Abstract:
:GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase I is regulated on a transcriptional level by a variety of cytokines like interleukin 1beta or tumor necrosis factor alpha. The present paper reports that stimulation of protein kinase C by angiotensin II, platelet-derived growth factor BB or the phorbol ester 12-O-tetradecanoylphorbol-13-acetate triggers the phosphorylation and activation of GTP cyclohydrolase I. These data establish that in addition to transcriptional regulation, there is a prominent post-transcriptional modulation of enzyme activity.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Lapize C,Plüss C,Werner ER,Huwiler A,Pfeilschifter Jdoi
10.1006/bbrc.1998.9552subject
Has Abstractpub_date
1998-10-29 00:00:00pages
802-5issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(98)99552-3journal_volume
251pub_type
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