当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Kinetic analyses of the effects of hyperoxia and hypoxia on vascular cyclooxygenase activity in vitro.

Kinetic analyses of the effects of hyperoxia and hypoxia on vascular cyclooxygenase activity in vitro.

Abstract：

:Kinetic analyses were performed to understand the mechanism of hyperoxic induced inhibition of prostacyclin synthesis by human umbilical arteries. Brief exposure of arterial segments to oxygen resulted in over 30% decrease in Vmax of cyclooxygenase in treated vessels. In contrast, cyclooxygenase from hypoxic arterial segments showed approximately a 49% increase in Vmax. There were no significant differences in apparent Km values. These studies suggest that the decreased production of prostacyclin by hyperoxic tissue is due to cyclooxygenase inactivation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamaja Setty BN,Walenga RW,Stuart MJ

doi

10.1016/s0006-291x(84)80350-2

subject

Has Abstract

pub_date

1984-11-30 00:00:00

pages

170-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)80350-2

journal_volume

125

pub_type

杂志文章

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