Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation.

abstract：:Difluoromethylornithine (DFMO) depletes cells of polyamines, sensitizing cells against the action of antineoplastic drugs and altering ability to repair radiation-induced DNA strand breaks. Others have hypothesized that the mechanism by which polyamine depletion sensitizes cells is through inhibition of DNA strand bre...

journal_title：Biochemical and biophysical research communications

authors： Williams JR,Casero RA,Dillehay LE

更新日期：1994-05-30 00:00:00

abstract：:We earlier reported the mitogenic and immunostimulatory activities of Rhizoctonia bataticola lectin (RBL), purified from phytopathogenic fungus R. bataticola in human PBMC. The lectin demonstrates specificity towards glycoproteins containing complex N-glycans. Since CD45-protein tyrosine phosphatase that abundantly ex...

journal_title：Biochemical and biophysical research communications

authors： Pujari R,Eligar SM,Kumar N,Nagre NN,Inamdar SR,Swamy BM,Shastry P

更新日期：2012-03-23 00:00:00

abstract：UNLABELLED:The effect of oryzanol (well known hypolipidemic component in rice bran oil) and its chemical constituents- ferulic acid (FA) and phytosterols on hypolipidemia were investigated. METHODS AND RESULTS:Docking (in silico) studies showed that FA had a better binding ability with lipase while sterols bound well ...

journal_title：Biochemical and biophysical research communications

authors： Bhaskaragoud G,Rajath S,Mahendra VP,Kumar GS,Gopala Krishna AG,Kumar GS

更新日期：2016-07-22 00:00:00

abstract：:Leber's hereditary optic neuropathy (LHON) has been associated with "primary" and "secondary" mtDNA missense point mutations, and a synergistic role has been proposed for secondary mutations. No previous study has investigated the effects of LHON primary or primary plus secondary mutations on the respiratory competenc...

journal_title：Biochemical and biophysical research communications

authors： Vergani L,Martinuzzi A,Carelli V,Cortelli P,Montagna P,Schievano G,Carrozzo R,Angelini C,Lugaresi E

更新日期：1995-05-25 00:00:00

abstract：:p47-phox is one of the cytosolic activation factors of NADPH oxidase in neutrophils and known to translocate to plasma membranes and function by protein kinase C-phosphorylation. In cytosol fraction, prepared from calyculin A-treated neutrophils, the activity of cytosolic factor to activate NADPH oxidase was more redu...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Saeki S,Yamane H,Okamura N,Ishibashi S

更新日期：1995-11-02 00:00:00

abstract：:Aggregation of proteins is a frequent occurrence during their transition from random coil to native structure. The influence of cyclodextrins in the refolding of carbonic anhydrase under aggregating conditions was studied. Cyclodextrin prevented formation of protein aggregates during renaturation of carbonic anhydrase...

journal_title：Biochemical and biophysical research communications

authors： Karuppiah N,Sharma A

更新日期：1995-06-06 00:00:00

abstract：:Rab5 is a GTP-binding protein that is crucial for endocytic machinery functions. We previously identified L-plastin as a binding protein for Rab5, using an affinity column with constitutively active Rab5. L- and T-plastin are isoforms of a plastin protein family belonging to actin-bundling proteins that are implicated...

journal_title：Biochemical and biophysical research communications

authors： Hagiwara M,Shinomiya H,Kashihara M,Kobayashi K,Tadokoro T,Yamamoto Y

更新日期：2011-04-15 00:00:00

abstract：:Synthesis of melanin starts from the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa) and then the oxidation of L-dopa yields dopaquinone by tyrosinase. Therefore, tyrosinase inhibitors have been established as important constituents of depigmentation agents. Recently, polyhydroxystilbene compounds, whi...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Tanaka T,Kido T,Baba K,Iinuma M,Matsumoto K,Akao Y,Nozawa Y

更新日期：2003-08-08 00:00:00

abstract：:In the areas of North Africa, Southeast Asia as well as South China, Nasopharyngeal carcinoma (NPC) is among the most widespread cancers. Plenty of research findings confirmed that Epstein-Barr virus (EBV) played a crucial role in NPC. EBV-encoded Latent membrane protein 2A (LMP2A) which continuously expressed in cell...

journal_title：Biochemical and biophysical research communications

authors： Cao Q,Zhang D,Mao Y,Meng C,Zhu J,Feng Z,Chen R

更新日期：2017-01-08 00:00:00

abstract：:CRACR2A protein is described in T cells as an EF-hand-containing modulator of calcium-release-activated calcium (CRAC) channels. Here we sought relevance to calcium entry of endothelial cells. Unexpectedly, short interfering RNA designed to deplete CRACR2A had no effect on CRAC channels in endothelial cells but reduce...

journal_title：Biochemical and biophysical research communications

authors： Wilson LA,McKeown L,Tumova S,Li J,Beech DJ

更新日期：2015-01-02 00:00:00

abstract：:Glutathione S-transferase P (GST-P) exists as a homodimeric form and has two tryptophan residues, Trp28 and Trp38, in each subunit. In order to elucidate the role of the two tryptophan residues in catalytic function, we examined intrinsic fluorescence of tryptophan residues and effect of chemical modification by N-bro...

journal_title：Biochemical and biophysical research communications

authors： Nishihira J,Ishibashi T,Sakai M,Nishi S,Kumazaki T

更新日期：1992-06-30 00:00:00

abstract：:The pregnant hog ovary is a rich source of a novel exopeptidase that catalyzes the release, at pH 5.0, of collagen-related (P3-P2-P1) "triplets" such as Gly-Pro-Met, Gly-Pro-Arg, and Gly-Pro-Ala from arylamide derivatives, provided the N termini are unsubstituted. Corresponding derivatives of related (P2-P1) dipeptide...

journal_title：Biochemical and biophysical research communications

authors： McDonald JK,Hoisington AR,Eisenhauer DA

更新日期：1985-01-16 00:00:00

abstract：:Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating e...

journal_title：Biochemical and biophysical research communications

authors： Lee SW,Moon SW,Park JS,Suh HR,Han HC

更新日期：2021-01-16 00:00:00

abstract：:Exposure of isolated rat dispersed pancreatic acini to increasing concentrations (10 to 1000 ng/ml) of purified exotoxin-A from Pseudomonas aeruginosa resulted in a progressive inhibition of 3H-leucine incorporation into "cellular" (those remaining in the cells) and "secretory" (those released into the medium) protein...

journal_title：Biochemical and biophysical research communications

authors： Geokas MC,Vesenka GD,Dubick MA,Majumdar AP

更新日期：1985-02-28 00:00:00

abstract：:An early signaling event during the adhesion and spreading of cells is integrin-mediated tyrosine phosphorylation of the cytoskeletal adaptor protein paxillin and the non-receptor tyrosine kinase pp125(FAK) at focal contacts. To determine the influence of surface-charge and -adsorbed adhesion proteins on this signalin...

journal_title：Biochemical and biophysical research communications

authors： Sommerfeldt DW,McLeod KJ,Rubin CT,Hadjiargyrou M

更新日期：2001-07-13 00:00:00

abstract：:Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running ...

journal_title：Biochemical and biophysical research communications

authors： Soya H,Nakamura T,Deocaris CC,Kimpara A,Iimura M,Fujikawa T,Chang H,McEwen BS,Nishijima T

更新日期：2007-07-13 00:00:00

abstract：:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

journal_title：Biochemical and biophysical research communications

authors： Margulis A,Pozdnyakov N,Sitaramayya A

更新日期：1996-01-05 00:00:00

abstract：:Amantadine and oseltamivir are used to treat influenza A virus infections; however, resistance to these drugs has been widely reported throughout the world. In this study, the frequency and genetic characteristics of the drug-resistant influenza A viruses that circulated in Thailand from 2006 to 2008 were investigated...

journal_title：Biochemical and biophysical research communications

authors： Bai GR,Chittaganpitch M,Kanai Y,Li YG,Auwanit W,Ikuta K,Sawanpanyalert P

更新日期：2009-12-18 00:00:00

abstract：:Receptor activator of NF-κB (RANK) and RANK ligand (RANKL) are known to play an important role in the development and progression of breast cancer. However, the mechanisms by which stimuli regulate the expression of RANK and RANKL in breast cancer cells are largely unknown. In this study, we show that hypoxia, a commo...

journal_title：Biochemical and biophysical research communications

authors： Tang ZN,Zhang F,Tang P,Qi XW,Jiang J

更新日期：2011-05-13 00:00:00

abstract：:Molecular motors move many intracellular cargos along microtubules. Recently, it has been hypothesized that in vivo cargo velocity can be used to determine the number of engaged motors. We use theoretical and experimental approaches to investigate these assertions, and find that this hypothesis is inconsistent with pr...

journal_title：Biochemical and biophysical research communications

authors： Martinez JE,Vershinin MD,Shubeita GT,Gross SP

更新日期：2007-02-16 00:00:00

abstract：:TGFbeta is of crucial importance during transdifferentiation of resting retinoid-storing hepatic stellate cells (HSC) to extracellular matrix producing myofibroblasts (MFB) and consequently, inhibition of TGFbeta signal transduction is an effective means for preventing experimental fibrosis. We have shown that isolate...

journal_title：Biochemical and biophysical research communications

authors： Dooley S,Streckert M,Delvoux B,Gressner AM

更新日期：2001-05-11 00:00:00

abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

journal_title：Biochemical and biophysical research communications

authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

更新日期：1994-12-15 00:00:00

abstract：:Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and ac...

journal_title：Biochemical and biophysical research communications

authors： Panfoli I,Morelli A,Pepe I

更新日期：1990-11-30 00:00:00

abstract：:A mitosis inhibiting peptide pyroGlu-Glu-Asp-Ser-GlyOH has been isolated from mouse skin extracts. Both the biological and a synthetic peptide with the same structure reversibly inhibit epidermal mitoses in a curvilinear fashion after intraperitoneal injection. The two compounds are chromatographically identical. ...

journal_title：Biochemical and biophysical research communications

authors： Reichelt KL,Elgjo K,Edminson PD

更新日期：1987-08-14 00:00:00

abstract：:Pseudohypoaldosteronism type II (PHAII), an autosomal dominant disorder characterized by hypertension, hyperkalemia, and hyperchloremic acidosis, is reportedly due to mutations in WNK1 and WNK4 kinase genes. However, the pathogenesis of the disease remains unknown. Mutations in the WNK1 gene are the deletions in the f...

journal_title：Biochemical and biophysical research communications

authors： Ohta A,Yang SS,Rai T,Chiga M,Sasaki S,Uchida S

更新日期：2006-10-20 00:00:00

abstract：:An 18-kDa lectin, with an N-terminal sequence displaying slight similarity to some lectins and fungal immunomodulatory proteins, was isolated from the mushroom Ganoderma capense (Lloyd) Teng. It exhibited more potent mitogenic activity than that of concanavalin A toward mouse splenocytes, and antiproliferative activit...

journal_title：Biochemical and biophysical research communications

authors： Ngai PH,Ng TB

更新日期：2004-02-20 00:00:00

abstract：:The relation of expression of the LF-B1 gene with the L-type pyruvate kinase (L-PK) mRNA level in rat liver and hepatoma cells was investigated. The L-PK mRNA level in rat liver changed after partial hepatectomy, during development and on intake of a high carbohydrate diet, while the level of LF-B1 mRNA remained uncha...

journal_title：Biochemical and biophysical research communications

authors： Imai E,Noguchi T,Takenaka M,Yamada K,Matsuda T,Monaci P,Nicosia A,Tanaka T

更新日期：1991-05-15 00:00:00

abstract：:Previous structural and mutational studies of bovine pancreatic deoxyribonuclease I (bpDNase I) have demonstrated that the active site His134 and His252 played critical roles in catalysis. In our present study, mutations of these two His residues to Gln, Ala or Gly reduced the DNase activity by a factor of four to fiv...

journal_title：Biochemical and biophysical research communications

authors： Chen WJ,Lai PJ,Lai YS,Huang PT,Lin CC,Liao TH

更新日期：2007-01-19 00:00:00

abstract：:A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to th...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Matsuo H

更新日期：1984-07-31 00:00:00

abstract：:The amount of oxidative stress in severely traumatized patients is usually based on various individual parameters such as total antioxidants and lipid peroxidation. Serial measurements of plasma oxidation-reduction potential (ORP) in severely traumatized patients as a simple mean of assessing overall oxidative stress ...

journal_title：Biochemical and biophysical research communications

authors： Rael LT,Bar-Or R,Aumann RM,Slone DS,Mains CW,Bar-Or D

更新日期：2007-09-21 00:00:00