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Polymorphism in the second intron of dopamine receptor D4 gene in humans and apes.

Abstract：

:The dopamine receptor D4 (DRD4) has received increasing research attention in behavioral science, psychiatry, and psychopharmacology. However, the number of available genetic markers for primates is still insufficient. We identified a novel variation/polymorphism in the second intron of DRD4 in humans based on the survey of 210 Japanese: a 6bp insertion (allele frequency: 0.002) and 8bp deletion (0.024); however, 94 Hungarian Caucasians were found to be monomorphic. Polymorphisms of the homologous region were also found in a survey of 93 specimens from four species of great apes and 51 specimens from seven species of gibbons. The polymorphisms consist of both single nucleotide substitutions and variations in the number of tandem duplications of short GC-rich sequences. Because of usefulness of primates in behavioral science, this polymorphism may be a useful marker for association studies with behavioral traits in both humans and apes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shimada MK,Inoue-Murayama M,Ueda Y,Maejima M,Murayama Y,Takenaka O,Hayasaka I,Ito S

doi

10.1016/j.bbrc.2004.03.006

subject

Has Abstract

pub_date

2004-04-16 00:00:00

pages

1186-90

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X04004838

journal_volume

316

pub_type

杂志文章

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