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Antibodies against the N-terminus of IL-8 receptor A inhibit neutrophil chemotaxis.

Abstract：

:Neutrophil migration and activation are the cornerstones of the acute inflammatory response. Interleukin-8 triggers several functions of neutrophils in host defense: chemotaxis, degranulation and enzyme release, and superoxide production. Interleukin-8 is most potent as a chemoattractant, so chemotaxis is likely the most important of these functions. The effects of interleukin-8 on neutrophils are mediated through two receptors, IL-8RA and IL-8RB. To investigate the role of these receptors in neutrophil chemotaxis, we produced inhibitory antibodies to IL-8RA. These antibodies inhibit neutrophil chemotaxis toward IL-8 in vitro. These findings show that IL-8RA mediates a chemotactic signal in neutrophils and suggest that an anti-receptor strategy may be a useful approach to limit neutrophil migration in inflammation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Quan JM,Martin TR,Rosenberg GB,Foster DC,Whitmore T,Goodman RB

doi

10.1006/bbrc.1996.0246

subject

Has Abstract

pub_date

1996-02-15 00:00:00

pages

405-11

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90246-6

journal_volume

219

pub_type

杂志文章

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