated cleavage of proteasome subunits during apoptosis.

    abstract：:Caspase-3 and caspase-7 are structurally closely related and demonstrate overlapping substrate specificity. However, during apoptosis, they are differentially regulated and show distinct subcellular localizations, implying the presence of specific substrates. In this study, to identify caspase-7 substrates, we treated...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.08.183

    authors： Jang M,Park BC,Lee AY,Na KS,Kang S,Bae KH,Myung PK,Chung BC,Cho S,Lee DH,Park SG

    更新日期：2007-11-16 00:00:00

  • Sertoli cell-germ cell interactions and TGF beta 1 expression and secretion in vitro.

    abstract：:Transforming growth factor beta 1 (TGF beta 1) has been reported to be secreted and to act within the somatic cells of the testis. We examined whether the TGF beta 1 expression is present at mRNA and protein levels in purified rat Sertoli cells (SC), purified pachytene spermatocytes (SPC), and early spermatids (SPT) c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7275

    authors： Avallet O,Gomez E,Vigier M,Jégou B,Saez JM

    更新日期：1997-09-29 00:00:00

  • Expression of dystrophin mRNA and the protein in the developing rat heart.

    abstract：:We examined the expression of dystrophin mRNA and the protein in the developing rat heart with polymerase chain reaction, immunoblotting and immunohistochemical analyses. Dystrophin mRNA was detectable on and after the 10th embryonic day, while the protein became detectable during the perinatal period. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90749-d

    authors： Tanaka H,Ozawa E

    更新日期：1990-10-30 00:00:00

  • Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma.

    abstract：:Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.06.021

    authors： Dai Y,Liu L,Zeng T,Zhu YH,Li J,Chen L,Li Y,Yuan YF,Ma S,Guan XY

    更新日期：2013-07-12 00:00:00

  • Suppression of HPV E6 and E7 expression by BAF53 depletion in cervical cancer cells.

    abstract：:Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.098

    authors： Lee K,Lee AY,Kwon YK,Kwon H

    更新日期：2011-08-26 00:00:00

  • Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection.

    abstract：:Mycobacterium tuberculosis (MTB) infection can induce cytotoxicity to the host macrophages, promoting bacterial spread. We here tested the potential effect of oltipraz, a synthetic dithiolethione, in MTB-infected human macrophages. We show that oltipraz significantly inhibited MTB-induced death and apoptosis in human ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.07.026

    authors： Sun Q,Shen X,Ma J,Lou H,Zhang Q

    更新日期：2020-10-20 00:00:00

  • Cloning and partial characterization of Entamoeba histolytica PTPases.

    abstract：:Reversible protein tyrosine phosphorylation is an essential signal transduction mechanism that regulates cell growth, differentiation, mobility, metabolism, and survival. Two genes coding for protein tyrosine phophatases, designed EhPTPA and EhPTPB, were cloned from Entamoeba histolytica. EhPTPA and EhPTPB proteins sh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.055

    authors： Herrera-Rodríguez SE,Baylón-Pacheco L,Talamás-Rohana P,Rosales-Encina JL

    更新日期：2006-04-21 00:00:00

  • Aberrantly expressed lncRNAs identified by microarray analysis in CD4+T cells in asthmatic patients.

    abstract：:The aim of the study was to determine the expression profiles of message RNAs and long non-coding RNAs in CD4+T cells of asthmatic patients and to explore the clinical value and biological function. Expression profiles in CD4+T cells of asthmatic patients and healthy controls were analyzed by microarray. We found 2725...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.07.079

    authors： Qi X,Chen H,Huang Z,Fu B,Wang Y,Xie J,Zhao J,Cao Y,Xiong W

    更新日期：2018-09-10 00:00:00

  • Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells.

    abstract：:Retinoidal activity of retinoic acid isomers [all-trans-retinoic acid (ATRA), 9-cis-retinoic acid (9CRA) and 13-cis-retinoic acid (13CRA)] and their oxidized derivatives [19-hydroxy and 19-oxo derivatives of ATRA (19-hydroxy-ATRA and 19-oxo-ATRA), 19-oxo derivative of 9CRA (19-oxo-9CRA), and 19-hydroxy derivative of 1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)92322-o

    authors： Matsushima Y,Kawachi E,Tanaka H,Kagechika H,Hashimoto Y,Shudo K

    更新日期：1992-12-15 00:00:00

  • A human Fab exclusively binding to the extracellular domain of LMP2A.

    abstract：:In the areas of North Africa, Southeast Asia as well as South China, Nasopharyngeal carcinoma (NPC) is among the most widespread cancers. Plenty of research findings confirmed that Epstein-Barr virus (EBV) played a crucial role in NPC. EBV-encoded Latent membrane protein 2A (LMP2A) which continuously expressed in cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.11.045

    authors： Cao Q,Zhang D,Mao Y,Meng C,Zhu J,Feng Z,Chen R

    更新日期：2017-01-08 00:00:00

  • Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene.

    abstract：:Two genes that hybridize to the cDNA for alcohol-inducible cytochrome P-450 form 3a (P-450ALC) have been isolated from a rabbit genomic library and characterized by restriction mapping, hybridization, and partial sequence analysis. The genes show extensive sequence similarity as judged by hybridization at high stringe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90479-2

    authors： Khani SC,Porter TD,Coon MJ

    更新日期：1988-01-15 00:00:00

  • Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts.

    abstract：:Connexin 43 (Cx43), a ubiquitous connexin expressed in the heart and skin, is associated with a variety of hereditary conditions. Therefore, the characterization of Cx43-interacting proteins and their dynamics is important to understand not only the molecular mechanisms underlying pathological malfunction of gap junct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.07.081

    authors： Lee CY,Choi JW,Shin S,Lee J,Seo HH,Lim S,Lee S,Joo HC,Kim SW,Hwang KC

    更新日期：2017-09-16 00:00:00

  • The sequence of sites recognised by a member of the RNase E/G family can control the maximal rate of cleavage, while a 5'-monophosphorylated end appears to function cooperatively in mediating RNA binding.

    abstract：:Members of the RNase E/G family are multimeric, 5'-end-sensing, single-strand-specific endoribonucleases that are found in chloroplasts as well as bacteria, and have central roles in RNA processing and degradation. A well-studied member of this family is Escherichia coli RNase G. Recently, we have shown that the inter...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.11.156

    authors： Jourdan SS,Kime L,McDowall KJ

    更新日期：2010-01-01 00:00:00

  • Optical spectroscopic observation of a metastable form of sperm whale myoglobin generated by reconstitution.

    abstract：:The optical spectrum of Sperm Whale myoglobin, which has been freshly reconstituted with iron protoporphyrin-IX, is shown to be different from that obtained from the native myoglobin, and from the reconstituted, incubated myoglobin (These last two have equivalent absorption spectra). The effect is immediately evident ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91594-5

    authors： Gebe JA,Peyton DH,Peyton JA

    更新日期：1989-05-30 00:00:00

  • Differences in phospholipid incorporation of 32P relevant to alpha 1-receptor coupling events in rat and rabbit aorta.

    abstract：:Labelling of membrane phospholipids with 32P was compared in rat and rabbit aorta under basal conditions and during alpha 1-receptor stimulation. Incorporation of 32P proceeded at a significantly higher rate in rat tissue. The ratio of basal labelling following 30 min of incubation for rat/rabbit arteries was 4.8 for ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80174-7

    authors： Campbell MD,Danthuluri NR,Deth RC

    更新日期：1986-12-30 00:00:00