B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.

abstract：:Marked increase in protein levels of Mn-superoxide dismutase (Mn-SOD) was found in TNF-resistant cell lines after treatment with Tumor Necrosis Factor (TNF). No such increase was observed in Cu,Zn-superoxide dismutase (Cu, Zn-SOD) protein in either TNF-resistant or sensitive cells. These results support the data that ...

journal_title：Biochemical and biophysical research communications

authors： Kawaguchi T,Takeyasu A,Matsunobu K,Uda T,Ishizawa M,Suzuki K,Nishiura T,Ishikawa M,Taniguchi N

更新日期：1990-09-28 00:00:00

abstract：:Tetraheme cytochrome c3 (13 kDa) and flavodoxin (16 kDa), are small electron transfer proteins that have been used to mimic, in vitro, part of the electron-transfer chain that operates between substract electron donors and respiratory electron acceptors partners in Desulfovibrio species (Palma, N., Moura, I., LeGall, ...

journal_title：Biochemical and biophysical research communications

authors： Correia C,Monzani E,Moura I,Lampreia J,Moura JJ

更新日期：1999-03-16 00:00:00

abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

journal_title：Biochemical and biophysical research communications

authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

更新日期：2011-10-28 00:00:00

abstract：:The classification of molecular subtypes of breast cancer improves the prognostic accuracy and therapeutic benefits in clinic. However, because of the complexity of breast cancer, more biomarkers and functional molecules need to be explored. Here, analyzing the data in a huge cohort of breast cancer patients, we found...

journal_title：Biochemical and biophysical research communications

authors： Hua W,Sa KD,Zhang X,Jia LT,Zhao J,Yang AG,Zhang R,Fan J,Bian K

更新日期：2015-08-07 00:00:00

abstract：:Transgenic mouse which produces human alpha-fetoprotein (AFP) ubiquitously was used to study carbohydrate structures of AFP produced by various tissues as well as that in the serum. A series of tissues from the transgenic mouse were cultured in vitro and the AFP produced was analyzed by affinity electrophoreses with 4...

journal_title：Biochemical and biophysical research communications

authors： Koyama Y,Sakai M,Kitagawa T,Taketa K,Nishi S

更新日期：1996-06-25 00:00:00

abstract：:2H-NMR spectroscopy has been used to study the distribution of 2H atoms in brain lactate, after intraperitoneal injection of 2H2O. Information on brain metabolism was obtained from the ratio [(3-2H) lactate]/[(2-2H)-lactate] which was found very sensitive to the PO2 in the breathing air. The dependence of this ratio o...

journal_title：Biochemical and biophysical research communications

authors： Vianello F,Scarpa M,Viglino P,Rigo A

更新日期：1997-08-28 00:00:00

abstract：:gamma-glutamyltranspeptidase (GGT) is a key enzyme implicated in the homeostasis of intracellular reduced glutathione (GSH) and hence in the regulation of the cellular redox state. Besides, the extracellular cleavage of GSH by GGT leads to reactive oxygen species (ROS) production, depending on the generation and enhan...

journal_title：Biochemical and biophysical research communications

authors： Accaoui MJ,Enoiu M,Mergny M,Masson C,Dominici S,Wellman M,Visvikis A

更新日期：2000-10-05 00:00:00

abstract：:A cDNA clone for human transferrin was identified from a human liver cDNA library by pre-screening with different ss-cDNA probes against length-fractionated liver mRNAs, positive hybridization-selection and nucleotide sequence analysis. The insert was of 1 kb, encoding human transferrin from aminoacid 403 through the ...

journal_title：Biochemical and biophysical research communications

authors： Uzan G,Frain M,Park I,Besmond C,Maessen G,Trépat JS,Zakin MM,Kahn A

更新日期：1984-02-29 00:00:00

abstract：:Ultrasound (US) has emerged as a promising noninvasive modality for neuromodulation. Despite previous evidence that US may mediate cellular response by activating mechanosensitive ion channels embedded in the cell membrane, the underlying mechanism is not well understood. In this work, we developed a vertically deploy...

journal_title：Biochemical and biophysical research communications

authors： Liao D,Li F,Lu D,Zhong P

更新日期：2019-10-20 00:00:00

abstract：INTRODUCTION:Radiotherapy is an equivalent alternative or complement to radical prostatectomy, with high therapeutic efficacy. High risk patients, however, experience high relapse rates, so that research on radio-sensitization is the most evident route to improve curability of this common disease. MATERIALS AND METHOD...

journal_title：Biochemical and biophysical research communications

authors： Koukourakis MI,Kalamida D,Mitrakas A,Pouliliou S,Kalamida S,Sivridis E,Giatromanolaki A

更新日期：2015-05-29 00:00:00

abstract：:Most vertebrates possess at least two gonadotropin-releasing hormone (GnRH) neuron types. To understand the physiological significance of the multiple GnRH systems in the brain, we examined three GnRH neuron type-specific transcriptomes using single-cell microarray analyses in the medaka (Oryzias latipes). A microarra...

journal_title：Biochemical and biophysical research communications

authors： Moriya S,Ogawa S,Parhar IS

更新日期：2013-06-14 00:00:00

abstract：:Rabbit brain synaptosomes bind the 1,4-dihydropyridine derivative (+)[3H]-PN 200-110 with an equilibrium dissociation constant of 0.04 nM and a maximal binding capacity of 400 fmol/mg of protein. Using polyclonal antibodies raised against the different components of the skeletal muscle 1,4-dihydropyridine receptor, we...

journal_title：Biochemical and biophysical research communications

authors： Schmid A,Barhanin J,Mourre C,Coppola T,Borsotto M,Lazdunski M

更新日期：1986-09-30 00:00:00

abstract：:The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min (APC(Min/+)) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups (N=10) of six-week-old female C57BL/6J APC(Min/+) and the co...

journal_title：Biochemical and biophysical research communications

authors： Williams JL,Kashfi K,Ouyang N,del Soldato P,Kopelovich L,Rigas B

更新日期：2004-01-16 00:00:00

abstract：:Regeneration and functional reconstruction of peripheral nerve defects remained a significant clinical challenge. Nerve guide conduits, with seed cells or neurotrophic factors (NTFs), had been widely used to improve the repair and regeneration of injured peripheral nerve. Pyrroloquinoline quinone (PQQ) was an antioxid...

journal_title：Biochemical and biophysical research communications

authors： Luo L,Gan L,Liu Y,Tian W,Tong Z,Wang X,Huselstein C,Chen Y

更新日期：2015-02-20 00:00:00

abstract：:Previously we demonstrated that the histamine H2 receptor can activate both the adenylate cyclase and phosphoinositide/protein kinase (PKC) signaling pathways. Although dual coupling occurs via separate GTP-dependent mechanisms the structural components of the H2 receptor directing differential signaling have not been...

journal_title：Biochemical and biophysical research communications

authors： Wang LD,Gantz I,Butler K,Hoeltzel M,Del Valle J

更新日期：2000-09-24 00:00:00

abstract：:Immunoglobulin A (IgA) nephropathy is an important cause of end-stage kidney disease (ESKD). Tubulointerstitial inflammation and subsequent fibrosis appear to be a major contributor of the disease progression to ESKD; however, the underlying mechanism is poorly understood. Herein, we report that a unique feature of CY...

journal_title：Biochemical and biophysical research communications

authors： Cui TG,Ichikawa T,Yang M,Dong X,Li J,Cui T

更新日期：2009-12-11 00:00:00

abstract：:The human pregnane X receptor (hPXR) plays a key role in the regulation of both drug metabolism and efflux by inducing the expression of CYP3A4 and MDR1 gene. Using reverse transcription-polymerase chain reaction (RT-PCR) analysis, we identified seven novel splicing variants of hPXR in tissue from a single human liver...

journal_title：Biochemical and biophysical research communications

authors： Fukuen S,Fukuda T,Matsuda H,Sumida A,Yamamoto I,Inaba T,Azuma J

更新日期：2002-11-01 00:00:00

abstract：:The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the growth of normal human keratinocytes cultured in serum-free medium was investigated. 1,25(OH)2D3 inhibited the cell growth at 10(-7) M by 75.3% and at 10(-6) M almost completely. The growth inhibition was accompanied by changes related to proliferation: (1) r...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Hashimoto K,Nishida Y,Hashiro M,Yoshikawa K

更新日期：1990-01-30 00:00:00

abstract：:Hypothetical lambda protein ORF314 shows significant homology with the carboxyl end of phage T4 tail-fiber protein gp37. Homology can also be demonstrated between hypothetical lambda protein ORF194 and a fragment of bacteriophage T4 protein gp38. This sequence homology is also reflected in the genomic sequences of the...

journal_title：Biochemical and biophysical research communications

authors： George DG,Yeh LS,Barker WC

更新日期：1983-09-30 00:00:00

abstract：:The family of endothelins, endothelin-1 (ET-1), ET-2 and ET-3, act on two subtypes of receptors called ETA and ETB receptors. BQ123 is an ETA-selective competitive antagonist. In this study, however, BQ123 inhibited ET-1-induced transients of cytosolic Ca2+ concentrations ([Ca2+]i) in an apparently noncompetitive mann...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto A,Yanagisawa M,Tsujimoto G,Nakao K,Toyo-oka T,Masaki T

更新日期：1994-04-29 00:00:00

abstract：:Bone mass is regulated by various molecules including endogenous factors as well as exogenous factors, such as nutrients and pollutants. Aryl hydrocarbon receptor (AhR) is known as a dioxin receptor and is responsible for various pathological and physiological processes. However, the role of AhR in bone homeostasis re...

journal_title：Biochemical and biophysical research communications

authors： Yu TY,Kondo T,Matsumoto T,Fujii-Kuriyama Y,Imai Y

更新日期：2014-07-18 00:00:00

abstract：:Chondromodulin-I (ChM-I) is a cartilage-specific glycoprotein that stimulates the growth of chondrocytes and inhibits the tube formation of endothelial cells. In the present study, we identified a novel ChM-I like molecule, designated ChM1L. Cloning of full length cDNAs of human, mouse, and rat ChM1L revealed that ChM...

journal_title：Biochemical and biophysical research communications

authors： Yamana K,Wada H,Takahashi Y,Sato H,Kasahara Y,Kiyoki M

更新日期：2001-02-02 00:00:00

abstract：:The effects of omeprazole on developing rat stomach mucosa were investigated. Infant rats were given subcutaneous injections of either omeprazole (25 mg/kg body weight/day) or vehicle once a day from the day after birth. As a result, omeprazole caused an elevation of mucosal pH and suppressed an increase in mucosal pe...

journal_title：Biochemical and biophysical research communications

authors： Kakei N,Ichinose M,Tsukada S,Tatematsu M,Tezuka N,Furihata C,Yahagi N,Matsushima M,Miki K,Kurokawa K

更新日期：1993-11-30 00:00:00

abstract：:We studied the effect of eotaxin, a novel eosinophil-active CC chemokine with high target cell specificity, on human basophils. Eotaxin induced higher levels of chemotactic response with a lower ED50 compared with RANTES in basophils; half-maximal migration occurred at a concentration of approximately 3 nM. On the oth...

journal_title：Biochemical and biophysical research communications

authors： Yamada H,Hirai K,Miyamasu M,Iikura M,Misaki Y,Shoji S,Takaishi T,Kasahara T,Morita Y,Ito K

更新日期：1997-02-13 00:00:00

abstract：:Two genomic clones containing the 3'-end of CYP3A7, the whole 5'-flanking region plus the first exon of CYP3A5 were isolated from two different human genomic banks and sequenced. The 5'-flanking region of CYP3A5, from nucleotide -1 to -1434, was 60% and 59% similar with the corresponding regions of CYP3A4 and CYP3A7, ...

journal_title：Biochemical and biophysical research communications

authors： Jounaïdi Y,Guzelian PS,Maurel P,Vilarem MJ

更新日期：1994-12-30 00:00:00

abstract：:Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes in breast cancer and other solid tumors, however the identity and roles of many of the soluble factors these macrophages produce remains to be elucidated in detail. In addition to producing angiogenic factors (e.g. VEGF), protea...

journal_title：Biochemical and biophysical research communications

authors： Levano KS,Jung EH,Kenny PA

更新日期：2011-07-22 00:00:00

abstract：:Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that c...

journal_title：Biochemical and biophysical research communications

authors： Zhou F,Shen Y,Liu B,Chen X,Wan L,Peng D

更新日期：2017-03-18 00:00:00

abstract：:A folded synthetic peptide analog of NDF (NDF5), which has the 52 amino acid EGF-like domain of NDF alpha 2, has been characterized. The folded peptide stimulates tyrosine phosphorylation of Her2, Her3 and Her4 in breast cancer cells and competes with low affinity with full-length NDF alpha 2 for binding to the cells,...

journal_title：Biochemical and biophysical research communications

authors： Kita Y,Mayer J,Zamborelli T,Hara S,Rohde M,Watson E,Koski R,Ratzkin B,Nicolson M

更新日期：1995-05-16 00:00:00

abstract：:Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cbeta4 (PLCbeta4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we inv...

journal_title：Biochemical and biophysical research communications

authors： Kameyama M,Yamaguchi I,Ichikawa K,Sugiyama T,Hirono M,Hori H,Ikeda M,Kuwahata Y,Eguchi N,Urade Y,Yoshioka T

更新日期：2003-04-25 00:00:00

abstract：:Mitochondrial reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. In particular, high levels of mitochondrial ROS in hypoxic cells regulate many angiogenesis-related diseases, including cancer and ischemic disorders. Here we report a...

journal_title：Biochemical and biophysical research communications

authors： Kim KH,Park JY,Jung HJ,Kwon HJ

更新日期：2011-01-07 00:00:00