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Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro.

Abstract：

:Genomic imprinting is an epigenetic phenomenon by which a subset of genes is asymmetrically expressed in a parent-of-origin manner. However, little is known regarding the epigenetic behaviors of imprinted genes during human development. Here, we show dynamic epigenetic changes in imprinted genes in hESCs during in vitro differentiation into specialized cell types. Out of 9 imprinted genes with single nucleotide polymorphisms, mono-allelic expression for three imprinted genes (H19, KCNQ1OT1, and IPW), and bi- or partial-allelic expression for three imprinted genes (OSBPL5, PPP1R9A, and RTL1) were stably retained in H9-hESCs throughout differentiation, representing imprinting stability. Three imprinted genes (KCNK9, ATP10A, and SLC22A3) showed a loss and a gain of imprinting in a lineage-specific manner during differentiation. Changes in allelic expression of imprinted genes were observed in another hESC line during in vitro differentiation. These findings indicate that the allelic expression of imprinted genes may be vulnerable in a lineage-specific manner in human pluripotent stem cells during differentiation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Park SW,Kim J,Park JL,Ko JY,Im I,Do HS,Kim H,Tran NT,Lee SH,Kim YS,Cho YS,Lee DR,Han YM

doi

10.1016/j.bbrc.2014.02.141

subject

Has Abstract

pub_date

2014-04-04 00:00:00

pages

493-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)00426-4

journal_volume

446

pub_type

杂志文章

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