The mitogenic principle of Escherichia coli lipoprotein: B-lymphocyte mitogenicity of the synthetic analogue palmitoyl-tetrapeptide (Pam-Ser-Ser-Asn-Ala).

abstract：:The complex of immobilized human plasminogen (iHPlg) and streptokinase (SK) has a lower catalytic activity in hydrolysis of plasmin-specific substrate S-2251 with a kcat/Km of 0.005 microM-1 x s-1, compared to 0.031 microM-1 x s-1 of immobilized human plasmin (iHPlm) and 0.078 microM-1 x s-1 of HPlm. The SK in the com...

journal_title：Biochemical and biophysical research communications

authors： Shi GY,Chang BI,Wu DH,Wu HL

更新日期：1993-08-31 00:00:00

abstract：:The dopamine receptor D4 (DRD4) has received increasing research attention in behavioral science, psychiatry, and psychopharmacology. However, the number of available genetic markers for primates is still insufficient. We identified a novel variation/polymorphism in the second intron of DRD4 in humans based on the sur...

journal_title：Biochemical and biophysical research communications

authors： Shimada MK,Inoue-Murayama M,Ueda Y,Maejima M,Murayama Y,Takenaka O,Hayasaka I,Ito S

更新日期：2004-04-16 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:Inflammatory mediators and adhesion molecules have been implicated in a variety of diseases including atherosclerosis. As both the mediator-releasing and targeted cells, vascular endothelial cells play key role in pathological processes. NF-κB signaling regulates a cluster of inflammatory factors in LPS-activated vasc...

journal_title：Biochemical and biophysical research communications

authors： Yu S,Chen X,Xiu M,He F,Xing J,Min D,Guo F

更新日期：2017-03-25 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is periodically administered to immunocompromised patients together with antimicrobial agents. The evidence that supports the effectiveness of IVIG is mostly based on data from randomized clinical trials; the underlying mechanisms are poorly understood. A recent study revealed that ki...

journal_title：Biochemical and biophysical research communications

authors： Matsuo H,Itoh H,Kitamura N,Kamikubo Y,Higuchi T,Shiga S,Ichiyama S,Kondo T,Takaori-Kondo A,Adachi S

更新日期：2015-08-14 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that regulate the target gene expression. A change in miR profile in the pancreatic islets during diabetes is known, and multiple studies have demonstrated that miRs influence the pancreatic β-cell function. The miR-204 is highly expressed in the β-cells and reported to regul...

journal_title：Biochemical and biophysical research communications

authors： Gaddam RR,Kim YR,Li Q,Jacobs JS,Gabani M,Mishra A,Promes JA,Imai Y,Irani K,Vikram A

更新日期：2020-11-05 00:00:00

abstract：:Proteins with expanded polyglutamine domains cause eight inherited neurodegenerative diseases including Huntington's disease. In a previous paper, we identified peptides that inhibit polyglutamine protein aggregation and cell death and now describe the amino acid sequence requirements necessary for these activities. T...

journal_title：Biochemical and biophysical research communications

authors： Ren H,Nagai Y,Tucker T,Strittmatter WJ,Burke JR

更新日期：2001-11-02 00:00:00

abstract：:Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic n...

journal_title：Biochemical and biophysical research communications

authors： Ishizuka J,Beauchamp RD,Evers BM,Townsend CM Jr,Thompson JC

更新日期：1992-06-15 00:00:00

abstract：:Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect. Initially we found that triglyceride turnover was faster in hAPOA5 transgenic mice compared to controls, and this strongly correlated w...

journal_title：Biochemical and biophysical research communications

authors： Fruchart-Najib J,Baugé E,Niculescu LS,Pham T,Thomas B,Rommens C,Majd Z,Brewer B,Pennacchio LA,Fruchart JC

更新日期：2004-06-25 00:00:00

abstract：:Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregul...

journal_title：Biochemical and biophysical research communications

authors： Agostini M,Tucci P,Melino G

更新日期：2011-10-28 00:00:00

abstract：:ASC2 structure has been well defined by 1141 NOE experimental restraints. The model consists of five alpha helices. alpha-Helices are connected by short random structure loops. The sole exception is the loop connecting helices 2 and 3, which has a 20-residue length. Folding generally agrees with the folding of recentl...

journal_title：Biochemical and biophysical research communications

authors： Espejo F,Patarroyo ME

更新日期：2006-02-17 00:00:00

abstract：:Recombinant human glia maturation factor beta (r-hGMF-beta) is a single-chain polypeptide (141 amino acid residues) containing three cysteines, at positions 7, 86 and 95. Nascent r-hGMF-beta exists in the reduced state and has no biological activity. The protein can be activated through oxidative refolding by incubati...

journal_title：Biochemical and biophysical research communications

authors： Zaheer A,Lim R

更新日期：1990-09-14 00:00:00

abstract：:We examined exendin(9-39), an antagonist of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R), as a potential probe for imaging of pancreatic beta-cells. To evaluate in vitro receptor specificity, binding assay was performed using dispersed mouse islet cells. Binding assay showed competitive inhibition of [(125)I]BH-e...

journal_title：Biochemical and biophysical research communications

authors： Mukai E,Toyoda K,Kimura H,Kawashima H,Fujimoto H,Ueda M,Temma T,Hirao K,Nagakawa K,Saji H,Inagaki N

更新日期：2009-11-20 00:00:00

abstract：:We present the first direct biochemical evidence for the turnover of intact type VI collagen microfibrils. Matrix-degrading enzymes of the serine proteinase class, including rat mast cell chymases I and II, human mast cell tryptase, neutrophil elastase, cathepsin G and trypsin, were able to catabolize intact type VI c...

journal_title：Biochemical and biophysical research communications

authors： Kielty CM,Lees M,Shuttleworth CA,Woolley D

更新日期：1993-03-31 00:00:00

abstract：:The matrix metalloproteinases (MMPs) are a group of enzymes which have the ability to degrade extracellular matrix. They also cleave non-matrix proteins such as myelin basic protein and alpha 1-antitrypsin and they are able to process tumour necrosis factor-alpha (TNF) to its mature form. We have cloned, expressed and...

journal_title：Biochemical and biophysical research communications

authors： Chandler S,Cossins J,Lury J,Wells G

更新日期：1996-11-12 00:00:00

abstract：:The I domains of CD11 are responsible for the binding of ligands and have a unique structure with 6-7 alpha helices and 6 beta sheets with interconnecting loops. To determine loops recognizing fibrinogen in CD11c I domain, five oligopeptides corresponding to CD11c loops were used to prevent fibrinogen binding to isola...

journal_title：Biochemical and biophysical research communications

authors： Choi J,Nham SU

更新日期：2002-04-05 00:00:00

abstract：:Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1alpha subunit of the pyruvate dehydrogenase complex (PDC). Sequence analysis of cloned PDKs led to the proposal that they are mechanistically related to prokaryotic 2-component His-kinases. The reaction mechanism of protein His-kinases involves auto...

journal_title：Biochemical and biophysical research communications

authors： Mooney BP,David NR,Thelen JJ,Miernyk JA,Randall DD

更新日期：2000-01-19 00:00:00

abstract：:Epidemiological and experimental data suggest a role for polyunsaturated fatty acids in the etiology of breast cancer. In this report we have studied arachidonic acid and linoleic acid metabolism in the human breast carcinoma cell line BT-20 which overexpresses both EGF receptor and the homologous erbB-2 oncogene prod...

journal_title：Biochemical and biophysical research communications

authors： Reddy N,Everhart A,Eling T,Glasgow W

更新日期：1997-02-03 00:00:00

abstract：:Enhancer sequences analysed using the informational spectrum method (ISM) show a characteristic frequency at .0488. It has been shown that the characteristic frequency for some DNA binding proteins overlaps the characteristic frequency of their target DNA sequences. We suggest here that two types of proteins, homeopro...

journal_title：Biochemical and biophysical research communications

authors： Cosić I,Nesić D,Pavlović M,Williams R

更新日期：1986-12-15 00:00:00

abstract：:Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ...

journal_title：Biochemical and biophysical research communications

authors： Wictome M,Holub M,East JM,Lee AG

更新日期：1994-03-15 00:00:00

abstract：:EcoP1I methyltransferase (M.EcoP1I) belongs to the type III restriction-modification system encoded by prophage P1 that infects Escherichia coli. Binding of M.EcoP1I to double-stranded DNA and single-stranded DNA has been characterized. Binding to both single- and double-stranded DNA could be competed out by unlabeled...

journal_title：Biochemical and biophysical research communications

authors： Sistla S,Krishnamurthy V,Rao DN

更新日期：2004-01-30 00:00:00

abstract：:Specific receptors for murine TNF have been identified in homogenates of rodent brain. These receptors are saturable and bind TNF with sufficient affinity to ensure occupancy by cytokine elaborated during infection. 125I-mTNF was detected in four specific complexes of Mr 130,000, 90,000, 66,000 and 60,000 after affini...

journal_title：Biochemical and biophysical research communications

authors： Kinouchi K,Brown G,Pasternak G,Donner DB

更新日期：1991-12-31 00:00:00

abstract：:We previously reported that fucoidan, a dietary fiber purified from seaweed, inhibited IgE production by B cells in vitro. In this study, we examined the effect of fucoidan on IgE production in vivo. The OVA-induced increase of plasma IgE was significantly suppressed when fucoidan was intraperitoneally, but not orally...

journal_title：Biochemical and biophysical research communications

authors： Yanase Y,Hiragun T,Uchida K,Ishii K,Oomizu S,Suzuki H,Mihara S,Iwamoto K,Matsuo H,Onishi N,Kameyoshi Y,Hide M

更新日期：2009-09-25 00:00:00

abstract：:To clarify the presence of thromboxane A2 (TXA2) receptor in the colonic epithelium, we examined the effect of 9,11-epithio-11, 12-methano-thromboxane A2 (STA2), a stable analogue of TXA2, on intracellular free Ca2+ concentration ([Ca2+]i) of indo-1-loaded single cells in isolated rat colonic crypts by laser confocal ...

journal_title：Biochemical and biophysical research communications

authors： Ikari A,Sakai H,Sato T,Takeguchi N

更新日期：1999-05-19 00:00:00

abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Chen X,Zhang M,Luo Z

更新日期：2020-03-26 00:00:00

abstract：:TonEBP/NFAT5 transcription factor is a master regulator of genes involved in osmoprotection. Cyclooxygenase 2 (COX2) has been reported to be a cytoprotective molecule in the inner renal medulla, where cells are physiologically exposed to the highest osmolality of the body. Our aim was to study whether COX2 expression ...

journal_title：Biochemical and biophysical research communications

authors： Favale NO,Casali CI,Lepera LG,Pescio LG,Fernández-Tome MC

更新日期：2009-04-10 00:00:00

abstract：:Ceramide kinase (CERK) converts ceramide to ceramide-1-phosphate (C1P), which has recently emerged as a new bioactive molecule capable of regulating diverse cellular functions. The N-terminus of the CERK protein encompasses a sequence motif known as a pleckstrin homology (PH) domain. Although the PH domain was previou...

journal_title：Biochemical and biophysical research communications

authors： Kim TJ,Mitsutake S,Igarashi Y

更新日期：2006-04-07 00:00:00

abstract：:Monoclonal antibody BB1 was previously shown to recognize the CD80 protein as well as a putative B7.3 molecule, both ligands of the important T-cell receptors CD28 and CTLA-4. We report that BB1 coprecipitated from detergent lysates of human B- and pre-B-cell lines a protein kinase activity, as detected by solid phase...

journal_title：Biochemical and biophysical research communications

authors： Angelisová P,Cerný J,Horejsí V

更新日期：1996-11-12 00:00:00

abstract：:Liposomes containing the expression vector pRSVneo coding for neomycin phosphotransferase-II were used for a gene transfer into rat liver cells in vivo. After intravenous application of liposomes to male Wistar-rats, non-integrated vector DNA was detected by blot-hybridisation in isolated nuclei of hepatocytes. Presen...

journal_title：Biochemical and biophysical research communications

authors： Leibiger B,Leibiger I,Sarrach D,Zühlke H

更新日期：1991-02-14 00:00:00

abstract：:Two proteins (25- and 22-kDa) that cross-react with anti-gizzard SM22 alpha antibody were isolated from bovine aorta. The former, identical to a SM22 alpha homolog reported previously (Kobayashi, R., Kubota, T., and Hidaka, H. (1994) Biochem. Biophys. Res. Commun. 198, 1275-1280), associates with the membrane fraction...

journal_title：Biochemical and biophysical research communications

authors： Shishibori T,Yamashita K,Bandoh J,Oyama Y,Kobayashi R

更新日期：1996-12-04 00:00:00