Abstract:
:Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compared to other compounds containing an adenine ring with substitutions at known positions. The results support a structure for cADPR in which cyclization is to position 1 of the adenine ring, rather than to N6, as has been previously proposed.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Kim H,Jacobson EL,Jacobson MKdoi
10.1006/bbrc.1993.1941subject
Has Abstractpub_date
1993-08-16 00:00:00pages
1143-7issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(83)71941-8journal_volume
194pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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