TGF-beta 1 modulated the expression of alpha 5 beta 1 integrin and integrin-mediated signaling in human hepatocarcinoma cells.

abstract：:TMEM1 (EHOC-1) gene encodes a putative transmembrane protein and is located on human chromosome band 21q22.3. Analysis of a 122,638-bp genomic sequence revealed that TMEM1 gene consists of 23 exons spanning approximately 94 kb and is transcribed in the direction of centromere to telomere. The 5' region of the TMEM1 ge...

journal_title：Biochemical and biophysical research communications

authors： Nagamine K,Kudoh J,Kawasaki K,Minoshima S,Asakawa S,Ito F,Shimizu N

更新日期：1997-06-09 00:00:00

abstract：:This study examined whether oral administration of an arginase inhibitor regulates adipose tissue macrophage infiltration and inflammation in mice with high fat diet (HFD)-induced obesity. Male C57BL/6 mice (n = 30) were randomly assigned to control (CTL, n = 10), HFD only (n = 10), and HFD with arginase inhibitor N(ω...

journal_title：Biochemical and biophysical research communications

authors： Hu H,Moon J,Chung JH,Kim OY,Yu R,Shin MJ

更新日期：2015-08-28 00:00:00

abstract：:Abnormal plasma ascorbic acid (AA) and dehydroascorbic acid (DHAA) levels observed in diabetes may be correlated to a deficiency in the recycling of AA. Ascorbic acid and DHAA levels are altered in diabetic liver in the present study. In addition, a coupling of the hexose monophosphate (HMP) shunt by way of NADPH to g...

journal_title：Biochemical and biophysical research communications

authors： Bode AM,Yavarow CR,Fry DA,Vargas T

更新日期：1993-03-31 00:00:00

abstract：:Surfactant convertase is required for conversion of heavy density (H) natural surfactant to light density (L) subtype during cycling in vitro, a technique that reproduces surfactant metabolism. To study mechanisms of H to L conversion, we prepared liposomes of dipalmitoylphosphatidylcholine (DPPC) and phosphatidylglyc...

journal_title：Biochemical and biophysical research communications

authors： Dhand R,Sharma VK,Teng AL,Krishnasamy S,Gross NJ

更新日期：1998-03-27 00:00:00

abstract：:Glycosyl-phosphatidylinositol (GPI) anchored proteins are surveyed in two insulin sensitive cell types by surface labeling and phospholipase C-induced release into the medium. Serum starvation selectively increases both the number and intensity of a subset of GPI-anchored proteins. After serum starvation, loss of cell...

journal_title：Biochemical and biophysical research communications

authors： Lisanti MP,Darnell JC,Chan BL,Rodriguez-Boulan E,Saltiel AR

更新日期：1989-10-31 00:00:00

abstract：:This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the chronic inflammatory state commonly found with painful IDD. Pro-inflammatory cytoki...

journal_title：Biochemical and biophysical research communications

authors： Purmessur D,Walter BA,Roughley PJ,Laudier DM,Hecht AC,Iatridis J

更新日期：2013-03-29 00:00:00

abstract：:In this study the interactions of oxytocin with the transmembrane region of the oxytocin receptor were modelled in order to explain the selective binding of oxytocin and vasopressin. Three sites of interaction in the receptors were identified by sequence comparison and model building. Both receptors share one site, wh...

journal_title：Biochemical and biophysical research communications

authors： Hakala JM

更新日期：1994-08-15 00:00:00

abstract：:PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and...

journal_title：Biochemical and biophysical research communications

authors： Kozlov G,Perreault A,Schrag JD,Park M,Cygler M,Gehring K,Ekiel I

更新日期：2004-08-13 00:00:00

abstract：:HMGB proteins are abundant, non-histone proteins in eukaryotic chromatin. HMGB proteins contain one or two conserved "HMG boxes" and can be sequence-specific or nonspecific in their DNA binding. HMGB proteins cause strong DNA bending and bind preferentially to deformed DNAs. We wish to understand how HMGB proteins inc...

journal_title：Biochemical and biophysical research communications

authors： Zimmerman J,Maher LJ 3rd

更新日期：2008-06-20 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) glycoprotein E (gE) is a multifunctional protein capable of both binding the Fc portion of IgG and mediating cell-to-cell spread of HSV-1. Here we report that the domain on gE involved in IgG binding is distinct from the domain involved in mediating cell-to-cell spread. To do this we hav...

journal_title：Biochemical and biophysical research communications

authors： Weeks BS,Sundaresan P,Nagashunmugam T,Kang E,Friedman HM

更新日期：1997-06-09 00:00:00

abstract：:The involvement of vitamin D in prostate carcinogenesis was investigated using the human prostatic LNCaP cells. Incubation of the LNCaP with 100 nM 1 alpha,25-dihydroxyvitamin D3 for 2 days resulted in a 30-40% suppression of cell growth, which was accompanied by a greater than 70% down-regulated expression of the pro...

journal_title：Biochemical and biophysical research communications

authors： Hsieh TY,Ng CY,Mallouh C,Tazaki H,Wu JM

更新日期：1996-06-05 00:00:00

abstract：:Glycine-rich RNA-binding proteins play an important role in post-transcriptional regulation of gene expression, including RNA processing, and are known to be up-regulated in response to a number of external stimuli. However, their regulation in response to salinity stress has not been reported. We have isolated a ligh...

journal_title：Biochemical and biophysical research communications

authors： Aneeta,Sanan-Mishra N,Tuteja N,Kumar Sopory S

更新日期：2002-09-06 00:00:00

abstract：:A well-established feature of the translation initiation region, which attracts the ribosomes to the prokaryotic mRNAs, is a purine rich area called Shine/Dalgarno sequence (SD). There are examples of various other sequences, which despite having no similarity to an SD sequence are capable of enhancing and/or initiati...

journal_title：Biochemical and biophysical research communications

authors： Golshani A,Krogan NJ,Xu J,Pacal M,Yang XC,Ivanov I,Providenti MA,Ganoza MC,Ivanov IG,AbouHaidar MG

更新日期：2004-04-16 00:00:00

abstract：:Cancer-induced pain (CIP) is a kind of chronic pain that occurs during cancer progression over time. However, the mechanisms are largely unknown, and clinical treatment remains challenging. LncRNAs have been reported to play critical roles in various biological processes, including chronic pain. The aim of our study w...

journal_title：Biochemical and biophysical research communications

authors： Sun RM,Wei J,Wang SS,Xu GY,Jiang GQ

更新日期：2020-04-16 00:00:00

abstract：:To investigate the role of the carboxyl group in deltorphin molecules, we have synthesized three new analogues in which the acidic amino acid residues in position 4 of the deltorphins were replaced by non-acidic but hydrophilic amino acids residues. The three analogues, [Ser4]-, [Gln4]-, and [Cys4]-deltorphin, all are...

journal_title：Biochemical and biophysical research communications

authors： Misicka A,Lipkowski AW,Fang L,Knapp RJ,Davis P,Kramer T,Burks TF,Yamamura HI,Carr DB,Hruby VJ

更新日期：1991-11-14 00:00:00

abstract：:MicroRNA (miRNA)-mediated gene silencing has recently emerged as a major mechanism of gene expression regulation during development in a variety of species. Little is known, however, about the presence of components of miRNA machinery in mammalian organogenesis. In this study, we report that members of the Argonaute (...

journal_title：Biochemical and biophysical research communications

authors： Lü J,Qian J,Chen F,Tang X,Li C,Cardoso WV

更新日期：2005-08-26 00:00:00

abstract：:Autophagy has been implicated in several neurodegenerative diseases and recently its role in acute brain injury has received increased interest. In our study, we investigated the profiles of autophagy-linked proteins (MAP-LC3 (Atg8), beclin-1 (Atg6) and the beclin-1-binding protein, bcl-2, following controlled cortica...

journal_title：Biochemical and biophysical research communications

authors： Sadasivan S,Dunn WA Jr,Hayes RL,Wang KK

更新日期：2008-09-05 00:00:00

abstract：:BET inhibitors (BETi) exert an excellent anti-cancer activity in breast cancer. However, the identification of new potential targets to enhance breast cancer sensitivity to BETi is still an enormous challenge. Both NR5A2 and NCOA3 are frequently involved in cancer cells resistance to chemotherapy, also associated with...

journal_title：Biochemical and biophysical research communications

authors： Qiao J,Chen Y,Mi Y,Jin H,Huang T,Liu L,Gong L,Wang L,Wang Q,Zou Z

更新日期：2020-09-17 00:00:00

abstract：:To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions. One of these, D88, covers residues 1-88 and represents almost the entire headpiece; the othe...

journal_title：Biochemical and biophysical research communications

authors： Saeed T,Ip W

更新日期：1989-12-29 00:00:00

abstract：:Baculovirus p35 belongs to the early class of genes of AcMNPV and requires viral factors like Immediate Early protein-1 for its transcription. To investigate the role of host factors in regulating p35 gene expression, the putative transcription factor binding sites were examined in silico and the role of these factors...

journal_title：Biochemical and biophysical research communications

authors： Mohareer K,Sahdev S,Hasnain SE

更新日期：2011-11-04 00:00:00

abstract：:Adsorption of phage T4 to its outer membrane receptor (the lipopolysaccharide) triggers a transient depolarization of the cytoplasmic membrane which is prevented upon addition of EGTA, suggesting that calcium is necessary for the transmission of the signal between the two membranes. Using the fluorescent indicator QUI...

journal_title：Biochemical and biophysical research communications

authors： Boulanger P,Labedan B,Letellier L

更新日期：1985-09-16 00:00:00

abstract：:The close association of inflammation, angiogenesis and cancer progression is now highlighted, and in this study we especially focused on a close association of inflammation and lymphangiogenesis. We found that proinflammatory cytokine, interleukin-1beta (IL-1beta), could induce lymphangiogenesis in mouse cornea throu...

journal_title：Biochemical and biophysical research communications

authors： Watari K,Nakao S,Fotovati A,Basaki Y,Hosoi F,Bereczky B,Higuchi R,Miyamoto T,Kuwano M,Ono M

更新日期：2008-12-19 00:00:00

abstract：:Podocytes are the major site of vascular endothelial growth factor (VEGF) production in the kidney, and up-regulation of VEGF plays a critical role in the progression of diabetic nephropathy. Using a differentiated mouse podocyte cell line, we investigated the roles of protein kinase C (PKC) and extracellular signal-r...

journal_title：Biochemical and biophysical research communications

authors： Hoshi S,Nomoto K,Kuromitsu J,Tomari S,Nagata M

更新日期：2002-01-11 00:00:00

abstract：:An inhibitor of reverse transcriptase of Moloney leukemia virus was reported previously in the cytoplasm of the cultured cells (1). In this report, the mechanism of the inhibition was examined. The inhibitory activity was completely abrogated by treatment at 55 degrees C for 20 min. Destruction of the reaction product...

journal_title：Biochemical and biophysical research communications

authors： Rokutanda M,Watanabe ST,Maeda YY

更新日期：1984-08-30 00:00:00

abstract：:The development of rational methods to design 'continuous' sequence mimetics of discontinuous regions of protein sequence has, to now, been only marginally successful. This has been largely due to the difficulty of constraining the recognition elements of a mimetic structure to the relative conformational and spatial ...

journal_title：Biochemical and biophysical research communications

authors： Casset F,Roux F,Mouchet P,Bes C,Chardes T,Granier C,Mani JC,Pugnière M,Laune D,Pau B,Kaczorek M,Lahana R,Rees A

更新日期：2003-07-18 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an endothelial cell specific mitogen that induces angiogenesis in several pathological conditions. To block angiogenesis, soluble VEGF receptor can be used. In this study, we describe a method for high yield expression of soluble VEGF receptor 2 (sFlk-1) in a baculovirus ex...

journal_title：Biochemical and biophysical research communications

authors： Huang X,Gottstein C,Brekken RA,Thorpe PE

更新日期：1998-11-27 00:00:00

abstract：:The carboxyl terminus of the type 1 angiotensin II receptor (AT(1)) plays an important role in receptor phosphorylation, desensitization, and internalization. The yeast two-hybrid system was employed to isolate proteins associated with the carboxyl terminal region of the AT(1A) receptor. In the present study, we repor...

journal_title：Biochemical and biophysical research communications

authors： Guo DF,Chenier I,Tardif V,Orlov SN,Inagami T

更新日期：2003-10-31 00:00:00

abstract：:The fluorescence decay of adenosine in 1:1 glycol/water glass has been determined at 77K using narrow pulse (700 ps) laser excitation at 290 nm and fluorescence detection with a scanned narrow-gate (100 ps) fast sampler together with digital averaging. Data analysis by re-iterative non-linear least squares convolution...

journal_title：Biochemical and biophysical research communications

authors： Hart LP,Daniels M

更新日期：1989-07-31 00:00:00

abstract：:Valine-to-isoleucine substitution at codon 180 of the prion protein gene is only observed in patients with Creutzfeldt-Jakob disease and accounts for approximately half of all cases of genetic prion disease in Japan. In the present study, we investigated the biochemical characteristics of valine-to-isoleucine substitu...

journal_title：Biochemical and biophysical research communications

authors： Ito Y,Sanjo N,Hizume M,Kobayashi A,Ohgami T,Satoh K,Hamaguchi T,Yamada M,Kitamoto T,Mizusawa H,Yokota T

更新日期：2018-02-19 00:00:00

abstract：:Virus infection triggers innate responses to host cells including production of type I interferon (IFN). Since IFN production is also induced by treatment with poly(I:C), viral double-stranded (ds) RNA has been postulated to play a direct role in the process. In the present study, we investigated the effect of dsRNA b...

journal_title：Biochemical and biophysical research communications

authors： Iwamura T,Yoneyama M,Koizumi N,Okabe Y,Namiki H,Samuel CE,Fujita T

更新日期：2001-03-30 00:00:00