Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.

abstract：:The collagenase from the larvae Hypoderma lineatum is a serine proteinase sequentially related to the trypsin family. The tryptic peptide containing the serine residue of the active site, labelled with [3H] diisopropylfluorophosphate was isolated and determined to be Ser-Pro-Cys-Phe-Gly-Asp-Ser-Gly-Gly-Pro-(Phe-Ser)-L...

journal_title：Biochemical and biophysical research communications

authors： Lecroisey A,Keil B

更新日期：1983-05-16 00:00:00

abstract：:In RNA, function follows form. Mapping the surface of RNA molecules with chemical and enzymatic probes has revealed invaluable information about structure and folding. Hydroxyl radicals ((·)OH) map the surface of nucleic acids by cutting the backbone where it is accessible to solvent. Recent studies showed that a micr...

journal_title：Biochemical and biophysical research communications

authors： Schlatterer JC,Wieder MS,Jones CD,Pollack L,Brenowitz M

更新日期：2012-08-24 00:00:00

abstract：:We previously identified the novel gene, periodontal ligament-associated protein-1 (PLAP-1)/asporin and reported that PLAP-1/asporin inhibited bone morphogenetic protein-2 (BMP-2)-induced cytodifferentiation of periodontal ligament (PDL) cells probably by direct interaction with BMP-2. Here, we elucidated the detailed...

journal_title：Biochemical and biophysical research communications

authors： Tomoeda M,Yamada S,Shirai H,Ozawa Y,Yanagita M,Murakami S

更新日期：2008-06-27 00:00:00

abstract：:It has been suggested that the positive inotropic effect of the vasoactive peptide hormone, endothelin-1 (ET-1), involves inhibition of cardiac K(+) currents. In order to identify the K(+) currents modulated by ET-1, the outward K(+) currents of isolated rat ventricular myocytes were investigated using whole-cell patc...

journal_title：Biochemical and biophysical research communications

authors： James AF,Ramsey JE,Reynolds AM,Hendry BM,Shattock MJ

更新日期：2001-06-22 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the causal gene for autosomal dominant familial Parkinson's disease. We have previously reported a novel molecular feature characteristic to I2020T mutant LRRK2: higher susceptibility to post-translational degradation than the wild-type LRRK2. In the present study, we demonstrat...

journal_title：Biochemical and biophysical research communications

authors： Ohta E,Kubo M,Obata F

更新日期：2010-01-01 00:00:00

abstract：:Infection with the highly pathogenic avian influenza H5N1 virus results in a high incidence of mortality in humans. Severe complications from infection are often associated with hypercytokinemia. However, current neuraminidase inhibitors (NAIs) have several limitations including the appearance of oseltamivir-resistant...

journal_title：Biochemical and biophysical research communications

authors： Cho J,Yi H,Jang EY,Lee MS,Lee JY,Kang C,Lee CH,Kim K

更新日期：2017-12-09 00:00:00

abstract：:Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline)...

journal_title：Biochemical and biophysical research communications

authors： Lopes JC,Botelho FV,Barbosa Silva MJ,Silva SF,Polloni L,Alves Machado PH,Rodrigues de Souza T,Goulart LR,Silva Caldeira PP,Pereira Maia EC,Morelli S,de Oliveira-Júnior RJ

更新日期：2020-12-17 00:00:00

abstract：:GPR109A (PUMA-G, NIACR1, HCA(2)) and GPR81 (HCA(1)) are G protein-coupled receptors located predominantly on adipocytes that mediate anti-lipolytic effects. These cell surface receptors give the adipocyte the ability to "sense" metabolic changes in the environment and respond through lipolytic regulation and release o...

journal_title：Biochemical and biophysical research communications

authors： Wanders D,Graff EC,Judd RL

更新日期：2012-08-24 00:00:00

abstract：:In this study, an endogenous factor(s) involved in the suppression of the induction of CYP1A1 was studied. Analyzing the sequences, we found that the sequence of xenobiotic responsive element (XRE) in the upstream region of the human CYP1A1 gene was overlapped with that of the upstream stimulatory factor 1 (USF1)-bind...

journal_title：Biochemical and biophysical research communications

authors： Takahashi Y,Nakayama K,Itoh S,Kamataki T

更新日期：1997-11-17 00:00:00

abstract：:Bone Morphogenetic Proteins (BMPs) strongly induce the recruitment and differentiation of mesenchymal progenitor cells into mature osteoblasts, but also directly and indirectly stimulate differentiation of osteoclast progenitor cells and acceleration of mature osteoclasts function leading excessive bone resorption. Bi...

journal_title：Biochemical and biophysical research communications

authors： Ichikawa K,Ohta Y,Mamoto K,Mizokawa S,Minoda Y,Imai Y,Takaoka K,Nakamura H

更新日期：2016-11-18 00:00:00

abstract：:We find that the low frequency Raman spectrum of Zn(II) metallothionein has a single prominent band at 138 cm-1 which is absent from the Raman spectrum of the metal-free protein. This feature is also found for Cd(II) binding to both of the independent metallothionein domains and the metallothionein from Neurospora cra...

journal_title：Biochemical and biophysical research communications

authors： Elgren TE,Wilcox DE

更新日期：1989-09-15 00:00:00

abstract：:Porcine kidney betaine aldehyde dehydrogenase (EC 1.2.1.8) kinetic properties were determined at low substrate concentrations. The double-reciprocal plots of initial velocity versus substrate concentration are linear and intersect at the left of the 1/v axis and showed substrate inhibition with betaine aldehyde. Studi...

journal_title：Biochemical and biophysical research communications

authors： Figueroa-Soto CG,Valenzuela-Soto EM

更新日期：2000-03-16 00:00:00

abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

journal_title：Biochemical and biophysical research communications

authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

更新日期：1992-10-15 00:00:00

abstract：:The human MEP1A gene encodes the meprin alpha subunit that consists of a protease domain conserved in the astacin family of metalloendopeptidases and several C-terminal interaction domains present in other proteins. Using the alpha subunit cDNA, we identified two clones from a human P1-derived artificial chromosome (P...

journal_title：Biochemical and biophysical research communications

authors： Jiang W,Beatty BG

更新日期：1999-07-22 00:00:00

abstract：:A rat gene with testis-specific expression coinciding with spermatogenesis was cloned by differential display. This spermatogenesis-related factor-1 (SRF-1) gene was not expressed in other organs. Testicular expression was detected from 5 weeks of age and increased up to 15 weeks; this level of expression was maintain...

journal_title：Biochemical and biophysical research communications

authors： Yamano Y,Ohyama K,Sano T,Ohta M,Shimada A,Hirakawa Y,Sugimoto M,Morishima I

更新日期：2001-12-14 00:00:00

abstract：:In this paper, we investigated the subcellular distribution of p190rho guanosine triphosphatase-activating protein (p190 GAP) in human neutrophils stimulated with different agonists. The results show that in neutrophils treated with formyl-methionyl-leucyl-phenylalanine (FMLP) (1) p190 GAP was translocated from the cy...

journal_title：Biochemical and biophysical research communications

authors： Dusi S,Donini M,Wientjes F,Rossi F

更新日期：1996-02-27 00:00:00

abstract：:Arginine-rich cell-penetrating peptides (CPPs) are promising carriers for the intracellular delivery of various bioactive molecules. However, many ambiguities remain about the molecular interplays on cell surfaces that ultimately lead to endocytic uptake of CPPs. By treatment of cells with octaarginine (R8), enhanced ...

journal_title：Biochemical and biophysical research communications

authors： Nakase I,Osaki K,Tanaka G,Utani A,Futaki S

更新日期：2014-04-18 00:00:00

abstract：:The first life forms evolved in a highly reducing environment. This reduced state is still carried by cells today, which makes the concept of "reductive stress" somewhat redundant. When oxygen became abundant on the Earth, due to the evolution of photosynthesis, life forms had to adapt or become extinct. Living organi...

journal_title：Biochemical and biophysical research communications

authors： Gutteridge JMC,Halliwell B

更新日期：2018-07-12 00:00:00

abstract：:p70 S6 kinase (p70 S6k) is important in regulating a variety of cellular functions including mRNA translation and cell cycle progression and is activated by mitogens and hormones. Unexpectedly, we have found that, in adult rat cardiomyocytes, arsenite, which generally induces stress responses, markedly and rapidly act...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Proud CG

更新日期：1997-09-08 00:00:00

abstract：:Using a monospecific antibody to the major cytosolic glutathione-S-transferase of human liver, we have isolated a cDNA clone from a human liver cDNA expression vector library in lambda gt11. The clone cross-hybridizes with a rat liver ligandin (glutathione-S-transferase 1-2) cDNA probe. The clone has an insert of 1.25...

journal_title：Biochemical and biophysical research communications

authors： Butera L,Monnier JR,Campbell E,Bhargava MM

更新日期：1987-02-13 00:00:00

abstract：:CD36 expressed on adipocytes is thought to function as a fatty acid transporter (FAT). Here we report that adipocytes can endocytose and lysosomally degrade OxLDL, mainly mediated by CD36. Mouse 3T3-L1 preadipocytes showed marked increase in uptake and degradation of (125)I-OxLDL during their differentiation to adipoc...

journal_title：Biochemical and biophysical research communications

authors： Kuniyasu A,Hayashi S,Nakayama H

更新日期：2002-07-12 00:00:00

abstract：:A chemical inhibitor library of 84 compounds was screened to investigate the signaling pathway(s) leading to activation of Nrf2 in response to nitric oxide (NO). We identified the protein kinase C delta (PKCdelta) inhibitor rottlerin as the only compound that reduced NO-induced ARE-luciferase reporter activity and dim...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Hung AC,Ng PY,Nakayama K,Hu Y,Li B,Porter AG,Dhakshinamoorthy S

更新日期：2009-09-04 00:00:00

abstract：:We demonstrated lanthionine introduction into hexa-histidine-tagged (His-tagged) nukacin ISK-1 prepeptide NukA by modification enzyme NukM in Escherichia coli. Co-expression of nukA and nukM, purification of the resulting His-tagged prepeptide by affinity chromatography, and subsequent mass spectrometry analysis showe...

journal_title：Biochemical and biophysical research communications

authors： Nagao J,Harada Y,Shioya K,Aso Y,Zendo T,Nakayama J,Sonomoto K

更新日期：2005-10-21 00:00:00

abstract：:Recent years have seen considerable evolution in our understanding of the mechanisms of oxygen activation by non-heme iron enzymes, with high-valent iron-oxo intermediates coming to the forefront as formidably potent oxidants. In the absence of substrate, the generation of vividly colored chromophores deriving from th...

journal_title：Biochemical and biophysical research communications

authors： Farquhar ER,Koehntop KD,Emerson JP,Que L Jr

更新日期：2005-12-09 00:00:00

abstract：:Vascular degeneration appears to play crucial roles in producing many vascular malfunctions (1-3). In order to identify specific inducers of programmed death in vascular endothelial cells (VEC), examinations were made of the effects of substances that are known to affect the vascular system by using VEC in culture (4,...

journal_title：Biochemical and biophysical research communications

authors： Araki S,Ishida T,Yamamoto T,Kaji K,Hayashi H

更新日期：1993-01-15 00:00:00

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 × JF1 mice and RNA-seq analysis identified Hcn1 gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 1...

journal_title：Biochemical and biophysical research communications

authors： Akbor MM,Tomobe K,Yamada T,Kim J,Mano H,Kurosawa N,Sasaki K,Nomura Y,Isobe M

更新日期：2013-11-08 00:00:00

abstract：:Calmodulin (CaM) plays a crucial role in metabolism and physiology of eukaryotes by regulating biological activities. Multiple lines of evidences indicate that the phosphorylated flavonoids possess relatively stronger affinities for proteins by forming non-covalent complexes with them, and that the cellular functions ...

journal_title：Biochemical and biophysical research communications

authors： Li L,Wei DQ,Wang JF,Chou KC

更新日期：2007-07-13 00:00:00

abstract：:The alpha-ketoglutarate dehydrogenase complex of Escherichia coli can bind up to 12 dimers of dihydrolipoyl dehydrogenase (E3) besides those already present. Maximal activity does not increase, however, when surplus E3 is present. This observation was previously interpreted to mean that the excess enzyme is inactive. ...

journal_title：Biochemical and biophysical research communications

authors： Wagenknecht T,Francis N,DeRosier D

更新日期：1986-03-28 00:00:00

abstract：:Epigenetic modifications such as DNA methylation and histone H3 lysine 27 methylation (H3K27me) are repressive marks that silence gene expression. The M phase phosphoprotein (MPP8) associates with proteins involved in both DNA methylation and histone modifications, and therefore, is a potential candidate to mediate cr...

journal_title：Biochemical and biophysical research communications

authors： Murata K,Sato S,Haruta M,Goshima T,Chiba Y,Takahashi S,Sharif J,Koseki H,Nakanishi M,Shimada M

更新日期：2015-03-13 00:00:00

abstract：:Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 has been shown to regulate Beclin1 and Beclin1-dependent autophagy in embryonic stem cells and cancer cells. However, whether Ambra1 plays an important role in the autoph...

journal_title：Biochemical and biophysical research communications

authors： Shi C,Wu J,Fu M,Zhang B,Wang J,Yang X,Chi Y

更新日期：2014-09-26 00:00:00