当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > In vitro and in vivo antitumoral activity of a ternary copper (II) complex.

In vitro and in vivo antitumoral activity of a ternary copper (II) complex.

Abstract：

:Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline) complex [Cu(dox)(phen)]2+ was especially designed as an antitumoral drug, previously showing high cytotoxicity and DNA cleavage activity. We aimed to further investigate the in vitro cytotoxic activity in both tumoral and non-tumoral cells, in vitro genotoxic potential, and in vivo antitumor activity using BALB/C mouse injected with sarcoma S180 and Ehrlich cell lines. Our results indicated that this compound exhibits a moderate genotoxic potential, with selective growth inhibition of tumor cells, especially the murine melanoma B16F10. Its main mechanism of action seems to be through ROS generation. We have further shown a significant reduction of the implanted tumor size in the animal model, suggesting that this compound has great antitumoral potential against many tumor types. [Cu(dox)(phen)]2+ is selectively cytotoxic for melanoma B16F10 and showed high chemotherapeutic potential in vivo against implanted sarcoma S180 and Ehrlich ascites tumours.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lopes JC,Botelho FV,Barbosa Silva MJ,Silva SF,Polloni L,Alves Machado PH,Rodrigues de Souza T,Goulart LR,Silva Caldeira PP,Pereira Maia EC,Morelli S,de Oliveira-Júnior RJ

doi

10.1016/j.bbrc.2020.09.104

subject

Has Abstract

pub_date

2020-12-17 00:00:00

pages

1021-1026

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)31858-1

journal_volume

533

pub_type

杂志文章

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